IHypromellose, eyaziwa nangokuthi i-hydroxypropyl methylcellulose (HPMC), iyi-polymer esebenza ngezindlela eziningi etholakala ku-cellulose. Ngenxa yezakhiwo zayo eziyingqayizivele zamakhemikhali nezomzimba, i-HPMC ivamise ukusetshenziswa njenge-thickener, stabilizer kanye ne-adhesive embonini yezemithi, yokudla neyokunakekelwa komuntu siqu. Kulesi sihloko, sixoxa ngamakhemikhali e-HPMC kanye nezicelo zawo ezibalulekile.
1. Ukuncibilika
Enye yezinto ezibaluleke kakhulu zamakhemikhali ze-HPMC ukuncibilika kwayo. I-HPMC iyancibilika emanzini kanye nezincibilikisi eziningi eziphilayo, okuyenza ibe ingxenye ekahle yezinhlelo zokulethwa kwezidakamizwa nezinye izinhlelo zokusebenza ezidinga ukuhlakazwa. Kodwa-ke, ukunyibilika kwe-HPMC kunqunywa kakhulu izinga layo lokushintshwa (DS), elinquma inani lamaqembu e-hydroxypropyl kanye ne-methyl akhona ochungechungeni lwe-polymer. Ama-HPMC ane-DS ephezulu anokuncibilika okuphansi ngenxa yokwanda kokusebenzelana kwama-intermolecular.
2. I-Rheology
Enye impahla ebalulekile yamakhemikhali ye-HPMC ukuziphatha kwayo kwe-rheological. Amandla e-HPMC okwenza inethiwekhi efana nejeli lapho kudonswa amanzi angasetshenziswa ukulawula i-viscosity nezici zokugeleza kokwakheka. I-HPMC iphinde ibonise ukuziphatha kokugeleza okungekona okwe-Newtonian, okusho ukuthi i-viscosity yayo iyashintsha ngokuya ngesilinganiso sokugunda esisetshenzisiwe. Lesi sakhiwo singaqhubeka nokulawulwa ngokulungisa ukugxila kwe-HPMC kanye ne-DS ekwakhiweni.
3. Ukwakhiwa kwefilimu
I-HPMC iphinde isetshenziswe kabanzi njengefilimu yangaphambili ngenxa yekhono layo lokwenza amafilimu afanayo uma isetshenziswa ku-substrate. Izakhiwo zefilimu ze-HPMC zincike ku-DS yayo, i-viscosity kanye nokuba khona kwama-plasticizers, okungathuthukisa ukunwebeka nokuguquguquka kwefilimu. Amafilimu enziwe kusuka ku-HPMC avame ukusetshenziswa ekulethweni kwezidakamizwa ngoba avumela ukukhishwa okulawulwayo kwezithako ezisebenzayo.
4. Ukuvumelana
I-HPMC iyi-excipient ehambisana kakhulu futhi ingasetshenziswa ekuhlanganiseni okuhlukahlukene. Ihambisana nezithako eziningi zemithi, okuhlanganisa izithako ezisebenzayo zemithi (ama-API) nezinye izisetshenziswa ezivame ukusetshenziswa ekwenziweni kwemithi. I-HPMC futhi iyahambisana nezithako zokudla eziningi, okuyenza ibe ukukhetha okudumile kwezinhlelo zokudla.
5. Ukuzinza kwamakhemikhali
I-HPMC iyi-polymer ezinzile imelana ne-hydrolysis nokunye ukusabela kwamakhemikhali. Lokhu kuzinza kuyenza ibe isithako esifanelekile sezinhlelo zokulethwa kwezidakamizwa njengoba ivikela isithako esisebenzayo ekonakalisweni futhi kwandisa ukutholakala kwayo kwe-bioavailability. Kodwa-ke, ukuzinza kwamakhemikhali e-HPMC kungase kuthinteke izinga lokushisa eliphezulu, umswakama ophezulu, nezinyibilikisi ezithile, ezingabangela i-polymer ukuba ilulaze futhi inciphise ukusebenza kwayo ekubunjweni.
6. I-Biocompatibility
Okokugcina, i-HPMC iyi-polymer ehambisana kakhulu ne-biocompatible ephephile ukuthi isetshenziswe emikhiqizweni yokwelapha kanye nemikhiqizo yokunakekelwa komuntu siqu. Ayinabuthi, ayinawo amasosha omzimba futhi iyabola, okwenza ilungele ukwakheka okudinga ubuthi obuncane nokuphepha okuphezulu.
Kafushane, i-HPMC hypromellose iyi-polymer esebenzayo enohlu lwezindawo ezibalulekile zamakhemikhali, okuhlanganisa ukuncibilika, i-rheology, izakhiwo zefilimu, ukuhambisana, ukuzinza kwamakhemikhali, kanye ne-biocompatibility. Lezi zakhiwo zikwenza kube usizo olufanele lwezinhlelo zokulethwa kwezidakamizwa nezinye izinhlelo zokusebenza ezimbonini zokudla nezokunakekela komuntu siqu. Njengoba ucwaningo luqhubeka nokwandisa ukuqonda kwethu ama-HPMC, izakhiwo zawo ezihlukile zingathola izinhlelo zokusebenza ezibanzi esikhathini esizayo.
Isikhathi sokuthumela: Jul-28-2023