I-Hydroxypropyl Methylcellulose (HPMC) iyinhlangano esetshenziswa kakhulu yeselula enezicelo ezahlukahlukene, njengomuthi, ukudla, izinto zokwakha nezimonyo. I-HPMC iyi-nonic, i-semi-zokwenziwa, i-inert polymer ene-solubity enhle yamanzi, ukuqina, ukunamathela kanye nezakhiwo ezenziwe ngefilimu.
Ukwakheka kanye nezakhiwo ze-HPMC
I-HPMC iyi-celtulose eguquliwe ekhiqizwa ukuphendula i-cellulose nge-methyl chloride ne-propelene oxide. Isakhiwo saso samangqamuzana siqukethe ukufaka esikhundleni kwe-methyl kanye ne-hpdroxypropyl, enikeza i-HPMC ehlukile ngokomzimba nangamakhemikhali, njenge-solubility enhle kakhulu, ukuvikela ama-colloid kanye nezakhiwo ezenziwe ngefilimu. I-HPMC ingahlukaniswa ibe ukucaciswa okuningi ngokuya ngokufakaza okuhlukile, futhi ukucaciswa ngakunye kune-solubity ehlukile futhi kusetshenziswa emanzini.
I-Solubity ye-HPMC emanzini
Ukuchithwa Kwendlela
I-HPMC ixhumana nama-molecule amanzi ngama-hydrogen bond ukwakha isixazululo. Inqubo yakhe yokuchithwa ifaka kancane kancane ama-molecule angena phakathi kwamaketanga ama-hpmc, acekele phansi ukuhlangana kwawo, ukuze amaketanga e-polymer anciphise amanzi ukuze akhe ikhambi elifanayo. I-solubity ye-HPMC ihlobene kakhulu nesisindo sayo se-molecular, uhlobo olubekiwe kanye nezinga lokufaka esikhundleni (DS). Ngokuvamile, ukukhuphuka kwesilinganiso sokufaka esikhundleni sakwa-substituent, okuphezulu kwe-solubity ye-HPMC emanzini.
Umphumela wokushisa kwe-solubity
Ukushisa kungenye yezinto ezibalulekile ezithinta i-solubity ye-HPMC. I-solubity ye-HPMC emanzini ikhombisa izici ezihlukile njengoba izinguquko zokushisa:
Ukuncishiswa kwezinga lokushisa Ukuze uthole i-HPMC ephansi, izinga lokushisa lamanzi elingamamitha angama-60 livame ukufudumala okulungile. Ukuze uthole i-HPMC ephezulu, uhla lokushisa oluphelele lokuqothula kungenzeka lube phezulu njengo-80 ° C.
I-gelation ngesikhathi sokupholisa: Lapho isixazululo se-HPMC sifudunyezwa emazingeni okushisa athile (imvamisa ka-60-80 ° C) ngesikhathi sokuchithwa bese kuphola kancane kancane, kuzokwakheka kancane kancane, ijeli eshisayo. Le gel ye-thermal iba izinzile ngemuva kokupholisa emazingeni okushisa egumbi futhi ingahle iphindiswe emanzini abandayo. Lesi simo sibaluleke kakhulu sokulungiswa kwezixazululo ze-HPMC ngezinhloso ezithile ezithile (ezinjengezidakamizwa ezigciniwe kwezidakamizwa).
Ukusebenza kahle: Ngokuvamile, amazinga okushisa aphezulu angasheshisa inqubo ye-HPMC. Kodwa-ke, izinga lokushisa kakhulu lingahle liholele ekunciphiseni kwe-polymer noma ukwehla kokuchithwa kokuqothula. Ngakho-ke, ekusebenzeni kwangempela, izinga lokushisa elifanelekile kufanele likhethwe njengoba kudingeka ukugwema ukonakaliswa okungadingekile kanye nezinguquko zempahla.
