IHydroxypropylmethylcellulose (HPMC) iwukuguqulwa kokwenziwa kwe-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo.Nakuba i-HPMC ngokwayo ingeyona nje i-biopolymer njengoba ihlanganiswa ngamakhemikhali, ivamise ukuthathwa njenge-semi-Synthetic noma i-modified biopolymers.
A. Isingeniso se-hydroxypropyl methylcellulose:
I-Hydroxypropyl methylcellulose (HPMC):
IHydroxypropylmethylcellulose (HPMC) iphuma ku-cellulose, i-polymer eqondile eyakhiwe amayunithi eglucose.I-Cellulose iyisakhi esiyinhloko sezindonga zamaseli ezitshalo.I-HPMC yenziwa ngokushintsha i-cellulose amakhemikhali ngokungeza i-hydroxypropyl namaqembu e-methyl.
B. Isakhiwo nokusebenza:
1.Isakhiwo samakhemikhali:
Isakhiwo samakhemikhali se-HPMC siqukethe amayunithi omgogodla we-cellulose ane-hydroxypropyl namaqembu e-methyl.I-Degree of substitution (DS) ibhekisela enanini elimaphakathi le-hydroxypropyl namaqembu e-methyl ngeyunithi ngayinye ye-glucose ochungechungeni lwe-cellulose.Lokhu kuguqulwa kushintsha izici ezingokomzimba nezamakhemikhali zeselulosi, okuholela ezinhlobonhlobo zamabanga e-HPMC anama-viscosity ahlukahlukene, ukunyibilika kanye nezimpawu zejeli.
2.Izakhiwo zomzimba:
Ukunyibilika: I-HPMC incibilika emanzini futhi yakhe izixazululo ezicacile, iyenze ibe isithako esibalulekile ekusetshenzisweni okuhlukahlukene okuhlanganisa imithi, ukudla, kanye nokwakha.
I-Viscosity: I-viscosity yesisombululo se-HPMC ingalawulwa ngokulungisa izinga lokushintshwa kanye nesisindo samangqamuzana e-polymer.Lesi sakhiwo sibalulekile ekusetshenzisweni okufana nokwakhiwa kwemithi nezinto zokwakha.
3. Umsebenzi:
Ama-thickeners: I-HPMC ivamise ukusetshenziswa njengokujiya ekudleni, emithini yemithi, nakwimikhiqizo yokunakekelwa komuntu siqu.
Ukwakhiwa Kwefilimu: Ingakha amafilimu futhi ingasetshenziselwa ukumboza amaphilisi emithi namaphilisi, kanye nokukhiqiza amafilimu ezinhlelo zokusebenza ezihlukahlukene.
Ukugcina Amanzi: I-HPMC yaziwa ngezindawo zayo zokugcina amanzi, esiza ukuthuthukisa ukusebenza kanye nokugeleza kwempahla yokwakha njengemikhiqizo esekwe usimende.
C. Ukusetshenziswa kwe-HPMC:
1. Izidakamizwa:
I-Tablet Coating: I-HPMC isetshenziselwa ukwenza izimbotshana zamathebulethi ukulawula ukukhishwa kwezidakamizwa kanye nokuthuthukisa ukuzinza.
Ukulethwa kwezidakamizwa ngomlomo: I-biocompatibility kanye nezakhiwo zokukhululwa ezilawulwayo ze-HPMC ziyenza ifanelekele amasistimu okulethwa kwezidakamizwa ngomlomo.
2.Imboni yezokwakha:
Imikhiqizo Yodaka Nosimende: I-HPMC isetshenziswa ezintweni zokwakha ukuze kuthuthukiswe ukugcinwa kwamanzi, ukusebenza kahle nokunamathela.
3. Imboni yokudla:
Ama-thickeners nama-Stabilizers: I-HPMC isetshenziswa njenge-thickener ne-stabilizer ekudleni ukuze kuthuthukiswe ukuthungwa nokuzinza.
4. Imikhiqizo yokunakekelwa komuntu siqu:
Ukwakhiwa Kwezimonyo: I-HPMC ifakwe ekwenziweni kwezimonyo ngenxa yezakhiwo zayo zokwenza ifilimu nokujiya.
5.Amapende nama-Coatings:
Izembatho zamanzi: Embonini yokumboza, i-HPMC isetshenziswa ekwakhiweni kwamanzi ukuze kuthuthukiswe i-rheology futhi kuvinjwe ukuhlaliswa kwe-pigment.
6. Ukucatshangelwa kwemvelo:
Nakuba i-HPMC ngokwayo ingeyona i-polymer ebolayo ngokuphelele, imvelaphi yayo ye-cellulosic iyenza ivumelane nemvelo uma iqhathaniswa nama-polymer okwenziwa ngokuphelele.I-HPMC ingakwazi ukubola ngaphansi kwezimo ezithile, futhi ukusetshenziswa kwayo ekwakhiweni okusimeme nokubolayo kuyindawo yocwaningo oluqhubekayo.
IHydroxypropylmethylcellulose (HPMC) iyi-polymer enemisebenzi eminingi etholakala ku-cellulose.Izakhiwo zayo eziyingqayizivele ziyenza ibe yigugu ezimbonini ezihlukahlukene ezihlanganisa ezemithi, ezokwakha, ukudla, ukunakekela komuntu siqu kanye nopende.Nakuba kungelona uhlobo oluhlanzekile lwe-biopolymer, umsuka wayo we-cellulose namandla okuwohloka kwe-biodegradation kuhambisana nesidingo esikhulayo sezinto ezisimeme ezisetshenziswayo ezihlukene.Ucwaningo oluqhubekayo luyaqhubeka nokuhlola izindlela zokuthuthukisa ukuhambisana kwemvelo kwe-HPMC nokwandisa ukusetshenziswa kwayo ekwakhiweni okunobungani kwemvelo.
Isikhathi sokuthumela: Feb-07-2024