Yiziphi izinhlobo ezahlukene ze-HPMC?

IHydroxypropyl Methylcellulose (HPMC) iyipolymer eguquguqukayo esetshenziswa ezimbonini ezahlukahlukene ezihlanganisa ezemithi, ezokwakha, ukudla, nezimonyo.Isuselwa ku-cellulose, i-polymer yemvelo etholakala ezitshalweni.I-HPMC yaziswa kakhulu ngokwenza ifilimu, ukuqina, ukuzinzisa, kanye nezindawo zokugcina amanzi.Embonini yezemithi, ivamise ukusetshenziswa njengesakhi semithi kumafomu omthamo womlomo, amalungiselelo e-ophthalmic, ukwakheka kwezihloko, kanye nezinhlelo zokulethwa kwezidakamizwa ezikhishwa okulawulwayo.

I-HPMC ingahlukaniswa ngokusekelwe kumapharamitha ambalwa okuhlanganisa isisindo sayo samangqamuzana, izinga lokushintshwa, kanye nosayizi wezinhlayiyana.Nakhu ukubuka konke kwezinhlobo ezahlukene ze-HPMC ngokusekelwe kulawa mapharamitha:

Ngokusekelwe ku-Molecular Weight:

I-High Molecular Weight HPMC: Lolu hlobo lwe-HPMC lunesisindo se-molecular ephakeme, okuholela ekuthuthukisweni kwe-viscosity kanye nezakhiwo zefilimu.Kuvame ukuthandwa ezinhlelweni lapho kudingeka khona i-viscosity ephezulu, njengasekwenziweni kokukhishwa okulawulwayo.

I-Low Molecular Weight HPMC: Ngokuphambene, i-HPMC enesisindo esiphansi se-molecular ine-viscosity ephansi futhi isetshenziswa ezinhlelweni lapho kufunwa khona i-viscosity ephansi kanye nokuqedwa ngokushesha.

Ngokusekelwe ku-Degree of Substitution (DS):

I-High Substitution HPMC (HPMC-HS): I-HPMC enezinga eliphezulu lokushintsha ngokuvamile ibonisa ukuncibilika okungcono emanzini futhi ingasetshenziswa ekuhlanganiseni okudinga ukuhlakazeka ngokushesha.

I-Medium Substitution HPMC (HPMC-MS): Lolu hlobo lwe-HPMC luhlinzeka ngebhalansi phakathi kokunyibilika nokubonakala.Ivame ukusetshenziswa ekwakhiweni kwemithi ehlukahlukene.

I-Low Substitution HPMC (HPMC-LS): I-HPMC enezinga eliphansi lokushintsha inikeza amanani ahamba kancane okuphela kanye ne-viscosity ephezulu.Ivamise ukusetshenziswa kumafomu omthamo wokukhishwa okuqhubekayo.

Ngokusekelwe kusayizi we-particle:

I-Fine Particle Size HPMC: I-HPMC enosayizi wezinhlayiyana ezincane inikeza izakhiwo zokugeleza ezingcono futhi ivame ukuthandwa ngamafomu omthamo oqinile njengamaphilisi namaphilisi.

I-Coarse Particle Size HPMC: Izinhlayiya eziqinile zilungele izinhlelo zokusebenza lapho ukukhishwa okulawulwayo noma izakhiwo zokukhishwa okunwetshiwe zifunwa khona.Zivame ukusetshenziswa kuma-matrix amaphilisi nama-pellets.

Amabanga Akhethekile:

I-Enteric HPMC: Lolu hlobo lwe-HPMC lwakhiwe ngokukhethekile ukuze lumelane noketshezi lwesisu, lukwazi ukudlula esiswini luphelele futhi lukhiphe umuthi emathunjini.Ngokuvamile isetshenziselwa izidakamizwa ezizwela i-pH yesisu noma ukulethwa okuhlosiwe.

I-HPMC Ekhishiwe Okuqhubekayo: Lezi zakhiwo ziklanyelwe ukukhulula isithako esisebenzayo kancane kancane esikhathini esinwetshiwe, okuholela esenzweni somuthi eside nokuncipha kwemvamisa yokudosa.Zivame ukusetshenziswa ezimweni ezingapheli lapho kubalulekile ukugcina amazinga ezidakamizwa njalo egazini.

Amabanga Ahlanganisiwe:

I-HPMC-Acetate Succinate (HPMC-AS): Lolu hlobo lwe-HPMC luhlanganisa izakhiwo ze-HPMC namaqembu e-acetyl, luyenze ifanelekele ukumbozwa kwama-enteric kanye nezinhlelo zokulethwa kwezidakamizwa ezizwela i-pH.

I-HPMC-Phthalate (HPMC-P): I-HPMC-P i-polymer encike ku-pH evamise ukusetshenziswa ezimbotsheni ze-enteric ukuvikela umuthi ezimeni ezine-asidi esiswini.

Izingxube ezenziwe ngokwezifiso:

Abakhiqizi bangase badale izingxube ezenziwe ngokwezifiso ze-HPMC namanye ama-polymer noma izinto ezisizayo ukuze kuzuzwe izimfuneko ezithile zokwakheka ezifana namaphrofayela athuthukisiwe okukhishwa kwezidakamizwa, ukuzinza okuthuthukisiwe, noma izici ezingcono zokufihla ukunambitheka.

izakhiwo ezihlukahlukene ze-HPMC zivumela ukusetshenziswa kwayo ezinhlobonhlobo zemikhiqizo yemithi, ngayinye yakhelwe ukuhlangabezana nezidingo ezithile ezifana nokuncibilika, i-viscosity, i-kinetics yokukhululwa, nokuzinza.Ukuqonda izinhlobo ezihlukene ze-HPMC nezici zayo kubalulekile ukuze abakhi bezakhiwo badizayine amasistimu okulethwa kwezidakamizwa asebenzayo futhi athuthukisiwe.