I-Hydroxypropyl methylcellulose, evame ukwaziwa nge-HPMC, iyisithako semithi esetshenziswa kakhulu kanye nesithasiselo sokudla. Ngenxa yokuncibilika kwayo okuhle kakhulu, ikhono lokubopha kanye nezakhiwo zefilimu, isetshenziswe kabanzi embonini yezemithi. I-HPMC ijwayele ukusetshenziswa embonini yokudla njenge-thickener, emulsifier kanye nesiqinisi. Ukuhlanzeka kwe-HPMC kubaluleke kakhulu embonini yezemithi nokudla njengoba kuthinta ukusebenza kahle nokuphepha komkhiqizo. Lesi sihloko sizoxoxa ngokunqunywa kokuhlanzeka kwe-HPMC nezindlela zayo.
Ayini ama-HPMC?
IHydroxypropylmethylcellulose (HPMC) i-ether cellulose etholakala ku-methylcellulose. Isisindo sayo samangqamuzana singama-Dalton angu-10,000 kuya kwangu-1,000,000, futhi iyimpushana emhlophe noma emhlophe, engenaphunga futhi ayinambitheki. I-HPMC incibilika kalula emanzini, futhi incibilika kwezinye izinyibilikisi eziphilayo njenge-ethanol, i-butanol, ne-chloroform. Inezici ezithile eziyingqayizivele njengokugcina amanzi, ukujiya kanye nekhono lokubopha, okuyenza ibe ilungele izimboni zemithi nokudla.
Ukunqunywa kokuhlanzeka kwe-HPMC
Ukuhlanzeka kwe-HPMC kuncike ezintweni ezimbalwa ezifana ne-degree of substitution (DS), umswakama kanye nokuqukethwe komlotha. I-DS imele inani lamaqembu e-hydroxyl esikhundleni samaqembu e-hydroxypropyl ku-molecule ye-cellulose. Izinga eliphezulu lokushintsha likhuphula ukunyibilika kwe-HPMC futhi lithuthukisa ikhono lokwenza ifilimu. Ngokuphambene, izinga eliphansi lokushintsha kuzoholela ekuncipheni kokuncibilika kanye nezakhiwo ezimbi zokwakha ifilimu.
HPMC Purity Determination Indlela
Kunezindlela ezimbalwa zokunquma ukuhlanzeka kwe-HPMC, okuhlanganisa i-acid-base titration, ukuhlaziywa kwe-elemental, i-high-performance liquid chromatography (HPLC), kanye ne-infrared spectroscopy (IR). Nansi imininingwane yendlela ngayinye:
i-acid-base titration
Indlela isuselwe ekuphenduleni kokungathathi hlangothi phakathi kwamaqembu ane-acidic nayisisekelo ku-HPMC. Okokuqala, i-HPMC incibilika ku-solvent futhi umthamo owaziwayo we-asidi noma isixazululo sesisekelo sokuhlushwa okwaziwayo uyengezwa. I-Titration yenziwa kuze kube yilapho i-pH ifinyelela endaweni engathathi hlangothi. Kusukela enanini le-asidi noma isisekelo esisetshenzisiwe, izinga lokushintsha lingabalwa.
Ukuhlaziya okuyisisekelo
Ukuhlaziywa kwe-elemental kulinganisa iphesenti lento ngayinye ekhona kusampula, okuhlanganisa ikhabhoni, i-hydrogen, nomoya-mpilo. Izinga lokushintsha lingabalwa ukusuka enanini le-elementi ngayinye ekhona kusampula ye-HPMC.
I-High Performance Liquid Chromatography (HPLC)
I-HPLC iyindlela yokuhlaziya esetshenziswa kabanzi ehlukanisa izingxenye zengxube ngokusekelwe ekusebenzelaneni kwazo nezigaba ezimile neselula. Ku-HPMC, izinga lokushintsha lingabalwa ngokulinganisa isilinganiso se-hydroxypropyl kumaqembu e-methyl kusampula.
I-Infrared Spectroscopy (IR)
I-infrared spectroscopy iyindlela yokuhlaziya ekala ukumuncwa noma ukudluliswa kwemisebe ye-infrared ngesampula. I-HPMC ineziqongo ezihlukene zokumunca ze-hydroxyl, i-methyl ne-hydroxypropyl, engasetshenziswa ukunquma izinga lokushintshwa.
Ukuhlanzeka kwe-HPMC kubalulekile ezimbonini zemithi nezokudla, futhi ukuzimisela kwayo kubalulekile ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo komkhiqizo wokugcina. Izindlela ezimbalwa ezitholakalayo zokunquma ubumsulwa be-HPMC, okuhlanganisa i-acid-base titration, ukuhlaziya okuyisisekelo, i-HPLC, ne-IR. Indlela ngayinye inezinzuzo zayo kanye nokubi futhi ingakhethwa ngokuvumelana nezidingo ezithile zohlelo lokusebenza. Ukugcina ubumsulwa be-HPMC, kufanele igcinwe endaweni eyomile, epholile kude nokukhanya kwelanga nokunye ukungcola.
Isikhathi sokuthumela: Aug-25-2023