I-Hydroxypropylmethylcelcelcelcellellulose (HPMC), njenge-hydrophilic polymer evame ukusetshenziswa embonini yezemithi, isetshenziswa kabanzi kuma-tablet coatings, ukwakheka okulawulwa kwezidakamizwa kanye nezinye izinhlelo zokulethwa kwezidakamizwa. Enye yezindawo ezibalulekile ze-HPMC yikhono layo lokugcina amanzi, okuthinta ukusebenza kwalo njenge-excipietical ye-yothi. Kulesi sihloko, sizohlola izinto ezibalulekile ezithinta ukugcinwa kwamanzi kwe-HPMC, kufaka phakathi isisindo se-molecular, uhlobo lokufakwa esikhundleni, ukugxilwa, kanye no-pH.
isisindo molecular
Isisindo se-molecular se-HPMC sidlala indima ebalulekile ekunqumeni umkhawulo wayo wokugcina amanzi. Ngokuvamile, i-High Molecular HPMC i-hpmmc eyengeziwe i-hydrophilic kune-HPMC ephansi ye-molecular HPMC futhi ingadonsa amanzi amaningi. Lokhu kungenxa yokuthi ama-HPMC aphezulu we-Molecular HPMC anamaketanga amade angafanisa futhi akha inethiwekhi ebanzi ngokwengeziwe, ekhulisa inani lamanzi angahle amunwe. Kodwa-ke, kufanele kuqashelwe ukuthi i-HPMC ephezulu kakhulu ye-HPMC izodala izinkinga ezinjengokubonakala kanye nokucubungula ubunzima.
okungenziwa esikhundleni sokunye
Enye into ethinta umthamo wokugcina amanzi we-HPMC uhlobo lokufaka esikhundleni. I-HPMC ivame ukuza ngezindlela ezimbili: i-hydroxypropyl-esikhundleni kanye ne-metholy-esikhundleni. Uhlobo olubuyiselwe esikhundleni se-hydroxypropyl lunamandla aphezulu wokutholwa kwamanzi kunohlobo olubuyiselwe esikhundleni se-methoxy. Lokhu kungenxa yokuthi iqembu le-hydroxypropyl likhona ku-molecule ye-HPMC yi-hydrophilic futhi lenyusa ubudlelwano be-HPMC ngamanzi. Ngokuphambene nalokho, uhlobo olubuyiselwe esikhundleni se-methoxy luncane i-hydrophilic futhi ngenxa yalokho inomthamo ophansi wokugcina amanzi. Ngakho-ke, ezinye izinhlobo ze-HPMC kufanele zikhethwe ngokucophelela ngokusekelwe kwizakhiwo ezifiselekayo zomkhiqizo wokugcina.
gxila ku
Ukuhlushwa kwe-HPMC kuthinta nomthamo wayo wokugcina amanzi. Ngokugxila okuphansi, i-HPMC ayikhi isakhiwo esinjengejeli, ngakho-ke umthamo wayo wokugcina amanzi uphansi. Njengoba ukugcwala kwe-HPMC kwanda, ama-molecule e-polymer aqala ukunxusa, akha isakhiwo esinjengegugu. Le nkunzi ye-gel imunca futhi igcine amanzi, futhi amandla okugcina amanzi we-HPMC akhuphuka ngokuhlushwa. Kodwa-ke, kufanele kuqashelwe ukuthi ukugxila okuphezulu kakhulu kwe-HPMC kuzoholela ezinkingeni zokwakha ezinjengokusobala nokucubungula ubunzima. Ngakho-ke, ukugcwaliseka kwe-HPMC okusetshenzisiwe kufanele kwenziwe kahle ukufeza amandla okugcina amanzi afisa ngenkathi ugwema izinkinga ezishiwo ngenhla.
Inani le-PH
Inani lemvelo lemvelo lapho kusetshenziswa khona i-HPMC izothinta nomthamo wayo wokugcina amanzi. Isakhiwo se-HPMC siqukethe amaqembu e-anionic (-Coo-) namaqembu e-Hydrophilic ethylcellulose (-OH). I-Ionization of -coo- Amaqembu ixhomekeke yi-PH ethembele, futhi iziqu zabo ze-Ionization zikhuphuka nge-PH. Ngakho-ke, i-HPMC inomthamo ophakeme wokugcina amanzi ku-PH PH. E-PH ephansi i-PH, i -cOo- Iqembu livikelwe futhi i-hydrophility yayo iyancipha, ibangele amandla aphansi okugcina amanzi. Ngakho-ke, i-PH yezemvelo kufanele yenziwe kahle ukufeza umthamo wokugcina wamanzi we-HPMC.
Ekuphetheni
Ekuphetheni, umthamo wokugcina amanzi we-HPMC yinto ebalulekile ethinta ukusebenza kwayo njenge-excipietical excipietical. Izici ezibalulekile ezithinta umthamo wokugcinwa kwamanzi we-HPMC zifaka isisindo se-molecular, uhlobo lokufakwa esikhundleni, ukugxilisa ingqondo nenani le-PH. Ngokushintsha ngokucophelela lezi zinto, umthamo wokugcina amanzi we-HPMC ungayenzelwe ukufeza izakhiwo ezifiselekayo zomkhiqizo wokugcina. Abacwaningi bezemithi kanye nabakhiqizi kufanele banake kakhulu lezi zinto ukuqinisekisa ikhwalithi ephezulu kakhulu kanye nokwenza ukusebenza kwezidakamizwa ezenzelwe i-HPMC.
Isikhathi sePosi: Aug-05-2023