Ngabe i-HPMC iyi-biopolymer?

I-Hydroxypropylmetylcellellellellellulose (HPMC) ukuguqulwa kwe-cellulose, i-polymer yemvelo etholakala ezindongeni zeseli zezitshalo. Ngenkathi i-HPMC ngokwayo ingeyona into eqinile njengoba ihlanganiswe ngamakhemikhali, kuvame ukubhekwa njenge-biopolymers engabantu noma eguquliwe.

A. Isingeniso se-hydroxypropyllym methylcellulose:

I-Hydroxypropyl methylcellulose (HPMC):

I-Hydroxypropylmethylcellellellulose (HPMC) iyisisulu se-cellulose, i-polymer eqondile eyakhiwe ngamayunithi we-glucose. I-Cellulose yingxenye enkulu yesakhiwo sezindonga zeseli zezitshalo. I-HPMC yenziwa ngokuguqula ngamakhemikhali ngokufaka i-hydroxypropyl kanye namaqembu we-methyl.

B. Ukwakheka nokusebenza:

Isakhiwo se-1.Chical:

Isakhiwo samakhemikhali se-HPMC siqukethe ama-cellulose backbone amayunithi athela ama-hydroxypropyl kanye namaqembu we-methyl. Izinga lokufaka esikhundleni (DS) lisho inani eliphakathi le-hydroxypropyl kanye namaqembu we-methyl ngamunye uphiko lwe-glucose ku-cellulose chain. Lokhu kuguqulwa kushintsha izakhiwo zomzimba nezamakhemikhali ze-cellulose, okuholele ebangeni lamabanga we-HPMC ngama-viscosities ahlukahlukene, i-solubity kanye nezakhiwo zejeli.

Izakhiwo ze-2.PHysical:

I-Solubinity: I-HPMC iyancibilika emanzini kanye nezinhlobo izixazululo ezicacile, okwenza kube yisithako esibalulekile ezinhlelweni ezahlukahlukene kufaka phakathi ama-Pharmaceuticals, ukudla, kanye nokwakha.

I-Viscosity: I-viscosity yesisombululo se-HPMC ingalawulwa ngokulungisa izinga lokufakwa esikhundleni kanye nesisindo se-polymer. Le mpahla ibalulekile ukuze kusetshenziswe izinhlelo ezinjengokwenziwa kwemithi kanye nezinto zokwakha.

3. Umsebenzi:

Ama-Fireners: I-HPMC isetshenziswa kakhulu njengomuntu omkhulu ekudleni, emikhakheni nemikhiqizo yokunakekelwa komuntu siqu.

Ukwakheka ifilimu: Kungakha amafilimu futhi kungasetshenziselwa amaphilisi wezokwelapha amakhampasi kanye namaphilisi, kanye nokukhiqiza amafilimu ngezinhlelo ezahlukahlukene.

Ukugcinwa kwamanzi: I-HPMC yaziwa ngezakhiwo zayo zokugcina amanzi, isiza ukuthuthukisa ukuzokwenza kanye ne-hydration yezinto zokwakha ezifana nemikhiqizo esekwe kore.

C. Ukusetshenziswa kwe-HPMC:

1. Izidakamizwa:

I-Tablet Coating: I-HPMC isetshenziselwa ukwenza izimbobo zethebhulethi ukulawula ukukhishwa kwezidakamizwa futhi kuthuthukiswe ukuqina.

Ukulethwa kwezidakamizwa ngomlomo: I-Biocomplity kanye nezindawo zokukhishwa ezilawulwayo ze-HPMC zenza zilungele izinhlelo zokulethwa kwezidakamizwa zomlomo.

Imboni ye-2.Constry:

Imikhiqizo yodaka kanye nosimende: I-HPMC isetshenziswa ezintweni zokwakha ukuthuthukisa ukugcinwa kwamanzi, ukusebenziseka kanye nokunamathelisa.

3. Imboni yokudla:

Abakhudlwana kanye nabazinzayo: I-HPMC isetshenziswa njengesikhulu kanye ne-stabilizer ekudleni ukuthuthukisa ukuthungwa nokuqina.

4. Imikhiqizo yokunakekelwa komuntu siqu:

Ukuqanjwa kwezimonyo: I-HPMC ifakwa ekunikezelweni kwezimonyo zezakhiwo zayo eziklanywe ngefilimu nezakhiwo.

5.Peraints kanye nokumbona:

I-Waterborne Coatings: Embonini yezambane, i-HPMC isetshenziswa ekwakhekeni kwamanzi ukuthuthukisa i-RHEOLOGY futhi ivikele ukuxazululwa kwezingulube.

6. Ukucatshangelwa Kwezemvelo:

Ngenkathi i-HPMC ngokwayo ingeyona i-polymer ephelele ye-bioderhradable, umsuka wayo we-mourlelic enza kube nobungani bemvelo ngokuqhathaniswa nama-polymers okwenziwa ngokugcwele. I-HPMC ingakwazi ukuba biodegade ngaphansi kwemibandela ethile, futhi ukusetshenziswa kwayo ekusungulweni okuzinzile futhi okungathandeki kuyindawo yocwaningo oluqhubekayo.

I-Hydroxypropylmethylcellellellellulose (HPMC) iyi-polymer eyenziwe ngama-semi-zokwenziwa asuselwa ku-cellulose. Izakhiwo zayo ezihlukile zikwenza zibalulekile kwizimboni ezahlukahlukene kufaka phakathi amakhemisi, ukwakhiwa, ukudla, ukunakekelwa komuntu siqu nopende. Yize kungeyona indlela ehlanzekile ye-biopolymer, imvelaphi yayo ye-cellulose kanye ne-biodegradation amandla ahambisana nesidingo esikhulayo sezinto ezikhulayo zezinto ezizinzile. Ucwaningo oluqhubekayo luyaqhubeka nokuhlola izindlela zokuqhakambisa ukuhambisana kwezemvelo kwe-HPMC futhi wandise ukusetshenziswa kwawo ekwakhekeni okunobungane kwemvelo.