IHydroxypropyl methylcellulose (HPMC), njengento ephuma ku-cellulose evamile, isetshenziswa kabanzi ekwakhiweni, kwezemithi, ekudleni, kumakhemikhali ansuku zonke nakwezinye izimboni. Izinga le-HPMC lahlulelwa kakhulu kusukela ezicini zezakhiwo zomzimba namakhemikhali, ukusebenza kokusebenza kanye nomthelela wokusetshenziswa.
1. Ukubukeka nombala
I-HPMC ivamise ukuba yimpushana emhlophe noma emhlophe noma ama-granules. Uma kukhona ushintsho oluphawulekayo lombala, njengokuphuzi, ukumpunga, njll., kungase kusho ukuthi ubumsulwa bayo abukho phezulu noma bungcolile. Ngaphezu kwalokho, ukufana kosayizi wezinhlayiyana kukhombisa nezinga lokulawula lenqubo yokukhiqiza. Izinhlayiya ezinhle ze-HPMC kufanele zisatshalaliswe ngokulinganayo ngaphandle kokuhlanganiswa okusobala noma ukungcola.
2. Ukuhlolwa kokuncibilika
I-HPMC inokuncibilika okuhle kwamanzi, okuyinkomba ebalulekile yokwahlulela ikhwalithi yayo. Ngokuhlolwa okulula kokuncibilika, ukunyibilika kwayo kanye ne-viscosity kungahlolwa. Izinyathelo zimi kanje:
Thatha inani elincane lempushana ye-HPMC, kancane kancane uyengeze emanzini abandayo noma emanzini okushisa kwegumbi, bese ubheka inqubo yayo yokuchithwa. I-HPMC yekhwalithi ephezulu kufanele ihlakazeke ngokulinganayo ngesikhathi esifushane ngaphandle kwemvula egelezayo esobala, futhi ekugcineni yakhe isixazululo se-colloidal esobala noma esithuthuma kancane.
Izinga lokuqedwa le-HPMC lihlobene nesakhiwo sayo samangqamuzana, izinga lokushintsha, kanye nobumsulwa benqubo. Ikhwalithi ephansi ye-HPMC ingase incibilike kancane futhi kalula yakhe amahlule okunzima ukubola.
3. Ukulinganisa kwe-viscosity
I-Viscosity ingenye yemingcele ebaluleke kakhulu yekhwalithi ye-HPMC. I-viscosity yayo emanzini ithintwa isisindo samangqamuzana kanye nezinga lokushintshwa, futhi ngokuvamile ikalwa nge-viscometer ejikelezayo noma i-capillary viscometer. Indlela ethize iwukuhlakaza inani elithile le-HPMC emanzini, ukulungisa isisombululo sokuhlushwa okuthile, bese ukala i-viscosity yesisombululo. Ngokusho kwedatha ye-viscosity, kungahlulelwa ukuthi:
Uma inani le-viscosity liphansi kakhulu, kungase kusho ukuthi isisindo samangqamuzana sincane noma sehlisiwe ngesikhathi senqubo yokukhiqiza;
Uma inani le-viscosity liphezulu kakhulu, kungase kusho ukuthi isisindo samangqamuzana sikhulu kakhulu noma ukushintshwa akulingani.
4. Ukutholwa kobumsulwa
Ukuhlanzeka kwe-HPMC kuzothinta ngqo ukusebenza kwayo. Imikhiqizo enokuhlanzeka okuphansi ngokuvamile iqukethe izinsalela eziningi noma ukungcola. Isinqumo sokuqala singenziwa ngezindlela ezilula ezilandelayo:
Ukuhlolwa kwensalela ekushiseni: Faka inani elincane lesampula le-HPMC esithandweni sokushisa esishisa kakhulu bese usishisa. Inani lezinsalela lingabonisa okuqukethwe kukasawoti wezinto ezingaphili nama-ion ensimbi. Izinsalela zekhwalithi ephezulu ze-HPMC kufanele zibe zincane kakhulu.
Ukuhlolwa kwenani le-pH: Thatha inani elifanele le-HPMC futhi ulincibilikise emanzini, futhi usebenzise iphepha lokuhlola i-pH noma imitha ye-pH ukukala inani le-pH lesixazululo. Ngaphansi kwezimo ezijwayelekile, isixazululo samanzi se-HPMC kufanele sisondele ekungathathi hlangothi. Uma kune-asidi noma i-alkaline, ukungcola noma imikhiqizo engase ibe khona ingase ibe khona.
