Ingabe i-hypromellose acid imelana?

I-Hypromellose, eyaziwa nangokuthi i-hydroxypropylllykylyl (HPMC), ayikho yini ukungamelana ne-acid. Kodwa-ke, ukumelana ne-acid kwe-hypromellose kungathuthukiswa ngokusebenzisa amasu ahlukahlukene awayo.

I-Hypromellose iyanyibilika emanzini kepha ingenakufakwa ku-organic solvents kanye noketshezi okungewona ama-polar. Ngakho-ke, ezindaweni ezine-acidic, njengesisu, i-hypromellose ingahle incibilike noma ivuvukale ngezinga elithile, kuya ngezinto ezifana ne-acid, pH, kanye nesikhathi sokuvezwa.

Ukuze uthuthukise ukumelana ne-acid ye-Hypromellose ekusungulweni kwemithi, amasu wokuhlanganisa ama-Enteric avame ukuqashwa. Izambatho ze-ENTERIC zisetshenziswa kumathebulethi noma amaphilisi ukuze zivikeleke kwimvelo ye-acid yesisu futhi zivumele ukuba zidlule endaweni engathathi hlangothi kwamathumbu amancane ngaphambi kokukhipha izithako ezisebenzayo.

Izambatho ze-ENTERIC zivame ukwenziwa kusuka kuma-polymers amelana ne-galtric acid e-phthalate (cap), i-hpdroxypropyly methylcellulose perthalate (hpmcp), noma i-polyvinyl acetate phthalate (PVAP). Lawa ma-polymers akha isithiyo esivikelekile esizungeze ithebhulethi noma i-capsule, ukuvimbela ukuqedwa ngaphambi kwesikhathi noma ukonakaliswa esiswini.

Ngamafuphi, ngenkathi i-Hypromellose ngokwayo akuyona i-acid elalimelana ne-acid, ukumelana ne-acid yayo kungathuthukiswa ngokusebenzisa amasu e-Exentric. Lawa masu asetshenziswa kakhulu ekwakhiweni kwemithi ukuqinisekisa ukulethwa okusebenzayo kwezithako ezisebenzayo kwisiza esihlosiwe sokusebenza emzimbeni.