Ukusetshenziswa kwe-CMC embonini yezemithi

I-Carboxymethyl cellulose (CMC) ithola ukusetshenziswa okuningi embonini yezemithi ngenxa yezakhiwo zayo eziguquguqukayo. Nakhu okunye ukusetshenziswa okuvamile kwe-CMC kwezemithi:

1. I-Tablet Binder: I-CMC isetshenziswa kakhulu njengesihlanganisi ekwakhiweni kwethebhulethi ukuze kunikezwe amandla ahlangene nokuqinisekisa ubuqotho bethebhulethi. Isiza ukubamba izithako zemithi esebenzayo (ama-API) kanye nezinto ezisizayo ndawonye ngesikhathi sokuminyanisa, ukuvimbela ukuphuka kwethebhulethi noma ukuwohloka. I-CMC iphinde ikhuthaze ukukhululwa kwezidakamizwa ezifanayo kanye nokuqedwa.
2. I-Disintegrant: Ngokungeziwe ezintweni zayo ezibophayo, i-CMC ingasebenza njenge-disintegrant ekwakhiweni kwethebhulethi. Isiza ukuhlukana ngokushesha kwamaphilisi abe yizinhlayiyana ezincane lapho echayeke kumswakama, amathe, noma uketshezi lwamathumbu, okuvumela ukukhululwa kwezidakamizwa ngokushesha nangempumelelo nokumuncwa emzimbeni.
3. I-Film Coating Agent: I-CMC isetshenziswa njenge-ejenti yokuhlanganisa ifilimu ukuze inikeze ukunamathela okubushelelezi, okufanayo kumaphilisi namaphilisi. Ukumbozwa kusiza ukuvikela umuthi emswakama, ekukhanyeni, nasemoyeni, kumaski ukunambitheka okungajabulisi noma iphunga, futhi kuthuthukisa ukugwinya. Izembatho ezisuselwe ku-CMC zingaphinda zilawule amaphrofayili okukhishwa kwezidakamizwa, zithuthukise ukuzinza, futhi zenze kube lula ukuhlonza (isb, ngama-colorants).
4. I-Viscosity Modifier: I-CMC isetshenziswa njengesilungisi se-viscosity ekwakhiweni koketshezi okufana nokumiswa, ama-emulsion, ama-syrups, namaconsi iso. Yandisa i-viscosity yokubunjwa, ithuthukise ukuzinza kwayo, ukuphatha kalula, nokunamathela ezindaweni ezingaphansi kwe-mucosal. I-CMC isiza ukumisa izinhlayiya ezingancibiliki, ivimbele ukuzinza, futhi ithuthukise ukufana komkhiqizo.
5. Izixazululo ze-Ophthalmic: I-CMC ijwayele ukusetshenziswa ekwakhiweni kwamehlo, okuhlanganisa amaconsi esweni namajeli okugcoba, ngenxa yezakhiwo zayo ezinhle kakhulu zokunamathisela i-mucoadhesive kanye ne-lubricating. Isiza ukuthambisa futhi ivikele indawo ye-ocular, ithuthukise ukuqina kwefilimu yezinyembezi, futhi inciphise izimpawu ze-eye syndrome eyomile. Amaconsi esweni asuselwa ku-CMC angaphinda andise isikhathi sokuthintana nezidakamizwa futhi athuthukise ukutholakala kwe-ocular bioavailability.
6. Amalungiselelo Asesihloko: I-CMC ihlanganiswe ekwakhiweni kwezihloko okuhlukahlukene okufana nokhilimu, izinto zokuthambisa, amajeli, namafutha okugcoba njenge-ejenti ejiyayo, i-emulsifier, i-stabilizer, noma isithuthukisi se-viscosity. Ithuthukisa ukusakazeka komkhiqizo, ukugcwala kwesikhumba, nokuzinza kokwakheka. Amalungiselelo asekelwe ku-CMC asetshenziselwa ukuvikela isikhumba, ukugeleza kwamanzi, nokwelashwa kwezimo ze-dermatological.
7. Ukugqoka Amanxeba: I-CMC isetshenziswa emikhiqizweni yokunakekela amanxeba efana nokugqokwa kwe-hydrogel namajeli amanxeba ngenxa yezakhiwo zayo ezigcina umswakama nezikhuthaza ukuphulukiswa. Kuyasiza ukudala indawo yenxeba enomswakama evumela ukuvuselelwa kwezicubu, kukhuthaze ukuchithwa kwe-autolytic, futhi kusheshise ukuphulukiswa kwesilonda. Ukugqoka okusekelwe ku-CMC kunikeza umgoqo ovikelayo, ukumunca i-exudate, futhi kunciphise ubuhlungu.
8. I-Excipient in Formulations: I-CMC isebenza njengomsizi oguquguqukayo ekwenziweni kwemithi okuhlukahlukene, okuhlanganisa amafomu emithamo eqinile yomlomo (amaphilisi, amaphilisi), amafomu omthamo owuketshezi (ukumiswa, izixazululo), amafomu omthamo we-semisolid (amafutha, okhilimu), kanye nemikhiqizo ekhethekile (imigomo, izinhlelo zokulethwa kwezakhi zofuzo). Ithuthukisa ukusebenza kokwakheka, ukuzinza, nokwamukeleka kwesiguli.

I-CMC idlala indima ebalulekile embonini yemithi ngokwenza ngcono ikhwalithi, ukusebenza kahle, kanye nolwazi lwesiguli lwezinhlobonhlobo zemikhiqizo yezidakamizwa kanye nokwakheka. Ukuphepha kwayo, i-biocompatibility, kanye nokwamukelwa okulawulwayo kuyenza ibe inketho ekhethwayo kubakhiqizi bemithi emhlabeni wonke.