IHydroxypropyl methylcellulose (HPMC) iyi-polymer yokwenziwa yokwenziwa esetshenziswa kabanzi ezimbonini eziningi, ikakhulukazi emkhakheni wezokwelapha. I-HPMC isiphenduke i-excipient ebaluleke kakhulu emalungiselelweni emithi ngenxa ye-biocompatibility yayo, ukungabi nobuthi kanye nezakhiwo ezinhle kakhulu zomzimba namakhemikhali.
(1) Izici eziyisisekelo zebanga lezemithi i-HPMC
I-HPMC i-non-ionic cellulose ether elungiselelwe ukusabela kwe-cellulose nge-propylene oxide ne-methyl chloride ngaphansi kwezimo ze-alkali. Isakhiwo sayo samakhemikhali esiyingqayizivele sinikeza i-HPMC ukuncibilika okuhle kakhulu, ukujiya, ukwakheka kwefilimu kanye nezakhiwo ze-emulsifying. Okulandelayo ezinye izici ezibalulekile ze-HPMC:
Ukunyibilika kwamanzi nokuncika kwe-pH: I-HPMC incibilika emanzini abandayo futhi yakhe isixazululo se-viscous esisobala. I-viscosity yesisombululo sayo ihlobene nokugxila kanye nesisindo samangqamuzana, futhi inokuqina okuqinile ku-pH futhi ingahlala izinzile kuzo zombili izindawo ezine-acidic ne-alkaline.
Izakhiwo ze-Thermogel: I-HPMC ibonisa izakhiwo ze-thermogel eziyingqayizivele lapho ishiswa. Ingenza ijeli uma ishiselwa ezingeni elithile lokushisa futhi ibuyele esimweni soketshezi ngemva kokupholisa. Lesi sakhiwo sibaluleke kakhulu emalungiselelweni okukhishwa kwezidakamizwa okuqhubekayo.
I-Biocompatibility kanye ne-non-toxicity: Njengoba i-HPMC iphuma ku-cellulose futhi ayinakho ukushaja futhi ngeke isabele kwezinye izithako, inokuvumelana okuhle kakhulu kwe-biocompatibility futhi ngeke imuncwe emzimbeni. Kuyi-excipient engenabuthi.
(2) Ukusetshenziswa kwe-HPMC emithini
I-HPMC isetshenziswa kakhulu embonini yezemithi, ihlanganisa imikhakha eminingi efana nemithi yomlomo, yezihloko kanye nemijovo. Izikhombisi-ndlela eziyinhloko zohlelo lokusebenza yilezi:
1. Izinto zokwakha ifilimu ezibhebheni
I-HPMC isetshenziswa kabanzi enqubweni yokumboza amaphilisi njengento yokwenza ifilimu. Ukugqoka kwethebhulethi akukwazi nje ukuvikela izidakamizwa ethonyeni lemvelo yangaphandle, njengomswakama nokukhanya, kodwa futhi kufihla iphunga elibi kanye nokunambitheka kwezidakamizwa, ngaleyo ndlela kuthuthukise ukuhambisana nesiguli. Ifilimu eyakhiwe yi-HPMC inokumelana okuhle kwamanzi namandla, okunganweba ngempumelelo impilo yeshalofu yezidakamizwa.
Ngesikhathi esifanayo, i-HPMC ingasetshenziswa futhi njengengxenye eyinhloko yolwelwesi olulawulwayo olukhishwayo ukuze kukhiqizwe amaphilisi akhipha okuzinzile kanye nokukhishwa okulawulwayo. Izakhiwo zayo zejeli ezishisayo zivumela izidakamizwa ukuba zikhishwe emzimbeni ngesilinganiso sokukhululwa esinqunyiwe, ngaleyo ndlela kuzuzwe umphumela wokwelashwa kwezidakamizwa okuthatha isikhathi eside. Lokhu kubaluleke kakhulu ekwelapheni izifo ezingamahlalakhona, njengezidingo zemithi yesikhathi eside zeziguli ezinesifo sikashukela kanye nomfutho wegazi ophakeme.
2. Njengomenzeli wokukhishwa okuqhubekayo
I-HPMC isetshenziswa kabanzi njenge-ejenti ekhishwa njalo emalungiselelweni emithi yomlomo. Ngenxa yokuthi ingenza ijeli emanzini futhi ungqimba lwejeli luncibilike kancane kancane njengoba umuthi ukhishwa, ungalawula ngempumelelo izinga lokukhululwa komuthi. Lolu hlelo lokusebenza lubaluleke kakhulu emithini edinga ukukhishwa kwezidakamizwa ezithatha isikhathi eside, njenge-insulin, ama-antidepressants, njll.
