I-HPMC (i-hydroxypropyl methylcellulose)ama-capsules angenye yezinto ezisetshenziswa kakhulu ze-capsule emithini yesimanje kanye nezithako zokudla. Isetshenziswa kakhulu embonini yezemithi kanye nemboni yomkhiqizo wokunakekelwa kwezempilo, futhi ithandwa ngabadla imifino kanye neziguli ezingezwani nokudla ngenxa yezithako zayo ezitholakala ezitshalweni. Ama-capsules e-HPMC ancibilika kancane kancane emgudwini wamathumbu ngemva kokuwadla, ngaleyo ndlela akhulule izithako ezisebenzayo kuwo.
1. Uhlolojikelele lwesikhathi sokuchithwa kwe-capsule ye-HPMC
Isikhathi sokuchithwa kwama-capsules e-HPMC ngokuvamile siphakathi kwemizuzu eyi-10 nengama-30, okuncike kakhulu ekushubeni kodonga lwe-capsule, inqubo yokulungiselela, imvelo yokuqukethwe kwe-capsule, nezici zemvelo. Uma kuqhathaniswa namaphilisi e-gelatin endabuko, izinga lokuqedwa lamaphilisi e-HPMC lihamba kancane, kodwa lisengaphakathi kwebanga elamukelekayo lomgudu wokugaya ukudla komuntu. Ngokuvamile, izidakamizwa noma izakhi zomzimba zingakhululwa ngokushesha futhi zimunce ngemva kokuba i-capsule ichithekile, iqinisekisa ukuthi i-bioavailability yezithako ezisebenzayo.
2. Izinto ezithinta izinga lokuqedwa lamaphilisi e-HPMC
Inani le-pH nezinga lokushisa
Amaphilisi e-HPMC anokuncibilika okungcono endaweni ene-acidic nengathathi hlangothi, ngakho-ke angancibilika ngokushesha esiswini. Inani le-pH lesisu ngokuvamile liphakathi kuka-1.5 no-3.5, futhi le ndawo ene-acidic isiza amaphilisi e-HPMC ukuthi ahlakazeke. Ngesikhathi esifanayo, izinga lokushisa elivamile lomzimba womuntu (37 ° C) lingakhuthaza ukuqedwa ngokushesha kwama-capsules. Ngakho-ke, endaweni ene-asidi yesisu, amaphilisi e-HPMC ngokuvamile angancibilika ngokushesha futhi akhulule okuqukethwe kwawo.
HPMC capsule odongeni ukujiya kanye ukuminyana
Ubukhulu bodonga lwe-capsule buthinta ngokuqondile isikhathi sokuchithwa. Izindonga zama-capsule aminyene zithatha isikhathi esengeziwe ukuncibilika ngokuphelele, kuyilapho izindonga zama-capsule ezincane zincibilika ngokushesha. Ngaphezu kwalokho, ukuminyana kwe-capsule ye-HPMC kuzophinde kuthinte izinga layo lokuqedwa. Ama-capsules aminyene azothatha isikhathi eside ukuthi aphule esiswini.
Uhlobo kanye nemvelo yokuqukethwe
Izithako ezilayishwe ngaphakathi kwe-capsule nazo zinomthelela othile kwizinga lokuchithwa. Isibonelo, uma okuqukethwe kune-acidic noma kuncibilika, i-capsule izoncibilika ngokushesha esiswini; kuyilapho kwezinye izithako ezinamafutha, kungase kuthathe isikhathi eside ukuhlakazeka. Ngaphezu kwalokho, izinga lokuqedwa kokuqukethwe okuyimpuphu noketshezi nalo lihlukile. Ukusatshalaliswa kokuqukethwe okuwuketshezi kufana kakhulu, okuvumela ukuhlakazeka ngokushesha kwama-capsules e-HPMC.
Usayizi we-Capsule
I-HPMCamaphilisi okucaciswa okuhlukile (okufana No. 000, No. 00, No. 0, njll.) anezilinganiso ezihlukene zokuchithwa. Ngokuvamile, amaphilisi amancane athatha isikhathi esifushane ukuncibilika, kuyilapho amaphilisi amakhulu anezindonga eziwugqinsi nokuqukethwe okwengeziwe, ngakho athatha isikhashana ukuncibilika.
Inqubo yokulungiselela
Ngesikhathi senqubo yokukhiqiza ama-capsules e-HPMC, uma kusetshenziswa ama-plasticizers noma ezinye izithako zengezwa, izici zokuchithwa kwama-capsules zingashintshwa. Isibonelo, abanye abakhiqizi bangeza i-glycerin yemifino noma ezinye izinto ku-HPMC ukuze kuthuthukiswe ukunwebeka kwamaphilisi, okungase kuthinte izinga lokuhlakazeka kwamaphilisi ngokwezinga elithile.
