I-Hydroxypropyl methylcellulose (HPMC) I-polymer esetshenziswa kakhulu ye-polymer, esetshenziswa kabanzi ekwakheni, emikhakheni, ukudla kanye nezinye izimboni. Njenge-polymer esolulekayo yamanzi, i-HPMC inokugcinwa kwamanzi okuhle kakhulu, ukwakha amafilimu, ukuqina kanye nokufaka izakhiwo. Ukugcinwa kwalo kwamanzi kungenye yezinto zayo ezibalulekile kuzinhlelo zokusebenza eziningi, ikakhulukazi ezintweni ezifana nosimende, udaka kanye nokugqoka embonini yezokwakha, kungabambezela ukuhwamuka kwamanzi futhi kuthuthukise ukusebenza kokwakha kanye nekhwalithi yomkhiqizo wokugcina kanye nekhwalithi yomkhiqizo wokugcina kanye nekhwalithi yomkhiqizo wokugcina. Kodwa-ke, ukugcinwa kwamanzi kwe-HPMC kuhlobene kakhulu noshintsho lokushisa endaweni yangaphandle, nokuqonda lobu budlelwano kubalulekile ukuthola uhlelo lokusebenza emikhakheni ehlukene.
1. Ukwakheka kanye nokugcinwa kwamanzi kwe-HPMC
I-HPMC yenziwa ukuguqulwa kwamakhemikhali kwe-cellulose yemvelo, ikakhulukazi ngokwethulwa kwe-hydroxypropylyl (-c3h7oh) namaqembu we-methyl (-CH3) eCellulose Chain, okunikezela nge-solubity kanye ne-regation Proceties. Amaqembu e-Hydroxyl (-OH) kuma-molecule we-HPMC angakha ama-hydrogen bond ngama-molecule wamanzi. Ngakho-ke, i-HPMC ingadonsa amanzi bese ihlangana namanzi, ikhombisa ukugcinwa kwamanzi.
Ukugcinwa kwamanzi kubhekisele emandleni ento yokugcina amanzi. Ku-HPMC, kubonakaliswa ikakhulukazi emandleni alo okugcina okuqukethwe kwamanzi ohlelweni nge-hydration, ikakhulukazi ezindaweni eziphakeme zokushisa noma ezindaweni eziphakeme zomswakama, ezingavimba ngempumelelo ukuphelelwa kwamanzi okusheshayo futhi kugcinwe nokungathathi kahle kwento. Njengoba i-hydration kuma-molecule we-HPMC ihlobene kakhulu nokuxhumana kwesakhiwo sayo samangqamuzana, izinguquko zokushisa zizothinta ngqo amandla okufakwa kwamanzi nokugcinwa kwamanzi kwe-HPMC.
2. Umphumela wokushisa kokugcinwa kwamanzi kwe-HPMC
Ubudlelwano phakathi kokugcinwa kwamanzi kwe-HPMC kanye nokushisa kungaxoxwa kusuka ezicini ezimbili: Omunye umphumela wokushisa ku-solubility ye-HPMC, kanti elinye lingumphumela wokushisa kwesakhiwo samangqamuzana kanye ne-hydration.
2.1 Umphumela Wokushisa ku-Solubity ye-HPMC
I-solubity ye-HPMC emanzini ihlobene nokushisa. Ngokuvamile, ukusondela kwe-HPMC kukhuphuka ngokushisa okuzayo. Lapho izinga lokushisa likhuphuka, ama-molekyuli amanzi athola amandla amaningi okushisa, okuholela ekubeni buthaka kokuxhumana phakathi kwama-molecule amanzi, ngaleyo ndlela akhuthaze ukuchitheka kwe I-HPMC. Ku-HPMC, ukukhuphuka kwamazinga okushisa kungenza kube lula ukwakha ikhambi le-colloidal, ngaleyo ndlela lenze ukugcinwa kwalo kwamanzi emanzini.
Kodwa-ke, izinga lokushisa eliphakeme kakhulu lingakhulisa ukubonakala kwesisombululo se-HPMC, okuthinta izakhiwo zalo ze-rhelogical kanye nokuhlakazwa. Yize lo mphumela unethemba lokuthuthuka kwe-solubity, izinga lokushisa kakhulu lingashintsha ukuqina kwesakhiwo salo se-molecular futhi kuholele ekunciphiseni kokugcinwa kwamanzi.
2.2 Umphumela wokushisa ohlelweni lwamangqamuzana we-HPMC
Esakhiweni samangqamuzana se-HPMC, amabhondi e-hydrogen akhiwa ikakhulukazi ngama-molecule wamanzi ngamaqembu ama-hydroxyl, futhi lesi sibopho se-hydrogen sibalulekile ekugcinweni kwamanzi kwe-HPMC. Njengoba izinga lokushisa likhuphuka, amandla e-hydrogen Bond angashintsha, okuholele ekunciphiseni amandla ahlanganayo phakathi kwe-molecule ye-HPMC ne-molecule yamanzi, ngaleyo ndlela kuthinta ukugcinwa kwamanzi. Ngokuqondile, ukwanda kwamazinga okushisa kuzodala ama-hydrogen bond ku-molecule ye-HPMC ukuze anciphise, ngaleyo ndlela anciphise ukumuncwa kwamanzi kanye nomthamo wokugcina amanzi.