5. Izakhiwo ezishisayo kanye nokuzinza kokushisa
Ngokushisisa isampula ye-HPMC, ukuqina kwayo okushisayo kungabonwa. I-HPMC yekhwalithi ephezulu kufanele ibe nokuzinza okuphezulu kokushisa ngesikhathi sokushisisa futhi akufanele ibole noma yehluleke ngokushesha. Izinyathelo ezilula zokuhlola ukusebenza kwe-thermal zifaka:
Shisisa inani elincane lesampula kupuleti elishisayo futhi ubheke indawo yalo encibilikayo kanye nezinga lokushisa lokubola.
Uma isampula iqala ukubola noma ukushintsha umbala ezingeni lokushisa eliphansi, kusho ukuthi ukuzinza kwayo okushisayo kubi.
6. Ukunqunywa kokuqukethwe komswakama
Umswakama ophezulu kakhulu we-HPMC uzophazamisa ukuqina nokusebenza kwayo kwesitoreji. Umswakama wayo unganqunywa ngendlela yesisindo:
Faka isampula ye-HPMC kuhhavini bese uyomisa ku-105℃ ukuze ube nesisindo esingashintshi, bese ubale umehluko wesisindo ngaphambi nangemuva kokumiswa ukuze uthole okuqukethwe komswakama. I-HPMC yekhwalithi ephezulu kufanele ibe nomswakamo ophansi, ngokuvamile olawulwa ngaphansi kuka-5%.
7. Izinga lokutholwa esikhundleni
Izinga lokushintshwa kwamaqembu e-methoxy kanye ne-hydroxypropoxy e-HPMC lithinta ngokuqondile ukusebenza kwayo, njengokuncibilika, izinga lokushisa lejeli, i-viscosity, njll. kwenziwe endaweni yaselabhorethri. Ngamafuphi, i-HPMC enokushintshwa okuphansi inokuncibilika okubi futhi ingase yakhe amajeli angalingani emanzini.
8. Ukuhlolwa kwezinga lokushisa kwe-gel
Izinga lokushisa lejeli le-HPMC izinga lokushisa elakha ngalo ijeli ngesikhathi sokushisisa. I-HPMC yekhwalithi ephezulu inebanga elithile lokushisa lejeli, ngokuvamile eliphakathi kuka-60°C no-90°C. Indlela yokuhlola izinga lokushisa lejeli yile:
Chaza i-HPMC emanzini, kancane kancane ukhuphule izinga lokushisa, futhi ubheke izinga lokushisa lapho ikhambi lishintsha lisuka ekubeni obala liye endaweni eyi-turbid, okuyizinga lokushisa lejeli. Uma izinga lokushisa lejeli liphuma ebangeni elivamile, kungase kusho ukuthi ukwakheka kwayo kwamangqamuzana noma izinga lokushintsha alihlangabezani nendinganiso.
9. Ukuhlolwa kokusebenza
Ukusebenza kohlelo lokusebenza lwe-HPMC ngezinjongo ezahlukahlukene kungase kuhluke. Isibonelo, embonini yezokwakha, i-HPMC ivame ukusetshenziswa njenge-ejenti yokugcina amanzi kanye ne-thickener. Ukusebenza kwayo kokugcina amanzi kanye nomphumela wokujiya kungahlolwa ngokuhlolwa kodaka noma kwe-putty. Ezimbonini zemithi nokudla, i-HPMC isetshenziswa njengefilimu yangaphambili noma impahla ye-capsule, futhi umphumela wayo wokwenza ifilimu kanye nezakhiwo ze-colloidal zingahlolwa ngokuhlolwa.
10. Iphunga kanye Nezinto Eziguquguqukayo
I-HPMC yekhwalithi ephezulu akufanele ibe nephunga elibonakalayo. Uma isampula linephunga elimnandi noma ukunambitheka kwangaphandle, kungase kusho ukuthi amakhemikhali angafuneki ethulwe phakathi nenqubo yokukhiqiza noma ukuthi iqukethe izinto eziguquguquka kakhulu. Ngaphezu kwalokho, i-HPMC yekhwalithi ephezulu akufanele ikhiqize amagesi acasulayo emazingeni okushisa aphezulu.
Izinga le-HPMC lingahlulelwa ngezivivinyo ezilula zomzimba ezifana nokubukeka, ukuncibilika kanye nesilinganiso se-viscosity, noma ngezindlela zamakhemikhali ezifana nokuhlola ubumsulwa nokuhlolwa kokusebenza okushisayo. Ngalezi zindlela, ukwahlulela kokuqala kungenziwa ngekhwalithi ye-HPMC, ngaleyo ndlela kuqinisekiswe ukusebenza kwayo okuzinzile ezinhlelweni zangempela.
Isikhathi sokuthumela: Sep-25-2024