I-Hydroxypropyl Methyl Cellulose (HPMC), eyaziwa nangokuthi i-Trade Name Hypromellose, iyi-polymer yokwenziwa etholakala ku-cellulose yemvelo. Umthombo oyinhloko we-cellulose yokukhiqizwa kwe-HPMC ngokujwayelekile uginindela wokhuni noma ukotini. Inqubo yokukhiqiza ifaka ukulungisa amakhemikhali ukuguqula i-cellulose ngokusebenzisa ukusheshisa, ukwethula i-hydroxypropyl kanye namaqembu we-methyl ku-cellulose backbone.

Ukukhiqizwa kwe-HPMC kubandakanya izinyathelo eziningana:

1. Ukukhishwa kwe-Cellulose:
   • I-cellulose itholakala emithonjeni yezitshalo, ngokuyinhloko ipulpiti yezinkuni noma ukotini. I-cellulose ikhishwe futhi ihlanzwe ukwakha i-cellulose pulp.
2. I-Alkalization:
   • I-cellulose pulp iphathwa ngesisombululo se-alkaline, imvamisa i-sodium hydroxide (NAOH), ukwenza kusebenze amaqembu e-hydroxyl ecaleni le-cellulose.
3. Ukuqothuka:
   • I-Eherification isinyathelo esiyisihluthulelo ekukhiqizweni kwe-HPMC. I-alkalised cellulose yenziwa nge-propelly oxide (yamaqembu we-hydroxypropy) kanye ne-methyl chloride (amaqembu we-methyl) ukwethula la maqembu ather emhlane.
4. Ukungathathi hlangothi nokugeza:
   • I-cellulose eguquliwe eguquliwe, okungukuthi manje i-hydroxypropyllylylylylylylylylylylylylylylylylyll, wehla inqubo yokungathathi hlangothi ukususa noma iyiphi i-alkali esele. Ngemuva kwalokho igezwa kahle ukuqeda ukungcola kanye nemikhiqizo.
5. Ukomisa nokugaya:
   • Iselula eguquliwe yomisiwe ukususa umswakama owengeziwe futhi ifakwe ku-powder enhle. Ubukhulu bezinhlayiyana bungalawulwa ngokususelwa kuhlelo lokusebenza okuhlosiwe.

Umkhiqizo we-HPMC ophumayo uwumpuphu omhlophe noma oshisekayo onamazinga ahlukahlukene ahlukahlukene we-hydroxypropyll kanye ne-methyl subini. Izakhiwo ezithile ze-HPMC, njenge-solubility yayo, i-viscosity, nezinye izici zokusebenza, zincike ngezinga lokufaka esikhundleni kanye nenqubo yokukhiqiza.

Kubalulekile ukuqaphela ukuthi i-HPMC iyi-polymer ye-semi-zokwenziwa, futhi ngenkathi itholakala ku-cellulose yemvelo, ithola ukuguqulwa okubalulekile kwamakhemikhali ngesikhathi senqubo yokukhiqiza ukuze kufinyelelwe izakhiwo ezifunwayo zezinhlelo zokusebenza ezahlukahlukene zezimboni.