I-HPMC noma i-Hydroxypropylm methylcellulose iyinto eguquguqukayo esetshenziswa ezinhlobonhlobo zezimboni ezifaka amakhambi, izimonyo nokudla. Kusetshenziswa kabanzi njenge-nyokener ne-emulsifier, futhi i-viscosity yayo iyashintsha ngokuya ngamazinga okushisa avezwa kuwo. Kulesi sihloko, sizogxila ebudlelwaneni phakathi kokuvunywa kanye nokushisa ku-HPMC.
I-Viscosity ichazwa njengesilinganiso sokumelana koketshezi ukuze ugeleze. I-HPMC iyinto eqinile eqinile ukulinganiswa kwayo okumelana nokumelana kuncike ezicini ezahlukahlukene, kufaka phakathi izinga lokushisa. Ukuqonda ubudlelwano phakathi kokuvunywa kanye nokushisa ku-HPMC, okokuqala kudingeka sazi ukuthi leyo nto yakhiwa kanjani nokuthi yenziwa kanjani.
I-HPMC isuselwa ku-cellulose, i-polymer eyenzeka ngokwemvelo ezitshalweni. Ukukhiqiza i-HPMC, i-cellulose idinga ukuguqulwa ngamakhemikhali nge-oxide ye-oxide ne-methyl chloride. Lokhu kuguqulwa kuphumela ekwakhekeni kwamaqembu we-hydroxypropyl kanye ne-methyl ether ecaleni le-cellulose. Umphumela uyinto eqinile eqinile engachithwa emanzini kanye ne-organic sollents futhi isetshenziswa ezinhlobonhlobo zezicelo, kufaka phakathi ukuhlanganiswa kwamathebulethi nanjenge-ejenti yokuqina kokudla, phakathi kwabanye.
I-viscosity ye-HPMC incike ekuqoqweni kwento kanye lokushisa lapho kudalulwa khona. Ngokuvamile, i-viscosity ye-HPMC yehla ngokuhlushwa okwandayo. Lokhu kusho ukuthi ukugxila okuphezulu kwemiphumela ye-HPMC ngama-viscosities aphansi kanye okuphambene nalokho.
Kodwa-ke, ubudlelwane obuphakathi nendawo phakathi kokuvunywa kanye nokushisa buyinkimbinkimbi ngokwengeziwe. Njengoba kushiwo ngaphambili, ukubonakala kwe-HPMC kukhuphuka ngokuncipha kokushisa. Lokhu kusho ukuthi lapho i-HPMC ifakwa emazingeni okushisa aphansi, amandla ayo okugeleza ayancipha futhi iba yi-viscous ngokwengeziwe. Ngokufanayo, lapho i-HPMC ifakwa emazingeni okushisa aphezulu, amandla ayo okugeleza kwandisiwe futhi ukubonakala kwayo kuyancipha.
Kunezici ezahlukahlukene ezithinta ubudlelwano phakathi kokushisa nokuvuleka ku-HPMC. Isibonelo, ezinye izithambeko ezikhona ku-ketshezi zingathinta ukubonakala, njengoba kungaba yi-PH ye-PH yoketshezi. Ngokuvamile, kepha kunobudlelwano obuhlukahlukene phakathi kokuvunywa kanye nokushisa ku-HPMC ngenxa yokushisa kwamazinga okushisa kwe-hpmc.
Lapho i-HPMC ifakwa emazingeni okushisa aphansi, amaketanga we-cellulose eba aqinile ngokwengeziwe, okuholela ekwandisweni kwe-hydrogen bonding. Lezi zibopho ze-hydrogen zibangela ukumelana kwento ukugeleza, ngaleyo ndlela kwandise ukubonakala kwalo. Ngakolunye uhlangothi, lapho ama-HPMCs afakwa ngaphansi kwamazinga okushisa aphezulu, amaketanga we-cellulose aguquguquka ngokwengeziwe, okuholele ekutheni kube nezibopho ezimbalwa ze-hydrogen. Lokhu kunciphisa ukumelana nomuthi ukugeleza, okuholela ekubonakaleni okuphansi.
Kuyaqapheleka ukuthi ngenkathi kuvame ubudlelwane obuhlukahlukene phakathi kokuvunywa kanye nokushisa kwe-HPMC, lokhu akunjalo ngaso sonke isikhathi kuzo zonke izinhlobo ze-HPMC. Ubudlelwano obuqondile phakathi kokubonakalayo kanye nokushisa kungahluka ngokuya ngenqubo yokukhiqiza kanye nebanga elithile le-HPMC elisetshenzisiwe.
I-HPMC yinto esebenza ngezinto eziningi esetshenziswa kabanzi kwizimboni ezahlukahlukene zokuqina kwayo nokukhulisa izakhiwo. I-viscosity ye-HPMC incike ezicini eziningana, kufaka phakathi ukufinyeleleka kwento kanye lokushisa lapho kudalulwa khona. Ngokuvamile, i-viscosity ye-HPMC ilingana ngaphakathi kwezinga lokushisa, okusho ukuthi njengoba izinga lokushisa lincipha, i-viscosity iyanda. Lokhu kungenxa yomphumela wokushisa kokuhlangana kwe-hydrogen bonding kanye nokusebenzisana kwama-molecular kwamaketanga we-cellulose ngaphakathi kwe-HPMC.
Isikhathi sePosi: Sep-08-2023