I-HPMC (i-hydroxypropyl methylcellulose) iwugqinsi futhi iyisinzisi evamise ukusetshenziswa ezintweni zokwakha, okokugqoka, kwezemithi nokudla. I-HPMC 15 cps isho ukuthi i-viscosity yayo ingu-15 centipoise, okuyibanga eliphansi le-viscosity.
1. Khulisa ukugxilisa ingqondo kwe-HPMC
Indlela eqondile nephumelelayo yokwandisa i-viscosity ye-HPMC ukukhulisa ukugxila kwayo esixazululweni. Lapho ingxenye enkulu ye-HPMC ikhuphuka, i-viscosity yesisombululo nayo izokhula. Umnyombo wale ndlela ukuthi i-HPMC ikhulisa i-viscosity yesixazululo ngokwenza isakhiwo senethiwekhi esinezinhlangothi ezintathu. Njengoba inani lama-molecule e-HPMC esixazululweni landa, ukuminyana namandla esakhiwo senethiwekhi kuzokwanda, ngaleyo ndlela kwandise i-viscosity yesisombululo. Kodwa-ke, kunomkhawulo wokwandisa ukugxila. Ukugxila okuphezulu kakhulu kwe-HPMC kuzobangela uketshezi lwesixazululo kwehle, futhi kungase kuthinte ngisho nokusebenza kwayo ezinhlelweni ezithile, njengokwakha nokusebenza.
2. Lawula izinga lokushisa lekhambi
Izinga lokushisa linomthelela omkhulu ku-solubility kanye ne-viscosity ye-HPMC. Emazingeni okushisa aphansi, i-viscosity yesisombululo se-HPMC iphakeme; ngenkathi emazingeni okushisa aphezulu, i-viscosity yesisombululo se-HPMC izokwehla. Ngakho-ke, ukwehlisa izinga lokushisa kwesisombululo ngokufanele ngesikhathi sokusetshenziswa kungandisa i-viscosity ye-HPMC. Kumele kuqashelwe ukuthi ukuncibilika kwe-HPMC kusixazululo kuhlukile emazingeni okushisa ahlukene. Ngokuvamile kulula ukuhlakazeka emanzini abandayo, kodwa kuthatha isikhathi esithile ukuhlakazeka ngokuphelele. Incibilika ngokushesha emanzini afudumele, kodwa i-viscosity iphansi.
3. Shintsha inani le-pH le-solvent
I-viscosity ye-HPMC nayo iyazwela kunani le-pH lesixazululo. Ngaphansi kwezimo ezingathathi hlangothi noma eziseduze, i-viscosity yesisombululo se-HPMC iphezulu kakhulu. Uma inani le-pH lesisombululo liphambuka ekungathathi hlangothi, i-viscosity ingase yehle. Ngakho-ke, i-viscosity yesisombululo se-HPMC inganyuswa ngokulungisa kahle inani le-pH lesixazululo (isibonelo, ngokungeza isigcinalwazi noma isilawuli se-acid-base). Nokho, ekusebenzeni kwangempela, ukulungiswa kwevelu ye-pH kufanele kuqaphe kakhulu, ngoba izinguquko ezinkulu zingabangela ukuwohloka kwe-HPMC noma ukwehla kokusebenza.
4. Khetha isincibilikisi esifanele
I-solubility kanye ne-viscosity ye-HPMC kumasistimu e-solvent ahlukene ahlukile. Nakuba i-HPMC isetshenziswa kakhulu ezixazululweni ezinamanzi, ukungezwa kwezinye izinyibilikisi zemvelo (njenge-ethanol, isopropanol, njll.) noma usawoti ohlukile kungashintsha ukwakheka kweketango le-molecule ye-HPMC, ngaleyo ndlela kuthinte i-viscosity. Isibonelo, inani elincane le-solvent ephilayo linganciphisa ukuphazanyiswa kwama-molecule amanzi ku-HPMC, ngaleyo ndlela kwandise i-viscosity yesisombululo. Emisebenzini ethile, kuyadingeka ukukhetha izinyibilikisi ezifanele ze-organic ngokusho kwesicelo sangempela.
5. Sebenzisa izinsiza zokujiya
Kwezinye izimo, ezinye izinsiza eziqinisayo zingangezwa ku-HPMC ukuze kuzuzwe umphumela wokwanda kwe-viscosity. Izinsiza zokujiya ezivame ukusetshenziswa zifaka i-xanthan gum, i-guar gum, i-carbomer, njll. Lezi zithasiselo zisebenzisana nama-molecule e-HPMC ukuze zakhe ijeli eliqinile noma isakhiwo senethiwekhi, ngokuqhubekayo ukwandisa i-viscosity yesisombululo. Isibonelo, i-xanthan gum iyi-polysaccharide yemvelo enomphumela oqinile wokujiya. Uma isetshenziswa ne-HPMC, lokhu okubili kungakha umphumela we-synergistic futhi kwandise ngokuphawulekayo i-viscosity yesistimu.
