I-HPMC (Hydroxypropyl Methylcellulose)into evamile evame ukusetshenziswa kuma-capsules ejeli emithi (amaphilisi aqinile nathambile) anezinzuzo ezihlukahlukene eziyingqayizivele.
1. I-Biocompatibility
I-HPMC iwukuphuma kwe-cellulose yesitshalo semvelo esinokuhambisana okuhle kakhulu kwe-biocompatibility ngemva kokuguqulwa kwamakhemikhali. Ihambisana kakhulu nemvelo ye-physiological yomzimba womuntu futhi inganciphisa ngempumelelo ingozi yokungezwani komzimba. Ngakho-ke, kuvame ukusetshenziswa ekulungiseleleni izidakamizwa, ikakhulukazi ezidakamizweni ezidinga ukuthathwa isikhathi eside. Okubalulekile kwe-HPMC kunokucasuka okuncane emgudwini wesisu, ngakho-ke inokuphepha okuphezulu njengohlelo lokulethwa kwezidakamizwa, ikakhulukazi ekulungiseleleni ukukhishwa okuzinzile kanye nokukhishwa okulawulwayo kwezidakamizwa.
2. Izakhiwo zokukhululwa ezilungisekayo
I-HPMCingagcina ukuzinza kwayo ezindaweni ezihlukene (amanzi ne-pH), ngakho ifaneleka kakhulu ukulawula izinga lokukhululwa kwezidakamizwa. Kuma-capsules ejeli okwenza imithi, izakhiwo ze-HPMC zingalungiswa ngokushintsha izinga layo le-polymerization (isisindo samangqamuzana) kanye nezinga le-hydroxypropylation, okuyenza ibe ukukhetha okuhle kokulungiselela ukukhishwa okuzinzile kanye nokukhishwa okulawulwayo kwezidakamizwa. Kungabambezela ukukhululwa kwezidakamizwa ngokwenza ungqimba lwe-hydrated gelatinous material, ukuqinisekisa ukuthi izidakamizwa zingakhululwa ngokulinganayo nangokuqhubekayo ezingxenyeni ezihlukahlukene zomgudu wokugaya ukudla, ukunciphisa inani lemithi nokwandisa ukuthobela kweziguli.
3. Ayikho imvelaphi yesilwane, elungele abadla imifino
Ngokungafani namaphilisi e-gelatin endabuko, i-HPMC ithathwe ezitshalweni ngakho-ke ayinazo izithako zezilwane, okuyenza ifanele abantu abadla imifino kanye namaqembu izinkolelo zabo zenkolo ezingavumelani nezithako zezilwane. Ngaphezu kwalokho, amaphilisi e-HPMC abuye abonakale njengendlela evumelana nemvelo ngoba inqubo yawo yokukhiqiza ihambisana nemvelo futhi ayibandakanyi ukuhlatshwa kwezilwane.
4. Izakhiwo ezinhle zokwenza ifilimu
I-HPMCine-solubility enhle emanzini futhi ingakha ngokushesha ifilimu yejeli efanayo. Lokhu kuvumela i-HPMC ukuthi idlale indima ebalulekile ekwakhiweni kwefilimu yangaphandle ye-capsule. Uma kuqhathaniswa nezinye izinto, ukwakheka kwefilimu ye-HPMC kulula futhi kuzinzile, futhi akuthintwa kalula izinguquko zomswakama. Ingakwazi ukuvikela ngempumelelo izithako zezidakamizwa ku-capsule ukuthi zingathinteki imvelo yangaphandle futhi inciphise ukuchithwa kwezidakamizwa.
5. Lawula ukuzinza komuthi
I-HPMC inokumelana nokuswakama okuhle futhi ingavimbela ngempumelelo umuthi ekumunceni umswakama ku-capsule, ngaleyo ndlela ithuthukise ukuzinza komuthi futhi yelule isikhathi seshalofu somuthi. Uma kuqhathaniswa namaphilisi e-gelatin, amaphilisi e-HPMC mancane amathuba okuthi amunce amanzi, ngakho abe nokuzinza okungcono, ikakhulukazi ezindaweni ezinomswakama ophezulu.