Ngaphezu kwalokho, ukuzwela okushisa kwe-HPMC nakho kukhonjiswa ekuziphatheni kwesigaba kwesixazululo saso. I-HPMC enezinsimbi ezihlukile zamangqamuzana namaqembu ahlukene ahlukile anezinzwa ezihlukile zokushisa. Ngokuvamile, i-HPMC ephansi ye-molecular HPMC enozwela kakhulu ekushiseni, kuyilapho i-HPMC ephezulu ye-molecular HPMC ikhombisa ukusebenza okuzinzile. Ngakho-ke, kuzinhlelo zokusebenza ezisebenzayo, kuyadingeka ukuthi ukhethe uhlobo lwe-HPMC olufanele ngokuya ngobubanzi bezinyathelo ezithile ukuze uqinisekise ukugcinwa kwamanzi ekushiseni okusebenzayo.
2.3 Umphumela wokushisa kokuhwamuka kwamanzi
Endaweni ephezulu yokushisa, ukugcinwa kwamanzi kwe-HPMC kuzothinteka ekuhanjisweni kwamanzi okusheshayo okubangelwa ukwanda kwezinga lokushisa. Lapho izinga lokushisa langaphandle liphezulu kakhulu, amanzi ohlelweni lwe-HPMC kungenzeka ahwamuka. Yize i-HPMC ingagcina amanzi ngezinga elithile ngesakhiwo sayo samangqamuzana, izinga lokushisa eliphakeme ngokweqile lingadala ukuthi uhlelo luphelelwe amanzi ngokushesha kunomthamo we-HPMC. Kulokhu, ukugcinwa kwamanzi kwe-HPMC kuvinjelwe, ikakhulukazi emazingeni okushisa aphezulu nendawo eyomile.
Ukuze adambise le nkinga, ezinye izifundo zikhombise ukuthi ukwengeza ama-methamment avumelekile noma ukuguqula ezinye izinto kwifomula kungathuthukisa umphumela wokugcinwa kwamanzi endaweni yokushisa ephezulu. Isibonelo, ngokulungisa i-Viscocity Modifarier kwifomula noma ukukhetha i-solvent eguquguqukayo, ukugcinwa kwamanzi kwe-HPMC kungathuthukiswa ngezinga elithile, kunciphisa umphumela wokunyuka lokushisa kokuhwamuka kwamanzi.
3. Ukuthonya Izici
Umphumela wokushisa kokugcinwa kwamanzi kwe-HPMC axhomezeki ekushiseni okukhona kuphela, kodwa futhi nasesisindo samangqamuzana, izinga lokufaka esikhundleni, ukugxilisa izixazululo nakwezinye izinto ze-HPMC. Ngokwesibonelo:
Isisindo samangqamuzana:I-HPMC Ngokwesisindo esiphakeme se-molecular kuvame ukuba nokugcinwa kwamanzi okunamandla, ngoba isakhiwo senethiwekhi esakhiwa ngamaketanga we-molecular wesisindo esiphakeme kwikhambi lingadonsa futhi ligcine amanzi ngempumelelo.
Izinga lokufaka esikhundleni se-methylation: I-Hydroxypropylication ye-HPMC izothinta ukuxhumana kwayo ngama-molecule amanzi, ngaleyo ndlela kuthinte ukugcinwa kwamanzi. Ngokuvamile, isilinganiso esiphakeme sokufaka esikhundleni salokhu sithuthukisa i-hydrophicity ye-HPMC, ngaleyo ndlela sithuthukise ukugcinwa kwayo kwamanzi.
Ukuhlushwa kwesixazululo: Ukuhlushwa kwe-HPMC kuthinta nokugcinwa kwayo kwamanzi. Ukugxila okuphezulu kwezixazululo ze-HPMC kuvame ukuba nemiphumela engcono yokugcina amanzi, ngoba ukugxila okuphezulu kwe-HPMC kungagcina amanzi ngokusebenzisana okunamandla kwe-intermolecular intermolecular.
Kunobudlelwano obuyinkimbinkimbi phakathi kokugcinwa kwamanzi kweI-HPMCkanye nokushisa. Izinga lokushisa elikhulayo livame ukukhuthaza i-solubility ye-HPMC futhi kungaholela ekutheni kube lula ukugcinwa kwamanzi, kepha izinga lokushisa eliphakeme lizobhubhisa ukwakheka kwamangqamuzana kwe-HPMC, linciphise amandla alo okubopha amanzi, futhi ngaleyo ndlela lithinte umphumela walo wokugcina amanzi. Ukuze uzuze ukusebenza okuhle kakhulu kokugcinwa kwamanzi ngaphansi kwezimo zokushisa ezahlukahlukene, kuyadingeka ukuthi ukhethe uhlobo lwe-HPMC olufanele ngokuya ngezidingo ezithile zesicelo futhi ulungise izimo zalo zokusebenzisa. Ngaphezu kwalokho, ezinye izakhi ezisefomula kanye namasu okulawulwa kokushisa nazo zingathuthukisa ukugcinwa kwamanzi kwe-HPMC ezindaweni eziphakeme zokushisa zifinyelela ngezinga elithile.
Isikhathi sePosi: Nov-11-2024