I-Excipient Yezemithi
IHydroxypropyl methylcellulose (HPMC) imhlophe noma i-milky white, ayinaphunga, ayinambitheki, impushana ene-fibrous noma i-granule, ukuncipha kwesisindo lapho isomiswa akudluli u-10%, incibilika emanzini abandayo kodwa hhayi amanzi ashisayo, kancane kancane emanzini ashisayo Ukuvuvuka, ukupepsia, nokwenza i- isixazululo se-viscous colloidal, esiba yisixazululo lapho sipholile, futhi sibe ijeli lapho sishiswa.I-HPMC ayincibiliki ku-ethanol, i-chloroform ne-ether.Incibilika ku-solvent exubile ye-methanol ne-methyl chloride.Iphinde inyibilike ku-solvent exubile ye-acetone, i-methyl chloride ne-isopropanol nezinye izincibilikisi eziphilayo.Isixazululo saso esinamanzi singabekezelela usawoti (isixazululo saso se-colloidal asibhujiswa usawoti), futhi i-pH ye-1% yesisombululo samanzi ngu-6-8.Ifomula ye-molecular ye-HPMC yi-C8H15O8-( C10H18O6) -C815O, kanti isisindo se-molecular mass cishe yi-86,000.
I-HPMC inokuncibilika okuhle kakhulu kwamanzi emanzini abandayo.Ingancibilika ibe yisixazululo esisobala ngokunyakazisa kancane emanzini abandayo.Ngokuphambene nalokho, empeleni ayincibiliki emanzini ashisayo angaphezu kuka-60 ℃ futhi ingavuvukala kuphela.I-non-ionic cellulose ether.Isixazululo saso asinakho ukushaja kwe-ionic, asihlanganisi nosawoti wensimbi noma izinhlanganisela eziphilayo ze-ionic, futhi asisabelani nezinye izinto zokusetshenziswa phakathi nenqubo yokulungiselela;inezindawo eziqinile zokulwa ne-allergies, futhi ngokukhuphuka kwezinga lokushintshwa kwesakhiwo samangqamuzana, Iphikisana kakhulu ne-allergies futhi izinzile;futhi i-inert metabolism.Njengengxenye yezemithi, ayigaywa i-metabolized noma imuncwe.Ngakho-ke, ayinikezi ama-calories emithini nasekudleni.Inekhalori ephansi, ayinawo usawoti, futhi ayinawo usawoti ezigulini ezinesifo sikashukela.Izidakamizwa ezingezwani nokudla zinokusebenza okuyingqayizivele;izinzile uma kuqhathaniswa nama-acids nama-alkali, kodwa uma inani le-PH lidlula u-2~11 futhi lithintwa amazinga okushisa aphakeme noma linesikhathi eside sokulondoloza, i-viscosity yayo izokwehla;isixazululo saso esinamanzi singanikeza umsebenzi we-Surface, okubonisa ukungezwani kwendawo okumaphakathi kanye nokungezwani kobuso;ine-emulsification ephumelelayo ohlelweni lwezigaba ezimbili, ingasetshenziswa njenge-stabilizer ephumelelayo kanye ne-colloid evikelayo;isixazululo saso esinamanzi sinezinto ezinhle kakhulu zokwenza ifilimu, ithebhulethi kanye nephilisi Into enhle yokugqoka.Ukufakwa kwefilimu okwenziwe yikho kunezinzuzo zokungabi mbala nokuqina.Ukwengeza i-glycerin nakho kungathuthukisa ipulasitiki yayo.
Imikhiqizo ye-QualiCell HPMC ingathuthuka ngalezi zakhiwo ezilandelayo ku-Pharmaceutical Excipient:
·Uma inyibilika emanzini futhi ishintshashintsha ngesincibilikisi, i-HPMC yenza ifilimu ebonisa ngale enamandla aqine kakhulu.
·Ithuthukisa amandla okubopha .
·I-Hydrophilic matrix esetshenziswa kanye nama-hydrates e-HPMC ukuze kwakheke isendlalelo sejeli, elawula iphethini yokukhululwa kwezidakamizwa.
| Ncoma Ibanga: | Cela i-TDS |
| I-HPMC 60AX5 | Chofoza lapha |
| I-HPMC 60AX15 | Chofoza lapha |