6. Shintsha izinga lokushintshwa kwe-HPMC
I-viscosity ye-HPMC nayo ihlobene nezinga lokushintshwa kwamaqembu ayo e-methoxy kanye ne-hydroxypropoxy. Izinga lokushintsha lithinta ukuncibilika kwayo kanye ne-viscosity yesisombululo. Ngokukhetha i-HPMC enamazinga ahlukene okushintsha, i-viscosity yesixazululo ingalungiswa. Uma i-viscosity ephakeme i-HPMC idingeka, umkhiqizo onokuqukethwe okuphezulu kwe-methoxy ungakhethwa, ngoba ukuphakama kokuqukethwe kwe-methoxy, i-hydrophobicity ye-HPMC inamandla, futhi i-viscosity ngemva kokuhlakazeka iphezulu kakhulu.
7. Nweba isikhathi sokuchithwa
Isikhathi lapho i-HPMC incibilika ngaso sizothinta i-viscosity yayo. Uma i-HPMC ingaqedwa ngokuphelele, i-viscosity yesisombululo ngeke ifinyelele esimweni esifanele. Ngakho-ke, ukwelula ngokufanelekile isikhathi sokuchithwa kwe-HPMC emanzini ukuze kuqinisekiswe ukuthi i-HPMC inamanzi ngokuphelele kungakhuphula ngempumelelo i-viscosity yesisombululo sayo. Ikakhulukazi uma incibilika kumazinga okushisa aphansi, inqubo yokuhlakaza ye-HPMC ingase ihambe kancane, futhi ukwelula isikhathi kubalulekile.
8. Shintsha izimo zokugunda
I-viscosity ye-HPMC nayo ihlobene namandla okugunda etholakala kuwo ngesikhathi sokusetshenziswa. Ngaphansi kwezimo eziphakeme zokugunda, i-viscosity yesisombululo se-HPMC izokwehla okwesikhashana, kodwa lapho i-shear ima, i-viscosity izolulama. Ngezinqubo ezidinga i-viscosity eyengeziwe, amandla okugunda lapho isixazululo singaphansi kwawo angancishiswa, noma angasetshenziswa ngaphansi kwezimo eziphansi zokugunda ukuze kugcinwe i-viscosity ephakeme.
9. Khetha isisindo esifanele samangqamuzana
Isisindo samangqamuzana e-HPMC sithinta ngqo i-viscosity yayo. I-HPMC enesisindo esikhulu samangqamuzana yakha isakhiwo senethiwekhi esikhulu esixazululweni, okuholela ekubonakaleni okuphezulu. Uma udinga ukukhulisa i-viscosity ye-HPMC, ungakhetha imikhiqizo ye-HPMC enesisindo samangqamuzana esiphezulu. Nakuba i-HPMC 15 cps ingumkhiqizo one-viscosity ephansi, i-viscosity ingakhuliswa ngokukhetha okuhlukile kwe-molecular-weight yomkhiqizo ofanayo.
10. Cabangela izici zemvelo
Izici zemvelo ezinjengomswakama nokucindezela zingase zibe nomthelela othile ku-viscosity yesisombululo se-HPMC. Endaweni enomswakama ophezulu, i-HPMC ingase imunce umswakama ovela emoyeni, ibangele i-viscosity yayo yehle. Ukuze ugweme lokhu, izimo zemvelo zokukhiqiza noma ukusetshenziswa kwesayithi zingalawulwa ngendlela efanele ukuze kugcinwe indawo eyomile kanye nengcindezi efanele yokugcina i-viscosity yesisombululo se-HPMC.
Kunezindlela eziningi zokwandisa i-viscosity yesixazululo se-HPMC 15 cps, okuhlanganisa ukugxilisa ingqondo okwandayo, ukulawula izinga lokushisa, ukulungisa i-pH, ukusebenzisa izinsiza zokuqina, ukukhetha izinga elifanele lokushintshwa nesisindo samangqamuzana, njll. Indlela ethize okufanele ikhethwe incike ekusetshenzisweni kwangempela. isimo kanye nezidingo zenqubo. Ekusebenzeni kwangempela, kuvame ukudingekile ukucabangela ngokucophelela izici eziningi futhi wenze izinguquko ezinengqondo nokulungiselelwa ukuze kuqinisekiswe ukusebenza okungcono kakhulu kwesisombululo se-HPMC ezinhlelweni ezithile.
Isikhathi sokuthumela: Oct-16-2024