Yenziwe ngani i-hydroxypropyl methylcellulose?

IHydroxypropyl methylcellulose (HPMC) iyi-polymer eguquguqukayo futhi esetshenziswa kabanzi ezimbonini ezahlukahlukene, eyaziwa ngezindawo zayo ezihlukile kanye nokusetshenziswa kwayo. Le nhlanganisela iphuma ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo. Ukuze uqonde ukwakheka kwe-hydroxypropylmethylcellulose, kuyadingeka ukuphenya ngesakhiwo kanye nokuhlanganiswa kwalokhu okuphuma ku-cellulose.

Isakhiwo se-cellulose:

I-Cellulose i-carbohydrate eyinkimbinkimbi ehlanganisa uchungechunge lwamayunithi we-β-D-glucose axhunywe ngamabhondi e-β-1,4-glycosidic. Lawa maketango e-glucose ahlanganiswe ndawonye ngamabhondi e-hydrogen ukuze akhe isakhiwo esiqinile somugqa. I-Cellulose iyisakhi esiyinhloko sezindonga zamangqamuzana ezitshalo, enikeza amandla nokuqina kumaseli okutshala.

Izithako ze-Hydroxypropyl Methylcellulose:

I-Hydroxypropyl methylcellulose ihlanganiswa ngokushintsha i-cellulose amakhemikhali futhi yethule amaqembu e-hydroxypropyl kanye ne-methyl ochungechungeni oluyinhloko lwe-cellulose. Ukukhiqiza kuvame ukufaka izinyathelo ezilandelayo:

Impendulo esuka ku Etherification:

I-Methylation: Ukwelapha i-cellulose ngesisombululo se-alkaline ne-methyl chloride ukwethula amaqembu e-methyl (-CH3) kumaqembu e-hydroxyl (-OH) ye-cellulose.

I-Hydroxypropylation: I-cellulose ye-methylated iphinde iphendule nge-propylene oxide ukwethula amaqembu e-hydroxypropyl (-CH2CHOHCH3) esakhiweni se-cellulose. Le nqubo ithuthukisa ukuncibilika kwamanzi futhi ishintsha izakhiwo ezingokomzimba ze-cellulose.

ukuhlanzwa:

I-cellulose eguquliwe ibe isihlanzwa ukuze kukhishwe noma yiziphi izixube ezingaphenduliwe, imikhiqizo noma ukungcola.

Ukomisa nokugaya:

I-hydroxypropyl methylcellulose ehlanzekile yomiswa futhi igaywe ibe yimpushana elungele ukusetshenziswa ezintweni ezihlukahlukene.

Izithako ze-Hydroxypropyl Methylcellulose:

Ukwakhiwa kwe-hydroxypropyl methylcellulose kubonakala ngezinga lokushintshwa, okubhekisela ezingeni lapho amaqembu e-hydroxypropyl ne-methyl angena esikhundleni samaqembu e-hydroxyl ochungechungeni lwe-cellulose. Amabanga ahlukene e-HPMC anamadigri ahlukene okushintsha, athinta ukunyibilika kwawo, i-viscosity nezinye izakhiwo.

Ifomula yamakhemikhali ye-hydroxypropyl methylcellulose ingavezwa njengokuthi (C6H7O2(OH)3-mn(OCH3)m(OCH2CH(OH)CH3)n)_x, lapho u-m no-n emele izinga lokushintshwa.

m: idigri ye-methylation (amaqembu e-methyl ngeyunithi ngayinye ye-glucose)

n: izinga le-hydroxypropylation (amaqembu e-hydroxypropyl ngeyunithi ngayinye ye-glucose)

x: inani lamayunithi e-glucose kuketango le-cellulose

Izici Nezicelo:

Ukunyibilika: I-HPMC iyancibilika emanzini, futhi izinga lokushintsha lithinta izici zayo zokuncibilika. Yakha isixazululo esicacile nesine-viscous emanzini, okwenza kube lula ukwakheka okuhlukahlukene.

I-Viscosity: I-viscosity yesisombululo se-HPMC incike ezintweni ezifana nesisindo samangqamuzana kanye nezinga lokushintshwa. Lesi sakhiwo sibalulekile ezinhlelweni zokusebenza ezifana nemithi edinga ukwakhiwa kokukhishwa okulawulwayo.

Ukwakhiwa Kwefilimu: I-HPMC ingakha amafilimu amancanyana njengoba isixazululo somile, isenze sibe usizo ekuhlanganisweni kwezimboni zemithi, zokudla nezinye.

Ama-Stabilizers and Thickeners: Embonini yezokudla, i-HPMC isetshenziswa njenge-thickener ne-stabilizer emikhiqizweni eyahlukene, okuhlanganisa amasoso, ama-dessert, nezimpahla ezibhakwayo.

Izicelo Zemithi: I-HPMC isetshenziswa kakhulu ekwenziweni kwemithi, okuhlanganisa amaphilisi, amaphilisi, nezixazululo ze-ophthalmic, ngenxa yezakhiwo zayo zokukhishwa okulawulwayo kanye nokuvumelana kwe-biocompatibility.

Ukwakhiwa kanye nokuhlanganisa: I-HPMC isetshenziswa ezintweni zokwakha ezifana nodaka, izinto zokunamathisela zamathayela namapulasi. Ibuye isetshenziswe njenge-thickener kanye ne-stabilizer ekwenziweni kopende kanye nokwemboza.

Imikhiqizo Yokunakekela Umuntu: Embonini yezimonyo nokunakekela komuntu siqu, i-HPMC itholakala emikhiqizweni efana nokhilimu, izinto zokuthambisa kanye nama-shampoos, lapho inikeza khona ukuthungwa nokuzinza.

IHydroxypropyl methylcellulose itholakala nge-methylation kanye ne-hydroxypropylation ye-cellulose. I-polymer enezinjongo eziningi enezinhlobonhlobo zokusetshenziswa. Izakhiwo zayo eziyingqayizivele ziyenza ibe yigugu ezimbonini ezifana nemithi, ukudla, ezokwakha kanye nokunakekelwa komuntu siqu. Ukuguqulwa okulawulwayo kwe-cellulose kungalungisa kahle izakhiwo ze-HPMC, kuyenze ibe ingxenye ebalulekile yemikhiqizo eminingi esihlangabezana nayo ekuphileni kwethu kwansuku zonke.