Umphumela we-PH ku-Solubity
Njenge-polymer engeyona eye-ionic, i-solubility ye-HPMC emanzini ayithinteka ngqo yinani le-PH Inani lesisombululo. Kodwa-ke, izimo ze-PH ezedlulele (njengezindawo ezinamandla ze-acidic noma ze-alkali) zingathinta izici zokuchithwa kwe-HPMC:
Izimo ze-Acidic: ngaphansi kwezimo eziqinile ze-acidic (ph <3), ezinye izibopho zamakhemikhali ze-HPMC (ezinjengezibopho ze-ether Kodwa-ke, ku-General Lise Acid Range (PH 3-6), i-HPMC isengachithwa kahle. Izimo ze-Alkalaline: Ngaphansi kwezimo eziqinile ze-alkali (PH> 11), i-HPMC ingahlehlisa, okuvame ukubangelwa ukusabela kwe-hydrolysprowpropyly. Ngaphansi kwezimo ezibuthakathaka ze-alkali (ph 7-9), i-solubity ye-HPMC imvamisa ayithintekanga kakhulu.
Indlela yokuchithwa kwe-HPMC
Ukuze uncibilike ngempumelelo i-HPMC, izindlela ezilandelayo zivame ukusetshenziswa:
Indlela yokuhlakazwa kwamanzi ebandayo: kancane engeza i-HPMC powder emanzini abandayo ngenkathi ivusa ukusakaza ngokulinganayo. Le ndlela ingavimba i-HPMC ukuthi isuka ngqo e-agglomerang emanzini, futhi ikhambi lakha isendlalelo esivikelayo. Ngemuva kwalokho, kancane kancane uyishiyela ku-60-80 ° C ukuze uyichithe ngokuphelele. Le ndlela ilungele ukuchithwa kwe-HPMC eningi.
Indlela eshisayo yokuhlakazeka kwamanzi: engeza i-HPMC emanzini ashisayo bese uyivuselela ngokushesha ukuyikhipha ngokushesha ekushiseni okuphezulu. Le ndlela ilungele i-HPMC ye-HPMC ephezulu, kepha ukunakwa kufanele kukhokhwe ukulawula amazinga okushisa ukuze igweme ukonakaliswa.
Indlela Yokulungiselela Ukulungiselela Ukulungiselela: Okokuqala, i-HPMC ichithwe ku-solvent ye-organic (njenge-ethanol), bese kancane kancane amanzi angezwa kancane kancane ukuze uyiguqulele ikhambi elinamanzi. Le ndlela ilungele izimo zesicelo ezikhethekile ezinezidingo eziphakeme ze-solubity.
Ukuchithwa Kwezicelo Zezicelo Ezisebenzayo
Kuzinhlelo zokusebenza ezisebenzayo, inqubo yokuqothula ye-HPMC idinga ukulungisiselwa ngokuya ngokusetshenziswa okuthile. Isibonelo, enkundleni yezemithi, kuvame ukudingekile ukwakha ikhambi elifanayo nelonakwawo angqubuzana futhi elizinzile, futhi ukulawulwa okuqinile kokushisa kanti i-PH kuyadingeka ukuze kuqinisekiswe ukuhlakanipha kanye nomsebenzi wezinto eziphilayo zesisombululo. Ezintweni zokwakha, i-solubity ye-HPMC ithinta izakhiwo ezenziwe ngefilimu namandla acindezelayo, ngakho-ke indlela enhle yokuqothula idinga ikhethwe ngokuhlanganiswa nezimo ezithile zemvelo.
I-solubity ye-HPMC emanzini ithinteka yizici eziningi, ikakhulukazi izinga lokushisa kanye no-pH. Ngokuvamile ukukhuluma, i-HPMC inciphisa ngokushesha emazingeni okushisa aphezulu (60-80 ° C), kepha angahlehlisa noma ancibilike ngaphansi kwezimo ze-PH ezedlulele. Ngakho-ke, kuzinhlelo zokusebenza ezisebenzayo, kuyadingeka ukuthi ukhethe izinga lokushisa elifanele kanye nobubanzi be-PH ngokuya ngokusetshenziswa okuqondile kanye nezimo zezemvelo ze-HPMC ukuqinisekisa i-solubity yayo enhle nokusebenza.
Isikhathi sePosi: Jun-25-2024