Ingabe i-hypromellose acid iyamelana?

I-Hypromellose, eyaziwa nangokuthi i-hydroxypropyl methylcellulose (HPMC), ayimelani ne-asidi ngokwemvelo. Kodwa-ke, ukumelana ne-asidi ye-hypromellose kungathuthukiswa ngamasu ahlukahlukene wokwenza.

I-Hypromellose iyancibilika emanzini kodwa ayincibiliki ezincibilikisini eziphilayo nasoketshezini olungezona i-polar. Ngakho-ke, ezindaweni ezine-asidi, njengesisu, i-hypromellose ingancibilika noma ivuvuke ngezinga elithile, kuye ngezici ezifana nokugcwala kwe-asidi, i-pH, kanye nesikhathi sokuchayeka.

Ukuze kuthuthukiswe ukumelana ne-asidi ye-hypromellose ekwakhekeni kwemithi, amasu okugcoba ama-enteric avame ukusetshenziswa. Izembatho ze-Enteric zisetshenziselwa amaphilisi noma ama-capsules ukuze zivikeleke endaweni ene-acidic yesisu futhi zivumele ukuba zidlule endaweni engathathi hlangothi yamathumbu amancane ngaphambi kokukhulula izithako ezisebenzayo.

I-Enteric coatings ngokuvamile yenziwa ngama-polymers amelana ne-gastric acid, njenge-cellulose acetate phthalate (CAP), i-hydroxypropyl methylcellulose phthalate (HPMCP), noma i-polyvinyl acetate phthalate (PVAP). Lawa ma-polymer akha isithiyo esivikelayo ezizungeze ithebhulethi noma i-capsule, evimbela ukubola ngaphambi kwesikhathi noma ukuwohloka kwesisu.

Kafushane, ngenkathi i-hypromellose ngokwayo ingamelana ne-asidi, ukumelana kwayo ne-asidi kungathuthukiswa ngokusebenzisa amasu okwakhiwa okufana ne-enteric coating. Lawa masu asetshenziswa ngokujwayelekile ekwenziweni kwemithi ukuze kuqinisekiswe ukulethwa okusebenzayo kwezithako ezisebenzayo endaweni okuhloswe ukuthi kwenziwe ngayo emzimbeni.