Umswakama nezimo zokugcina
Amaphilisi e-HPMC azwela umswakama nezimo zokugcina. Uma egcinwe endaweni eyomile noma eshisa kakhulu, ama-capsules angase abe brittle, ngaleyo ndlela aguqule izinga lokuhlakazeka esiswini somuntu. Ngakho-ke, amaphilisi e-HPMC ngokuvamile adinga ukugcinwa endaweni yokushisa ephansi kanye nendawo eyomile ukuze kuqinisekiswe ukuzinza kwezinga lokuchithwa kwawo kanye nekhwalithi.
3. Inqubo yokuchithwa kwama-capsules e-HPMC
Inqubo yokuqedwa kwamaphilisi e-HPMC ngokuvamile ihlukaniswe izigaba ezintathu:
Isigaba sokuqala sokumuncwa kwamanzi: Ngemva kokumunca, amaphilisi e-HPMC aqala ukumunca amanzi kujusi yesisu. Ubuso be-capsule buba manzi futhi kancane kancane buqala ukuthamba. Njengoba ukwakheka kwamaphilisi e-HPMC kunezinga elithile lokumuncwa kwamanzi, lesi sigaba sivamise ukushesha.
Isiteji sokuvuvukala nokuhlakazeka: Ngemva kokumunca amanzi, udonga lwe-capsule luyavuvukala lube ungqimba lwe-gelatinous. Lesi singqimba sibangela ukuba i-capsule iqhubeke nokuhlakazeka, futhi okuqukethwe kuyavezwa futhi kukhululwe. Lesi sigaba sinquma izinga lokuchithwa kwe-capsule futhi siyisihluthulelo sokukhululwa kwezidakamizwa noma imisoco.
Isigaba sokuqedwa esiphelele: Njengoba ukuhlakazeka kuqhubeka, i-capsule ihlakazwa ngokuphelele, okuqukethwe kukhishwa ngokugcwele, futhi kungamuncwa umzimba womuntu. Imvamisa phakathi kwemizuzu eyi-10 kuye kwengama-30, amaphilisi e-HPMC angaqeda inqubo ukusuka ekuhlakazweni kuya ekuqedeni ukuqedwa.
Inqubo yokulungiselela
Ngesikhathi senqubo yokukhiqiza ama-capsules e-HPMC, uma kusetshenziswa ama-plasticizers noma ezinye izithako zengezwa, izici zokuchithwa kwama-capsules zingashintshwa. Isibonelo, abanye abakhiqizi bangeza i-glycerin yemifino noma ezinye izinto ku-HPMC ukuze kuthuthukiswe ukunwebeka kwamaphilisi, okungase kuthinte izinga lokuhlakazeka kwamaphilisi ngokwezinga elithile.
Umswakama nezimo zokugcina
Amaphilisi e-HPMC azwela umswakama nezimo zokugcina. Uma egcinwe endaweni eyomile noma eshisa kakhulu, ama-capsules angase abe brittle, ngaleyo ndlela aguqule izinga lokuhlakazeka esiswini somuntu. Ngakho-ke, amaphilisi e-HPMC ngokuvamile adinga ukugcinwa endaweni yokushisa ephansi kanye nendawo eyomile ukuze kuqinisekiswe ukuzinza kwezinga lokuchithwa kwawo kanye nekhwalithi.
3. Inqubo yokuchithwa kwama-capsules e-HPMC
Inqubo yokuqedwa kwamaphilisi e-HPMC ngokuvamile ihlukaniswe izigaba ezintathu:
Isigaba sokuqala sokumuncwa kwamanzi: Ngemva kokumunca, amaphilisi e-HPMC aqala ukumunca amanzi kujusi yesisu. Ubuso be-capsule buba manzi futhi kancane kancane buqala ukuthamba. Njengoba ukwakheka kwamaphilisi e-HPMC kunezinga elithile lokumuncwa kwamanzi, lesi sigaba sivamise ukushesha.
Isiteji sokuvuvukala nokuhlakazeka: Ngemva kokumunca amanzi, udonga lwe-capsule luyavuvukala lube ungqimba lwe-gelatinous. Lesi singqimba sibangela ukuba i-capsule iqhubeke nokuhlakazeka, futhi okuqukethwe kuyavezwa futhi kukhululwe. Lesi sigaba sinquma izinga lokuchithwa kwe-capsule futhi siyisihluthulelo sokukhululwa kwezidakamizwa noma imisoco.
Isigaba sokuqedwa esiphelele: Njengoba ukuhlakazeka kuqhubeka, i-capsule ihlakazwa ngokuphelele, okuqukethwe kukhishwa ngokugcwele, futhi kungamuncwa umzimba womuntu. Imvamisa phakathi kwemizuzu eyi-10 kuye kwengama-30, amaphilisi e-HPMC angaqeda inqubo ukusuka ekuhlakazweni kuya ekuqedeni ukuqedwa.
Isikhathi sokuthumela: Nov-07-2024