Ukuqedwa kwe-hydroxypropyll methylcellulose (HPMC) emanzini kuwumkhuba ojwayelekile ezimbonini ezahlukahlukene, kufaka phakathi ama-Pharmaceuticals, ukudla, izimonyo kanye nokwakha. I-HPMC iyisixazululo se-cellulose eyakha isixazululo esibonakalayo, esingenamibala futhi esibonakalayo lapho ixubene namanzi. Lesi sixazululo sibonisa izakhiwo ezihlukile njengokuqina, ukubopha, ukushaya ifilimu, nokusekela ukukhishwa kwezithako ezisebenzayo. Inqubo yokuchithwa kwe-HPMC emanzini ifaka izinyathelo ezithile zokuqinisekisa ukusakazeka okufanele nokufana.
Isingeniso ku-HPMC:
I-Hydroxypropyl Methylcellulose (HPMC) yi-ether engeyona i-ether etholwa ku-polymer cellulose yemvelo. Ihlanganiswe ngokwelapha iselula nge-propelene oxide ne-methyl chloride. I-HPMC isetshenziswa kabanzi emikhakheni ehlukahlukene ngenxa yokuqina kwayo okuhle, ukuqina, ukuzinza, nokugcina izici zokugcina amanzi. Ukusetshenziswa okuyisisekelo kwe-HPMC kufaka:
Izemithi: Isetshenziswa njenge-binder, ifilimu langaphambili, i-viscosity modifier, ne-ejenti yokukhishwa okulawulwayo ezibhebheni, amaphilisi, amafutha, nokugcotshwa.
Imboni yokudla: Isetshenziswa njengoMkhulu, i-Stabilizer, e-Emulsifier, kanye nomswakama umswakama emikhiqizweni yokudla efana nososo, ubisi nezimpahla ezibhakiwe.
Ukwakha: Isebenza njenge-ejenti yokugcinwa kwamanzi, ukunamathela, kanye nokuqina kwezinto zokwenziwa kosimende, ama-gypsum asuselwa ku-gypSum, kanye nama-tile anamathela.
I-COSMETICS: IMISEBENZI EBUCHWEPHESHE, FIMOD FOMSTION STITILIZETILIZENDI-STITILIZETIWES ku-lotion, okhilimu, ama-shampoos kanye nemikhiqizo yokunakekelwa komuntu siqu.
Inqubo yokuqothula ye-HPMC emanzini:
Ukuqeda i-HPMC emanzini kubandakanya izinyathelo ezimbalwa ezibalulekile ukufezekisa isixazululo somfaniswano nesizinzile:
Ukukhetha kwebanga le-HPMC: Khetha ibanga elifanele le-HPMC ngokususelwa ku-viscosity oyifunayo, usayizi wezinhlayiyana, kanye nezinga lokufaka esikhundleni. Amabanga ahlukene anikeza ama-degree ahlukahlukene wokuvuleka kanye nezimpawu zokululube.
Ukulungiselela Amanzi: Sebenzisa amanzi ahlanziwe noma anciphile ukulungiselela isisombululo. Ikhwalithi yamanzi ingathinta kakhulu inqubo yokuqothula kanye nezakhiwo zesisombululo sokugcina. Gwema ukusebenzisa amanzi anzima noma amanzi aqukethe ukungcola okungaphazamisa ukuchithwa.
Isisindo nokulinganisa: Linganisa ngokunembile inani elidingekayo le-HPMC usebenzisa ibhalansi yedijithali. Ukuhlushwa okunconyiwe kwe-HPMC emanzini kuyahlukahluka ngokuya ngohlelo lokusebenza okuhlosiwe. Ngokuvamile, ukugxila okusukela ku-0,1% kuya ku-5% W / W kuvamile ukuthola izicelo eziningi.
I-Hydration Stage: Fafaza i-HPMC ephakathi kancane futhi ngokulinganayo ungene ebusweni bamanzi ngenkathi uvuselela ngokuqhubekayo. Gwema ukwengeza i-HPMC ngama-clumps amakhulu ukuvikela ukwakheka kwezigaxa noma ama-agglomerates. Vumela i-HPMC iyenze hydrate futhi isabalale kancane emanzini.
Ukuxuba nokuphazamiseka: Sebenzisa imishini yokuxuba efanelekile efana nesikhuthaka kazibuthe, i-propeller mixer, noma umxube omkhulu we-shear ukwenza lula ukuhlakazwa okufanayo kwezinhlayiya ze-HPMC emanzini. Gcina ukuphazamiseka okumnene ukuvikela ukonakala ngokweqile noma ukufakwa komoya.
Ukulawulwa kokushisa: qapha futhi ulawule izinga lokushisa ngesikhathi senqubo yokuchitheka. Ezimweni eziningi, amazinga okushisa egumbini (20-25 ° C) anele ukuqeda i-HPMC. Kodwa-ke, ngokuchithwa okusheshayo noma ukwakhiwa okuthile, amazinga okushisa aphakeme angadingeka. Gwema ngokweqile, ngoba kungalimaza i-polymer futhi kuthinte izakhiwo zezixazululo.
Isikhathi sokuchithwa: Ukuchithwa okuphelele kwe-HPMC kungathatha amahora ambalwa, kuya ngebanga, usayizi wezinhlayiyana, kanye nokuqina kokuphazamiseka. Qhubeka uvuse kuze kube yilapho isixazululo sicace, sobala, futhi singenazinhlayiya ezibonakalayo noma ezi-Ageglomerates.
