IHydroxylopyolin (HPMC) iyi-polymer esetshenziswa kakhulu embonini yezemithi futhi iyifomula ebalulekile. Isetshenziswa kakhulu njenge-adhesive esikalini esiqinile (njengamaphilisi, amaphilisi, nezinhlayiya), i-viscosity ethuthukisiwe i-ejenti kanye nokubola.
Ekulungiseleleni izidakamizwa, ukuqedwa kwezithako ezisebenzayo kubalulekile ukumunca nokukhiqiza umphumela wokwelapha. Nokho, ukuhlakazwa kwezithako ezisebenzayo kungase kuvinjwe ifomula. Ngakho-ke, kubalulekile ukuqonda ukuziphatha kokuqedwa kwe-HPMC kufomula yomuthi ngoba kuthinta ukusebenza kohlobo lomthamo.
Indlela yokuqedwa ye-HPMC
I-US Pharmacy (USP) ilinganise indlela yokuhlola yokuhlakaza i-HPMC. Le ndlela ngokuvamile ihilela ukusetshenziswa kwezinto ezincibilikayo, ezilingisa futhi zikala ukuncibilika kohlobo lomthamo phakathi nendawo yesixazululo. Ukuhlola kuhilela ukubeka umthamo kubhasikidi noma i-paddle, futhi ubhasikidi noma i-paddle izungeza esitsheni esiqukethe into encibilikisiwe.
I-solubility medium kufanele ikhethwe ngokuvumelana nokusetshenziswa okulindelekile komthamo (njengokuncibilika kwesisu noma kwamathumbu). Indlela evamile yokuncibilika kwe-HPMC ihlanganisa amanzi, isixazululo sebhafa se-phosphate kanye nejusi yesisu yokulingisa (SGF) noma uketshezi lwamathumbu e-analog (SIF).
Ukuze uqinisekise ukuphindaphinda nokunemba, imingcele yokuhlola kufanele ifane, njengejubane lokuzungezisa, izinga lokushisa, kanye nokuncibilika kwevolumu emaphakathi nesikhathi sokusampula. Bese usebenzisa indlela yokuhlaziya efanele ukuze uhlaziye isisombululo sesampula esitholwe ngezikhathi ezihlukene ukuze unqume inani lokuqedwa kwe-HPMC.
Izinyathelo zokuvimbela Lapho wenza ukuhlolwa kokuqedwa kwe-HPMC
1. Ukukhethwa kwendawo efanele yokuncibilika: Ukukhethwa kwendawo yokuncibilikisa kusekelwe ekusetshenzisweni okulindelekile kwefomu lomthamo. Ukukhetha indawo efanelekile yokuhlakaza kubaluleke kakhulu ngoba kuzothinta ukuziphatha kokuqedwa kwe-HPMC.
2. Ukuqinisekisa ngendlela efanele indlela yokuncibilika: Ukuqinisekisa indlela yokuncibilika ukuze kuqinisekiswe ukuthi ifanelekile futhi kubalulekile ukuhlangabezana nezidingo ze-ejensi elawulayo. Ukuqinisekisa kufanele kufake ukuqina nokuphindaphinda kwesilinganiso.
3. Ukumiswa kwamapharamitha wokuhlola: Imingcele yokuhlola, njengesivinini sokuzungezisa, izinga lokushisa, kanye nevolumu emaphakathi encibilikisiwe ithinta umphumela wokuhlolwa kokuqedwa. Ngakho-ke, le mingcele kufanele ifane ukuze kuqinisekiswe ukuvela kabusha nokuhlaziya okunembile.
4. Isampula: Ukusampula okucophelela kubalulekile ukuze uthole amasampula amele asuka ku-dissolving medium. Naka isikhathi namaphoyinti okusampula ukuze uqinisekise ukuthi isampula iqoqwa ngesikhathi esihlanganisiwe.
5. Indlela yokuhlaziya: Khetha indlela yokuhlaziya yokuhlaziya izoqinisekiswa, futhi kufanele ibe nokuzwela okufanele, ukukhetha nokunemba.
Ngamafuphi, ukuhlolwa kokuqedwa kwe-HPMC kuyithuluzi elibalulekile ekuthuthukisweni kwezidakamizwa kanye nefomula yezidakamizwa. Ilabhorethri yokulawula ikhwalithi iqhutshwa njalo ukuze kuqinisekiswe ukukhululwa okufanele kwezithako ezisebenzayo, futhi umuthi uphephile futhi usebenza ngempumelelo. Iphutha endleleni yokuhlola efanele lingase liholele ekungaqondini nasezitatimendeni ezingamanga ngokusebenza kwezidakamizwa. Ngakho-ke, kubalulekile ukulandela izindinganiso kanye nezinyathelo zokuvimbela ngesikhathi sokuhlolwa kokuqedwa.
Isikhathi sokuthumela: Jun-29-2023