Endaweni yamathumbu, ungqimba lwejeli lwe-HPMC lungalawula izinga lokukhululwa komuthi, lugweme ukukhululwa ngokushesha komuthi ngesikhathi esifushane, ngaleyo ndlela kuncishiswe imiphumela emibi futhi kwandise ukusebenza kahle. Le ndawo ekhishwa isikhathi eside ifaneleka ikakhulukazi ukwelashwa kwezidakamizwa ezidinga ukugxiliswa kwezidakamizwa zegazi okuzinzile, njengama-antibiotics, izidakamizwa ezilwa nesithuthwane, njll.
3. Njengomuntu ohlanganisayo
I-HPMC ivamise ukusetshenziswa njengesihlanganisi kunqubo yokukhiqiza ithebhulethi. Ngokungeza i-HPMC ezinhlayiyeni zezidakamizwa noma izimpushana, uketshezi nokunamathela kwayo kungathuthukiswa, ngaleyo ndlela kuthuthukiswe umphumela wokucindezela namandla ethebhulethi. Ukungabi nobuthi kanye nokuzinza kwe-HPMC kuyenza ibe isibopho esifanelekile kumathebulethi, ama-granules namaphilisi.
4. Njenge-thickener kanye ne-stabilizer
Emalungiselelweni e-liquid, i-HPMC isetshenziswa kabanzi njenge-thickener kanye ne-stabilizer oketshezini oluhlukahlukene lomlomo, amaconsi esweni nama-creams asezindaweni. Ukuqina kwayo kungakhuphula i-viscosity yezidakamizwa eziwuketshezi, kugweme ukuhlukaniswa kwezidakamizwa noma imvula, futhi kuqinisekise ukusatshalaliswa okufanayo kwezithako zezidakamizwa. Ngasikhathi sinye, i-lubricity kanye nezakhiwo zokuthambisa ze-HPMC ziyenza ikwazi ukwehlisa ngempumelelo ukungaphatheki kahle kwamehlo kumathonsi iso futhi ivikele amehlo ekucasukeni kwangaphandle.
5. Isetshenziswa kuma-capsules
Njenge-cellulose esuselwe esitshalweni, i-HPMC inokuvumelana okuhle kwe-biocompatibility, okuyenza ibe into ebalulekile ekwenzeni amaphilisi ezitshalo. Uma kuqhathaniswa namaphilisi e-gelatin esilwane esivamile, amaphilisi e-HPMC anozinzo olungcono, ikakhulukazi ezindaweni ezishisayo nezinomswakama ophezulu, futhi akulula ukuwohloka noma ukuncibilika. Ngaphezu kwalokho, amaphilisi e-HPMC afanele abantu abadla imifino kanye neziguli ezingazwani ne-gelatin, akhulisa ububanzi bokusetshenziswa kwezidakamizwa ze-capsule.
(3) Okunye ukusetshenziswa kwezidakamizwa kwe-HPMC
Ngaphezu kwezicelo ezijwayelekile zezidakamizwa ezingenhla, i-HPMC ingasetshenziswa futhi kwezinye izinkambu zezidakamizwa ezithile. Isibonelo, ngemva kokuhlinzwa kwe-ophthalmic, i-HPMC isetshenziswa kumaconsi esweni njengesithambiso sokunciphisa ukungqubuzana ebusweni beso futhi kukhuthaze ukululama. Ngaphezu kwalokho, i-HPMC ingasetshenziswa futhi kuma-oints namajeli ukukhuthaza ukumuncwa kwezidakamizwa kanye nokwenza ngcono ukusebenza kahle kwezidakamizwa zendawo.
I-HPMC yebanga lezemithi idlala indima ebalulekile ekulungiseleleni izidakamizwa ngenxa yezakhiwo zayo ezinhle kakhulu zomzimba namakhemikhali. Njengomsizi wemithi esebenzayo, i-HPMC ayikwazi nje ukuthuthukisa ukuzinza kwezidakamizwa nokulawula ukukhishwa kwezidakamizwa, kodwa futhi ithuthukise isipiliyoni sokuthatha umuthi futhi yandise ukuthobela kwesiguli. Ngokuthuthuka okuqhubekayo kobuchwepheshe bezemithi, inkambu yokusetshenziswa kwe-HPMC izoba banzi futhi idlale indima ebaluleke kakhulu ekuthuthukisweni kwezidakamizwa esikhathini esizayo.
Isikhathi sokuthumela: Sep-19-2024