I-Hydroxypropyl methylcellulose, eyaziwa ngokuthi i-HPMC, iyi-polymer eguquguqukayo, ehlukahlukene enezinhlobonhlobo zezicelo ezivela embonini ezifaka ukwakhiwa, amakhambi kanye nokudla. I-HPMC iyi-ether ye-cellulose, okusho ukuthi isuselwa ku-cellulose, i-polymer yemvelo etholakala ezitshalweni. Kuyinto esetshenziswa kakhulu i-celtulose ether ngenxa yezakhiwo zayo ezihlukile nezindleko eziphansi.
Ukuqedwa kwe-HPMC kungaba inqubo ekhohlisayo, ikakhulukazi lapho uzama ukuthola isisombululo esingathandeki futhi esingaguquguquki. Kulesi sihloko, sizoxoxa ngezinto ezithile ezibalulekile okufanele sikubone lapho sishoda i-HPMC yokuqeda ukuchithwa okuphumelelayo kanye nemiphumela efiselekayo.
1.Purity of HPMC
Ubumsulwa be-HPMC bungakuthinta kakhulu i-solubity yalo emanzini nakwamanye ama-solvents. Ngakho-ke, kubalulekile ukuqinisekisa ukuthi i-HPMC esetshenzisiwe yekhwalithi ephezulu nobumsulwa. I-HPMC engcoliswe ezinye izinto kungenzeka ingancibiliki kahle, okuholela ekutheni iziqu noma izigaxa kusisombululo. Lokhu kungathinta ukusebenza okuphelele kwemikhiqizo equkethe i-HPMC futhi kungadala izinkinga ngesikhathi senqubo yokwenza.
2. Inombolo yomkhiqizo we-HPMC
I-HPMC iyatholakala kumabanga ahlukene kanye namazinga we-viscosity, nebanga ngalinye elenzelwe uhlelo oluthile. Ibanga le-HPMC elisetshenzisiwe lizonquma inani le-HPMC elidingekayo kanye nokushisa kwalo kokuchithwa. Ngokuya ngebanga le-HPMC, izinga lokuchithwa nesikhathi kuzohluka. Ngakho-ke, kubalulekile ukuthi ufunde ngokucophelela futhi ulandele imiyalo yomenzi ephathelene nenani le-HPMC elizolisebenzisa futhi izinga lokushisa elidingekayo lokuchithwa okusebenzayo.
3. Solvent kanye lokushisa
Ukukhethwa kwe-solvent okusetshenzisiwe kanye nokushisa kwe-HPMC okulimazayo kuyizinto ezibalulekile ezithinta inqubo yokuchitheka. Amanzi yi-solvent esetshenziswa kakhulu ye-HPMC, futhi kubalulekile ukuqinisekisa ukuthi amanzi asetshenziswa ekhwalithi ephezulu futhi engenacala. Amanzi angcolile angaqukatha ukungcola okungathinta i-HPMC Solubity kanye nekhwalithi yomkhiqizo jikelele.
Izinga lokushisa lapho i-HPMC ichithwa nayo idlala indima ebalulekile. I-HPMC inciphisa okungcono emanzini afudumele, mhlawumbe phakathi kwama-80-90 degrees Celsius. Kodwa-ke, kufanele kuqashelwe ukuthi izinga lokushisa akufanele libe liphezulu kakhulu, uma kungenjalo i-HPMC izokwehliswa futhi idilizwe, iphuze ukwehla okubonakalayo nokusebenza kabi. Ngakho-ke, kubalulekile ukulawula ngokucophelela izinga lokushisa le-solvent ukuqinisekisa ukusebenza okungaguquki kanye nokusebenza kahle.
4. Hlanganisa futhi uvuse
Ukuxuba nokuphazamiseka kubalulekile ukuqinisekisa ukuqedwa okusebenzayo kwe-HPMC. Ukuxubana okuphelele nokuyaluza kuzosiza ukudiliza izinhlayiya ze-HPMC futhi kwakha ikhambi elimnandi nelingaguquki. Ngakho-ke, kubalulekile ukusebenzisa izindlela ezifanele zokuxuba, ezifana nabahlanganisi abaphezulu, ezisiza ukukhulisa amabutho wokuxuba kanye nesiphithiphithi kwikhambi.
5. Ukuhlushwa kwesisombululo se-HPMC
Ukuhlushwa kwe-HPMC ngesixazululo kuyinto ebalulekile okufanele uyicabangele lapho kuncibilika i-HPMC. Uma ukugxila kwe-HPMC kuphezulu kakhulu, kungadala ama-clumps noma ama-agglomerates ukuba akhethwe kwikhambi, okwenza kube nzima ukuthola isixazululo esifanayo. Ngakolunye uhlangothi, uma ukugxila kuphansi kakhulu, kungahle kube nomphumela wesisombululo esincibilikisiwe futhi sisebenza kahle.
Ekuphetheni
I-HPMC iyi-polymer eguquguqukayo futhi eguquguqukayo enezinhlelo zokusebenza ezahlukahlukene ezimbonini ezinjengezokwakha, ezemithi nokudla. Ukuchithwa kwe-HPMC kungaba inqubo ekhohlisayo, futhi kubalulekile ukubheka ngokucophelela izici ezinjengobumsulwa, ibanga, i-solvent, izinga lokushisa, ukuxuba, ukuxazulula, kanye nokuhlushwa kwesisombululo se-HPMC. Ukuchithwa okuphumelelayo nemiphumela efiselekayo kungatholakala ngokulandela imiyalo yomenzi nokulawula ngokucophelela lezi zinto.
Isikhathi sePosi: Sep-22-2023