IHydroxypropyl Methylcellulose Phthalate(HPMCP) iwukuphuma kwe-cellulose eshintshiwe evame ukusetshenziswa embonini yezemithi. Itholakala ku-Hydroxypropyl Methylcellulose (HPMC) ngokuqhubeka nokuguqulwa kwamakhemikhali nge-phthalic anhydride. Lokhu kuguqulwa kunikeza izici eziyingqayizivele ku-polymer, okuyenza ifanelekele ukusetshenziswa okukhethekile ekwakhiweni kwezidakamizwa.

Nazi izici ezibalulekile kanye nokusetshenziswa kweHydroxypropyl Methylcellulose Phthalate:

1. I-Enteric Coating:
   • I-HPMCP isetshenziswa kabanzi njengento yokuhlanganisa i-enteric yamafomu omthamo womlomo njengamaphilisi namaphilisi.
   • I-Enteric coatings yenzelwe ukuvikela umuthi endaweni ene-asidi yesisu futhi yenze kube lula ukukhululwa endaweni ene-alkaline emathunjini amancane.
2. Ukunyibilika okuncike ku-pH:
   • Esinye sezici ezihlukile ze-HPMCP ukuncibilika kwayo okuncike ku-pH. Ihlala ingancibiliki ezindaweni ezine-acidic (pH ngaphansi kuka-5.5) futhi iyancibilika ezimeni ze-alkaline (pH ngaphezu kuka-6.0).
   • Lesi sakhiwo sivumela ifomu le-enteric-coated dosage ukuthi lidlule esiswini ngaphandle kokukhipha umuthi bese lincibilika emathunjini ukuze limunce izidakamizwa.
3. Ukumelana Nesisu:
   • I-HPMCP inikeza ukumelana nesisu, ukuvimbela umuthi ukuthi ungakhishelwa esiswini lapho ungase wehliswe khona noma ubangele ukucasuka.
4. Ukukhishwa okulawulwayo:
   • Ngokungeziwe ekuhlanganiseni kwe-enteric, i-HPMCP isetshenziswa ekwakhiweni kokukhishwa okulawulwayo, okuvumela ukulibaziseka noma ukukhululwa okunwetshiwe komuthi.
5. Ukuhambisana:
   • I-HPMCP ivamise ukusebenzisana nohlu olubanzi lwemithi futhi ingasetshenziswa ekwenziweni kwemithi ehlukahlukene.

Kubalulekile ukuqaphela ukuthi nakuba i-HPMCP isetshenziswa kabanzi futhi iyisisetshenziswa esisebenzayo se-enteric coating, ukukhetha kwe-enteric coating kuncike ezintweni ezifana nomuthi othile, iphrofayili yokukhululwa efiswayo, kanye nezidingo zesiguli. Abaqulunqi kufanele bacabangele izici ze-physicochemical kokubili kwesidakamizwa kanye ne-enteric coating material ukuze bazuze umphumela wokwelapha ofunekayo.

Njenganoma yisiphi isithako semithi, izindinganiso zokulawula kanye nemihlahlandlela kufanele ilandelwe ukuze kuqinisekiswe ukuphepha, ukusebenza kahle, kanye nekhwalithi yomkhiqizo wokugcina wemithi. Uma unemibuzo ethile mayelana nokusetshenziswa kwe-HPMCP esimweni esithile, kuyanconywa ukuthi uthintane nemihlahlandlela yezemithi efanele noma iziphathimandla ezilawulayo.