IHydroxypropyl Methylcellulose (HPMC) isiphenduke isithako esivame ukusetshenziswa ezihlalweni zokuhlanza izingubo ngenxa yokuqina kwayo okuhamba phambili, ukugcinwa kwamanzi kanye nezakhiwo ezimangazayo. I-HPMC ingukususelwa kokwenziwa kwe-cellulose, i-polymer yemvelo etholakala ezitshalweni. I-HPMC iyi-polymer engenamanzi enezinhlelo zokusebenza ezahlukahlukene embonini nasekukhiqizweni. Ezihlanzelweni zokuhlanza izingubo, i-HPMC isetshenziselwa ukuthuthukisa ukusebenza kokuhlanza okuphelele komkhiqizo.
I-HPMC iyinto ethokozisayo kakhulu. I-solubity ye-HPMC incike ezicini eziningana, kufaka phakathi isisindo sayo samangqamuzana, izinga lokufaka esikhundleni, kanye nokushisa. Ngokuvamile, i-HPMC ikhombisa i-soubity ephezulu emanzini nasePolar Solvents. I-HPMC inobubanzi besisindo se-molecular esingu-10,000 kuya ku-1,000,000 DA futhi imvamisa ine-soubity emanzini angu-1% kuya ku-5%, kuya ngebanga nangokuhlushwa. I-solubity ye-HPMC emanzini ithinteka yizici ezahlukahlukene ezifana ne-PH, lokushisa nokuhlushwa.
Ezihlalweni zokuhlanza izingubo, i-HPMC enezidingo eziphakeme ze-solubity kumele isetshenziselwe ukuqinisekisa ukucekelwa phansi okufanele kokuhlanza emanzini. I-solubity ye-HPMC kokuhlanza izingubo zokuhlanza ithinteka yizici eziningi, kufaka phakathi ubukhona bezinye izithako, izinga lokushisa lomjikelezo wokugeza kanye nobulukhuni bamanzi. Ubulukhuni bamanzi buthinta i-solubity ye-HPMC ngoba ukugxila okuphezulu kwamaminerali ancibilikisiwe, njenge-calcium ne-magnesium, kuphazamisa ukuchithwa kwe-HPMC emanzini.
Kubalulekile ukuthi ukhethe ibanga elifanele le-HPMC ngezidingo eziphakeme ze-solubity kanye nekhono lokumelana nezimo zokuwasha ezinzima. Amamaki we-HPMC anezidingo eziphakeme ze-solubity anconyelwe ukufakwa kwezingubo zokuhlanza ukuze aqinisekise ukuthi umkhiqizo unciphise kalula emanzini futhi uhlinzeka ngokusebenza okungaguquki kokuhlanza. Usebenzisa i-HPMC enezidingo eziphansi ze-solubity ingadala ukubambekela kube yi-clump futhi iqondise emanzini, kunciphise ukusebenza komkhiqizo.
I-solubity ye-HPMC ibalulekile ekusebenziseni kwayo kuzinhlobonhlobo zezicelo, kufaka phakathi okokuhlanza izingubo. I-solubity ye-HPMC emanzini ithinteka yizici eziningana, kufaka phakathi i-PH, lokushisa, kanye nokuhlushwa. Ezihlanzelweni zokuhlanza izingubo, i-HPMC enezidingo eziphakeme ze-solubity kumele isetshenziselwe ukuqinisekisa ukucekelwa phansi komkhiqizo emanzini. Usebenzisa i-HPMC enezidingo eziphansi ze-solubity ingadala ukubambekela kube yi-clump futhi kunciphise, kunciphise ukusebenza kahle komkhiqizo. Ngakho-ke, kuyadingeka ukuthi ukhethe amamaki afanelekayo we-HPMC ngezidingo eziphakeme ze-soundry zokuhlanza izingubo zokuqinisekisa ukusebenza okungaguquki.
Isikhathi sePosi: Sep-18-2023