I-HPMC ibizwa nge-hydroxypropyl methylcellulose.
Umkhiqizo we-HPMC ukhetha i-cotton cellulose emsulwa kakhulu njengempahla eluhlaza futhi wenziwa nge-etherification ekhethekile ngaphansi kwezimo ze-alkali.Yonke inqubo iqedwa ngaphansi kwezimo ze-GMP nokuqapha okuzenzakalelayo, ngaphandle kwezithako ezisebenzayo njengezitho zezilwane namafutha.
Izici ze-HPMC:
Umkhiqizo we-HPMC uyi-non-ionic cellulose ether, ukubukeka kuyimpushana emhlophe, akunambitheki, kuncibilika emanzini kanye nezinyibilikisi eziningi eziphila ezindaweni ezishisayo (njenge-dichloroethane) kanye nengxenye efanele ye-ethanol/amanzi, i-propyl alcohol/amanzi, njll. Isixazululo esimanzi singaphezulu umsebenzi, ukukhanya okuphezulu nokusebenza okuzinzile.I-HPMC inezici zejeli ezishisayo, isisombululo samanzi somkhiqizo siyashiswa ukuze senze i-gel precipitation, bese sihlakazwa ngemva kokupholisa, ukucaciswa okuhlukile kokushisa kwejeli komkhiqizo kuhlukile.I-Solubility ishintsha nge-viscosity, i-viscosity ephansi, ukuncibilika okukhulu, ukucaciswa okuhlukile kwe-HPMC kunomehluko othile ezindaweni zayo, i-HPMC emanzini ayithinteki ngenani le-PH.Usayizi we-particle: Izinga lokuphasa le-100 mesh likhulu kuno-100%.Ukuminyana kwenqwaba: 0.25-0.70g/ (imvamisa cishe u-0.5g/), amandla adonsela phansi athile 1.26-1.31.Izinga lokushisa lokushintsha umbala: 190-200 ℃, izinga lokushisa le-carbonization: 280-300 ℃.Ukushuba kobuso: 42-56dyn/cm kusixazululo samanzi esingu-2%.Ngokukhula kokuqukethwe kwe-methoxyl, iphuzu lejeli liyehla, ukuncibilika kwamanzi kwanda, nomsebenzi ongaphezulu nawo wanda.I-HPMC inezici zokuqina, usawoti, okuqukethwe komlotha ophansi, ukuzinza kwe-PH, ukugcinwa kwamanzi, ukuzinza kwe-dimensional, ukwakheka kwefilimu okuhle kakhulu kanye nokumelana okubanzi kwe-enzyme, ukuhlakazeka kanye nokuhlangana.
Izicelo ze-HPMC:
1. I-Tablet enamathela: I-HPMC esetshenziswa njengezinto zokumboza ifilimu ekulungiseleleni okuqinile, ingakha ifilimu eqinile, ebushelelezi futhi enhle, ukusetshenziswa kokuhlushwa kwe-2% -8%.Ngemuva kokumboza, ukuzinza kwe-ejenti ekukhanyeni, ukushisa nomswakama kuyanda;Akunambitheki futhi akunaphunga, kulula ukukuthatha, kanye ne-HPMC pigment, i-sunscreen, izinto zokuthambisa nokunye ukuhambisana okuhle kwezinto.Ukugqoka okuvamile: amanzi noma i-ethanol engu-30-80% yokuncibilikisa i-HPMC, enesixazululo esingu-3-6%, enezela izithako ezisizayo (njengokuthi: izinga lokushisa lomhlabathi -80, uwoyela we-castor, i-PEG400, i-talc, njll.).
2. Ungqimba oluhlukanisayo oluncibilikayo lwe-Enteric: ebusweni bamaphilisi kanye nama-granules, ukunamathela kwe-HPMC kuqala kusetshenziswa ungqimba olungezansi lokuhlukanisa, bese lumbozwa ngesendlalelo sezinto ezincibilikayo ze-HPMCP.Ifilimu ye-HPMC ingathuthukisa ukuzinza kwe-ejenti yokunamathela encibilikayo endaweni yokugcina.
3. Ukulungiswa kokukhishwa okuqhubekayo: kusetshenziswa i-HPMC njenge-ejenti efaka izimbotshana nokuthembela ku-ethyl cellulose njengento yamathambo, amaphilisi asebenza isikhathi eside angenziwa.
4. I-ejenti yokuqina kanye ne-colloid eyisivikelo enamathelayo kanye namaconsi esweni: I-HPMC ye-ejenti yokuqina evame ukusetshenziswa ukugxila kuka-0.45-1%.
5. I-Adhesive: I-HPMC njenge-binder general concentration ye-2% -5%, esetshenziselwa ukuthuthukisa ukuzinza kwe-adhesive hydrophobic, ukuhlushwa okuvame ukusetshenziswa kwe-0.5-1.5%.
6. I-ejenti yokubambezeleka, i-ejenti yokukhululwa elawulwayo kanye ne-ejenti yokumiswa.I-ejenti yokumiswa: umthamo ojwayelekile we-ejenti yokumiswa ngu-0.5-1.5%.
7. Ukudla: I-HPMC njenge-ejenti yokuqina yengezwe ezinhlobonhlobo zeziphuzo, imikhiqizo yobisi, izinongo, ukudla okunomsoco, njenge-ejenti yokuqina, isibopho, i-emulsifier, i-ejenti yokumiswa, i-stabilizer, i-ejenti yokugcina amanzi, i-excifer, njll.
8. Isetshenziselwa izimonyo njengezinamathiselo, ama-emulsifiers, ama-ejenti okwakha ifilimu, njll.
Isikhathi sokuthumela: Jan-14-2022