6. Ukuncibilika okuphansi kanye nezinga lokukhululwa elihamba kancane
I-HPMC ine-solubility ephansi emgudwini wamathumbu, okwenza ukuthi incibilike kancane kancane esiswini, ngakho-ke ingaba khona esiswini isikhathi eside, elungele ukulungiswa kwezidakamizwa ezikhishwa ngokuqhubekayo. Uma kuqhathaniswa namaphilisi e-gelatin, amaphilisi e-HPMC anesikhathi eside sokuchithwa, esingaqinisekisa ukukhululwa okunembe kakhudlwana kwezidakamizwa emathunjini amancane noma kwezinye izingxenye.
7. Isebenza emalungiselelweni ezidakamizwa ahlukahlukene
I-HPMC iyahambisana nezinhlobonhlobo zezithako zezidakamizwa. Kungakhathaliseki ukuthi izidakamizwa eziqinile, izidakamizwa eziwuketshezi, noma izidakamizwa ezingancibiliki kahle, zingagqunywa ngempumelelo ngamaphilisi e-HPMC. Ikakhulukazi lapho ehlanganisa izidakamizwa ezincibilika kuwoyela, amaphilisi e-HPMC anokuvalwa nokuvikelwa okungcono, okungavimbela ngempumelelo ukuguquguquka nokuwohloka kwezidakamizwa.
8. Ukuncipha kokungezwani komzimba nemiphumela engemihle
Uma kuqhathaniswa namaphilisi e-gelatin, i-HPMC inezigameko eziphansi zokungezwani komzimba, okuyenza ibe ukukhetha okuhle kubantu abazwelayo ezithakweni zezidakamizwa. Njengoba i-HPMC ingenawo amaprotheni ezilwane, inciphisa izinkinga zokungezwani komzimba ezibangelwa izithako ezithathwe ezilwaneni futhi ifaneleka kakhulu iziguli ezingazwani ne-gelatin.
9. Kulula ukukhiqiza nokucubungula
Inqubo yokukhiqiza ye-HPMC ilula futhi ingenziwa ekamelweni lokushisa nokucindezela. Uma kuqhathaniswa ne-gelatin, inqubo yokukhiqiza yama-capsules e-HPMC ayidingi izinqubo eziyinkimbinkimbi zokulawula izinga lokushisa nezomisa, ukonga izindleko zokukhiqiza. Ngaphezu kwalokho, amaphilisi e-HPMC anamandla amahle okusebenza kanye nokuqina, futhi afanele ukukhiqizwa okuzenzakalelayo okukhulu.
10. Ukungafihli nokubukeka
Ama-capsules e-HPMC anokucaca okuhle, ngakho ukubukeka kwama-capsules kuhle kakhulu, okubaluleke kakhulu kwezinye izidakamizwa ezidinga ukubonakala okusobala. Uma kuqhathaniswa namaphilisi e-gelatin endabuko, amaphilisi e-HPMC anokucaca okuphezulu futhi angabonisa izidakamizwa kumaphilisi, okuvumela iziguli ukuthi ziqonde okuqukethwe kwezidakamizwa ngendlela enembile.
Ukusetshenziswa kweI-HPMCkuma-capsules wejeli wemithi anezinzuzo eziningi, okuhlanganisa i-biocompatibility enhle kakhulu, izici zokukhululwa kwezidakamizwa ezilungisekayo, ezifanele abantu abadla imifino, izici ezinhle zokwakheka kwefilimu, nokuzinza kwezidakamizwa okuthuthukisiwe. Ngakho-ke, isetshenziswa kakhulu embonini yezemithi, ikakhulukazi ekukhishweni okuqhubekayo, ukukhishwa okulawulwayo amalungiselelo ezidakamizwa kanye namalungiselelo ezidakamizwa asekelwe esitshalweni. Ngokukhula kwesidingo sabathengi sezempilo kanye nokuvikelwa kwemvelo, ithemba lemakethe lamaphilisi e-HPMC liya liba banzi.
Isikhathi sokuthumela: Nov-28-2024