Inkampani ye-Tiantai Cellulose igxile ocwaningweni, ekuthuthukisweni, ekukhiqizeni nasekukhuthazeni ukuthengisa kwemikhiqizo ye-hydroxypropyl methyl cellulose HPMC.Ukuhlanzeka kwe-HPMC hydroxypropyl methyl cellulose yisihloko somkhiqizo esithinteka kakhulu kubakhiqizi nabasebenzisi.Lapha singabakhiqizi be-hydroxypropyl methyl cellulose ukunikeza isingeniso esiningiliziwe, ngithemba ukufunda ukusiza.
Ukunqunywa kokuhlanzeka kwe-HPMC hydroxypropyl methyl cellulose
Isimiso
IHydroxypropyl methyl cellulose HPMC ayincibiliki ku-80% ethanol.Ngemva kokuncibilika nokuwashwa izikhathi eziningi, i-ethanol engu-80% encibilikisiwe kusampula iyahlukaniswa futhi ikhishwe ukuze kutholwe i-hydroxypropyl methyl cellulose ehlanzekile ye-HPMC.
Rozimisele
Ngaphandle kwalapho kushiwo ngenye indlela, ama-reagents kuphela aqinisekisiwe njengamanzi okuhlaziya ahlanzekile nacwengekile noma akhishwe nge-deionized noma amanzi ahlanzekile ngokuqhathaniswa azosetshenziswa ekuhlaziyeni.
95% ethanol (GB/T 679).
I-Ethanol, isixazululo esingu-80%, hlambulula u-95% we-ethanol (E.2.1) 840mL ngamanzi ku-1L.
I-BMI (GB/T 12591).
Ithuluzi
Izinsimbi zaselabhorethri ezivamile
I-Magnetic heat stirrer, ubude benduku enyakazayo bungaba ngu-3.5cm.
I-crucible yokuhlunga, 40mL, indawo yokuvula 4.5μm ~ 9μm.
Isitsha esingaphezulu kwengilazi, φ10cm, imbobo emaphakathi.
I-Beaker, 400mL.
Amazinga okushisa ajwayelekile okugeza amanzi.
Ihhavini, ingalawula izinga lokushisa ku-105℃±2℃.
Uhlelo
Kala ngokunembile isampula engu-3g (enembile kuye ku-0.001g) ebhekhani enesisindo esingaguquki, engeza u-150mL 80% ethanol ku-60℃ ~ 65℃, faka induku kazibuthe kuziqhumiso zokushisa kazibuthe, vala indishi engaphezulu, faka i-thermometer phakathi nendawo. hole, vula izinto zokufudumeza, lungisa isivinini esinyakazayo ukuze ugweme ukuchaphazeka, futhi ugcine izinga lokushisa liku-60℃ ~ 65℃.Ukugqugquzela imizuzu engu-10.
Misa ukunyakazisa, beka ibhakha kubhavu wamanzi wokushisa okungaguquki ongu-60℃ ~ 65℃, yima unganyakazi ukuze uxazulule indaba engancibiliki, bese uthela uketshezi olunamandla angaphezu kwavamile ngokuphelele ngangokunokwenzeka esitsheni esiqinile sokuhlunga.
Faka i-ethanol engu-150mL 80% ku-60 ℃ ~ 65 ℃ ku-beaker, phinda le misebenzi engenhla yokugqugquzela nokuhlunga, bese ugeza ibhakha, isitsha esingaphezulu, induku enyakazayo kanye ne-thermometer ngokucophelela ngo-80% ethanol ku-60℃ ~ 65℃, ukuze into engancibiliki idluliselwa ngokuphelele ku-crucible, futhi uqhubeke ugeza okuqukethwe kwe-crucible.Ukumunca kufanele kusetshenziswe phakathi nalokhu kusebenza futhi ukomiswa kwekhekhe kufanele kugwenywe.Uma izinhlayiya zidlula kusihlungi, ukumunca kufanele kwehliswe.
Qaphela: kufanele kuqinisekiswe ukuthi i-sodium chloride kusampula igezwe ngokuphelele yi-ethanol engu-80%.Uma kunesidingo, isixazululo esingu-0.1mol/L esisiliva se-nitrate kanye ne-6mol/L nitric acid singasetshenziswa ukuhlola ukuthi ifiltrate iqukethe ama-ion e-chloride.
Ezingeni lokushisa lasekamelweni, okuqukethwe kwe-crucible kwawashwa kabili nge-ethanol engu-95% ku-50mL, futhi ekugcineni nge-ethyl mi20mL yokuwashwa kwesibili.Isikhathi sokuhlunga akufanele sibe side kakhulu.I-crucible yafakwa ku-beaker futhi yashiswa kubhavu we-steam kuze kube yilapho kutholakala iphunga le-ethyl mi.
Qaphela: ukugeza nge-ethyl mi kuyadingeka ukususa ngokuphelele i-ethanol entweni engancibiliki.Uma i-ethanol ingasuswa ngokuphelele ngaphambi kokoma kuhhavini, ukususwa okuphelele akunakwenzeka ngesikhathi sokumiswa kwehhavini.
I-crucible ne-beaker zifakwa kuhhavini ku-105 ℃ ± 2 ℃ ukuze zomiswe amahora angu-2, bese zidluliselwa kumshini wokomisa ukuze zipholiswe i-30min futhi zikalwe, futhi zomiswa i-1h futhi zikalwe ukupholisa kuze kube yilapho ukuguqulwa kwesisindo kungabi ngaphezu kuka-0.003g. .Uma kwenzeka ukwanda kwesisindo ngesikhathi sokumiswa kwehora elingu-1, isisindo esibonwa esiphansi kakhulu siyoba khona.
Imiphumela ibaliwe
Ukuhlanzeka kwe-HPMC hydroxypropyl methyl cellulose kubalwe njengengxenye enkulu engu-P, futhi inani lavezwa njenge-%
I-M1 - inqwaba yento eyomile engancibiliki, ngamagremu (g);
I-M0 - Isisindo sengxenye yokuhlola, ngamagremu (g);
W0 - Umswakama nokuqukethwe okuguquguqukayo kwesampula, %.
Inani lencazelo ye-arithmetic lezilinganiso ezimbili ezifanayo lehliswa libe iphuzu elilodwa ledesimali njengomphumela wokulinganisa.
Pukulungiswa
Umehluko ophelele phakathi kwezilinganiso ezimbili ezizimele ezitholwe ngaphansi kwezimo zokuphindaphinda awukho mkhulu kuno-0.3%, inqobo nje uma okukhulu kuno-0.3% kungedluli u-5%.
Isikhathi sokuthumela: Feb-14-2022