IHydroxypropyl Methyl Cellulose (HPMC), eyaziwa nangokuthi i-hypromellose, iyi-polymer yokwenziwa etholakala ku-cellulose yemvelo. Umthombo oyinhloko we-cellulose ekukhiqizeni i-HPMC ngokuvamile ukhuni noma ukotini. Inqubo yokukhiqiza ibandakanya ukuguqula ngamakhemikhali i-cellulose ngokusebenzisa i-etherification, ukwethula i-hydroxypropyl namaqembu e-methyl kumgogodla we-cellulose.

Ukukhiqizwa kwe-HPMC kuhilela izinyathelo ezimbalwa:

1. Ukukhishwa kweCellulose:
   • I-cellulose itholakala emithonjeni yezitshalo, ikakhulukazi i-pulp yokhuni noma ukotini. I-cellulose ikhishwa futhi ihlanzwe ukuze yakhe i-cellulose pulp.
2. I-Alkalization:
   • I-cellulose pulp iphathwa ngesisombululo se-alkaline, ngokuvamile i-sodium hydroxide (NaOH), ukuze kusebenze amaqembu e-hydroxyl ochungechungeni lwe-cellulose.
3. I-Etherification:
   • I-Etherification isinyathelo esibalulekile ekukhiqizweni kwe-HPMC. I-alkalized cellulose ihlanganiswa ne-propylene oxide (yamaqembu e-hydroxypropyl) kanye ne-methyl chloride (yamaqembu e-methyl) ukwethula la maqembu e-ether kumgogodla we-cellulose.
4. Ukungathathi hlangothi kanye nokugeza:
   • I-cellulose eguquliwe ewumphumela, manje osekuyi-Hydroxypropyl Methyl Cellulose, ingena inqubo yokungathathi hlangothi ukuze isuse noma iyiphi i-alkali esele. Bese igezwa kahle ukuze kuqedwe ukungcola kanye nemikhiqizo.
5. Ukomisa Nokugaya:
   • I-cellulose eguquliwe yomiswa ukuze isuse umswakama owedlulele bese igaywa ibe yimpushana. Ubukhulu bezinhlayiyana bungalawulwa ngokusekelwe kuhlelo oluhlosiwe.

Umphumela womkhiqizo we-HPMC uyimpushana emhlophe noma emhlophe enamazinga ahlukene e-hydroxypropyl kanye nokushintshwa kwe-methyl. Izici ezithile ze-HPMC, njengokuncibilika kwayo, i-viscosity, nezinye izici zokusebenza, zincike ezingeni lokushintsha kanye nenqubo yokukhiqiza.

Kubalulekile ukuqaphela ukuthi i-HPMC i-semi-synthetic polymer, futhi ngenkathi isuselwa ku-cellulose yemvelo, ibhekana nokuguqulwa kwamakhemikhali okubalulekile phakathi nenqubo yokukhiqiza ukuze kuzuzwe izici zayo ezifiselekayo zezinhlelo zokusebenza ezihlukahlukene zezimboni.