Ukumbozwa kwefilimu kuyinqubo ebalulekile ekwenziweni kwemithi, lapho kufakwa ungqimba oluncane lwe-polymer phezu kwamaphilisi noma amaphilisi.Lokhu kunamathela kusebenzela izinjongo ezihlukahlukene, okuhlanganisa ukuthuthukisa ukubukeka, ukufihla ukunambitheka, ukuvikela isithako esisebenzayo somuthi (API), ukulawula ukukhululwa, nokwenza lula ukugwinya.IHydroxypropyl Methylcellulose (HPMC) ingenye yamapolymer asetshenziswa kakhulu embotsheni yefilimu ngenxa yezakhiwo zayo eziguquguqukayo.
1.Izakhiwo ze-HPMC:
IHydroxypropyl Methylcellulose (HPMC) iyi-polymer etholakala ku-cellulose.Ibonakala ngokuncibilika kwayo emanzini, ikhono lokwenza ifilimu, nokuhambisana okuhle kakhulu nezithako ezehlukene zemithi.Izakhiwo ze-HPMC zingavunyelaniswa ngokushintsha amapharamitha afana nesisindo samangqamuzana, izinga lokushintshwa, kanye ne-viscosity.
Ikhono Lokwenza Ifilimu: I-HPMC inezinto ezinhle kakhulu zokwenza ifilimu, ezivumela ukwakheka komfaniswano nokunamathela okubushelelezi ebusweni bamafomu omthamo wemithi.
Ukunyibilika Kwamanzi: I-HPMC ikhombisa ukuncibilika kwamanzi, okuvumela ukuchithwa kwe-polymer ezixazululweni ezinamanzi phakathi nenqubo yokumboza.Lesi sakhiwo siqinisekisa ukusatshalaliswa okufanayo kwe-polymer futhi kusiza ukwakheka kwesendlalelo sokuhlanganisa okulinganayo.
Ukunamathela: I-HPMC ibonisa ukunamathela okuhle ebusweni bamaphilisi noma ama-capsules, okuholela ekugqokeni okuqinile okunamathela kahle ku-substrate.
Izakhiwo Zokunqanda: I-HPMC inikeza umgoqo ngokumelene nezici zemvelo ezifana nomswakama, umoya-mpilo, nokukhanya, ngaleyo ndlela ivikela ubuqotho befomu lomthamo futhi ithuthukisa ukuzinza.
2. Ukucatshangelwa kokwakhiwa:
Ekwakheni isixazululo sokumboza ifilimu kusetshenziswa i-HPMC, izici ezimbalwa zidinga ukucatshangelwa ukuze kuzuzwe izici ezifiselekayo zokumboza nokusebenza.
I-Polymer Concentration: Ukugxila kwe-HPMC kusixazululo sokumboza kuthonya ukushuba kanye nezakhiwo zemishini zefilimu.Ukugxila okuphezulu kwe-polymer kubangela ukunamathela okuqinile okunezici zokuvimbela ezithuthukisiwe.
Ama-Plasticizers: Ukwengezwa kwama-plasticizers afana ne-polyethylene glycol (PEG) noma i-propylene glycol (PG) kungathuthukisa ukuguquguquka nokunwebeka kwengubo, kuyenze ibe yi-brittle futhi imelane kakhulu nokuqhekeka.
Izincibilikisi: Ukukhethwa kwezinyibilikisi ezifanele kubalulekile ukuze kuqinisekiswe ukunyibilika kwe-HPMC kanye nokwakheka kwefilimu efanele.Izincibilikisi ezivamile zihlanganisa amanzi, i-ethanol, i-isopropanol, nezingxube zayo.
Ama-Pigments nama-Opacifiers: Ukufakwa kwe-pigments nama-opacifier ekwakhiweni kwe-coating kunganikeza umbala, kuthuthukise ukubukeka, futhi kunikeze ukuvikeleka okukhanyayo emithini ebucayi.
3.Izicelo ze-HPMC ku-Film Coating:
Izingubo ezisekelwe ku-HPMC zithola ukusetshenziswa okubanzi ezimbonini zemithi nezomsoco ngenxa yokuguquguquka kwazo kanye nokufaneleka kwamafomu emithamo ahlukahlukene.
Izingubo Zokukhishwa Ngokushesha: Izembatho ze-HPMC zingasetshenziswa ukunikeza ukukhululwa ngokushesha kwezidakamizwa ngokulawula amazinga okuhlakazeka nokuhlakazeka kwamaphilisi noma amaphilisi.
Izingubo Zokukhishwa Ezilungisiwe: Ukwakheka okususelwe ku-HPMC kuvamise ukusetshenziswa kumafomu omthamo wokukhishwa alungisiwe, okuhlanganisa ukukhishwa okunwetshiwe kanye nokwakheka kwe-enteric-coated.Ngokushintsha i-viscosity nokuqina kwentolo, iphrofayili yokukhululwa yomuthi ingalungiswa ukuze kuzuzwe ukukhululwa okuqhubekayo noma okuhlosiwe.
I-Taste Masking: Izembatho ze-HPMC zingafihla ukunambitheka okungajabulisi kwezidakamizwa, kuthuthukise ukuthobela kwesiguli nokwamukelwa kwamafomu omthamo womlomo.
Ukuvikela Umswakama: Izembatho ze-HPMC zinikeza ukuvikeleka okusebenzayo komswakama, ikakhulukazi emithini ye-hygroscopic ethanda ukuwohloka lapho echayeka kumswakama.
Ukuthuthukisa Ukuzinza: Izembatho ze-HPMC zinikeza umgoqo ovikelayo ngokumelene nezici zemvelo, ngaleyo ndlela kuthuthukisa ukuzinza nempilo yeshalofu yemikhiqizo yemithi.
IHydroxypropyl Methylcellulose (HPMC) idlala indima ebalulekile ekusetshenzisweni kokumboza ifilimu embonini yezemithi.Izakhiwo zayo eziyingqayizivele, ezihlanganisa ikhono lokwenza ifilimu, ukunyibilika kwamanzi, ukunamathela, kanye nezakhiwo zokuvimbela, kuyenza ibe inketho ekahle yokwenza ama-coatings anemisebenzi ehlukahlukene.Ngokuqonda ukucatshangelwa kokwakhiwa kanye nokusetshenziswa kwe-HPMC ekuhlanganisweni kwefilimu, abakhiqizi bemithi bangakha amafomu omthamo ngokusebenza okuthuthukisiwe, ukuzinza, nokwamukelwa kwesiguli.
Isikhathi sokuthumela: Mar-07-2024