Ukulungiswa kwe-PH (uma kunesidingo): Kwezinye izindlela, ukulungiswa kwe-PH kungadingeka ukwandisa ukuqina nokusebenza kwesisombululo se-HPMC. Sebenzisa ama-bejenti afanele ama-buffering noma alungise i-pH usebenzisa ama-acid noma izisekelo ngokwezidingo ezithile.
I-FILTRATION (Uma kudingeka): Ngemuva kokuchithwa okuphelele, hlunga isixazululo se-HPMC ngesihluthuli esihle se-mesh ngesihluthulelo noma sokuhlunga ukususa noma yiziphi izinhlayiya ezingalungiswa noma ukungcola. Lesi sinyathelo siqinisekisa ukucaca kanye ne-homogeneity yesisombululo.
Ukugcinwa nokuqina: gcina ikhambi le-HPMC elilungiselelwe kuhlanzekile, iziqukathi zezindiza kude nokukhanya kwelanga okuqondile kanye namazinga okushisa aphezulu. Izisombululo ezigciniwe kahle zihlala zizinzile ezikhathini ezengeziwe ngaphandle kwezinguquko ezibalulekile ekuboniseni noma kwezinye izakhiwo.
Izici ezithinta ukuchithwa kwe-HPMC:
Kunezici eziningana ezingathonya inqubo yokuqothula kanye nezindawo zesisombululo se-HPMC:
Ubukhulu bezinhlayiyana nebanga: amamaki afudumele amhlophe e-HPMC ancibilika kalula kunezinhlayiya ezihlanganayo ngenxa yendawo ekhuphukayo yendawo ephezulu.
Ukushisa: Amazinga okushisa aphezulu asheshisa izinga lokuchithwa kwe-HPMC kepha kungahle kuholele ekulahlekelweni kwe-Viscosity noma ukuwohloka kwezimo ezimbi kakhulu.
Isivinini sokuqashwa: Ukuqashwa okufanele kuqinisekisa ukuhlakazeka okufanayo kwezinhlayiya ze-HPMC futhi kukhuthaza ukuqedwa okusheshayo. Ukuphazamiseka ngokweqile kungangenisa ama-bubble omoya noma amagwebu esikhungweni.
Ikhwalithi Yamanzi: Izinga lamanzi asetshenziselwe ukuchithwa lithinta ukucaciswa, ukuqina, kanye nokubona kwekhambi le-HPMC. Amanzi ahlanjululwe noma ahlanziwe anconyelwa ukunciphisa ukungcola nama-ion angaphazamisa ukuchithwa.
I-PH: I-PH yesisombululo ingathonya i-solubity kanye nokuqina kwe-HPMC. Ukulungisa i-PH ngaphakathi kwebanga elifanele lebanga elithile le-HPMC lingathuthukisa ukuchithwa kanye nokusebenza.
Amandla we-Ionic: Ukugxila okuphezulu kosawoti noma i-ion kwikhambi kungaphazamisa ukuchithwa kwe-HPMC noma kubangele ukubheja. Sebenzisa amanzi e-deionized noma ulungise okugxiliwe usawoti njengoba kudingeka.
Amabutho we-Shear: Ukuxuba ukuxuba okuphezulu noma ukucubungula kungathinta izakhiwo ze-rheological kanye nokusebenza kwesisombululo se-HPMC, ikakhulukazi ezinhlalulweni zezimboni.
Izeluleko Zokuxazulula Izinkinga:
Uma uhlangabezana nobunzima ekuchitheni izingqinamba ze-HPMC noma isipiliyoni ngekhwalithi yesisombululo, cabanga ngezeluleko ezilandelayo zokuxazulula izinkinga:
Khulisa Agaturation: Thuthukisa ukuxubana kokuqina noma usebenzise imishini yokuxubha ekhethekile ukukhuthaza ukusakazwa okungcono nokuchithwa kwezinhlayiya ze-HPMC.
Lungisa izinga lokushisa
Ukwehliswa kosayizi wezinhlayiyana
Ukulungiswa kwe-PH: Bheka i-PH yesisombululo bese ulungisa njengoba kunesidingo sokugcina izimo ezifanele ze-HPMC Solbility kanye nokuqina.
Ikhwalithi Yamanzi: Qinisekisa ubumsulwa kanye nekhwalithi yamanzi asetshenziselwa ukuchithwa ngokusebenzisa i-filltration efanelekile noma izindlela zokuhlanza.
Ukuhlolwa kokuhambisana
Bheka imihlahlandlela yoMkhiqizi: Bheka izincomo zomkhiqizi kanye nemihlahlandlela yamamaki athile e-HPMC maqondana nemibandela yokuqothula, amabanga okuhlupha, kanye nezeluleko zokuxazulula inkinga.
I-Hydroxypropyll Methylcellulose (HPMC) emanzini iyisinyathelo esibalulekile ezinqumweni ezahlukahlukene zezimboni, kufaka phakathi amakhemikhali, ukudla, ukwakhiwa kanye nezimonyo. Ngokulandela izinqubo ezinconyiwe futhi ucubungule izinto ezibalulekile ezifana nosayizi wezinhlayiyana, izinga lokushisa, ukuguga kanye nekhwalithi yamanzi, ungathola isixazululo se-HPMC esifanayo. Ngokwengeziwe, amasu okuxazulula izinkinga namasu wokusebenza kahle angasiza ukunqoba izinselelo futhi aqinisekise ukuchithwa okuphumelelayo kwe-HPMC yezinhlelo zokusebenza ezahlukahlukene. Ukuqonda inqubo yokuqothula futhi kwayo
Isikhathi sePosi: Mar-09-2024