IHydroxypropyl methylcellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa kabanzi ezimbonini ezahlukahlukene, kufaka phakathi ezemithi, izimonyo, ukudla, nezokwakha.Ikhono layo lokwenza amajeli, amafilimu, nezisombululo liyenza ibe wusizo ezinhlelweni eziningi.Ukufakwa kwamanzi kwe-HPMC kuyisinyathelo esibalulekile ezinqubweni eziningi, njengoba kwenza i-polymer ibonise izakhiwo zayo ezifisayo ngempumelelo.
1. Ukuqonda i-HPMC:
I-HPMC iphuma ku-cellulose futhi ihlanganiswa ngokwelapha i-cellulose nge-propylene oxide ne-methyl chloride.Ibonakala ngokuncibilika kwayo emanzini kanye nekhono lokwakha ama-gel obala, ahlehliswa ngokushisa.Izinga le-hydroxypropyl ne-methoxyl esikhundleni lithinta izici zayo, okuhlanganisa ukuncibilika, i-viscosity, nokuziphatha kwe-gelation.
2. Ukubaluleka Kokufakwa Kwamanzi:
Ukufakwa kwamanzi kubalulekile ukuze uvule ukusebenza kwe-HPMC.Uma i-HPMC ifakwe amanzi, imunca amanzi futhi ivuvuke, okuholela ekwakhekeni kwesixazululo se-viscous noma ijeli, kuye ngokugxila kanye nezimo.Lesi simo esinamanzi senza i-HPMC yenze imisebenzi ehlosiwe, njengokujiya, ukugawula, ukwenza ifilimu, kanye nokugcina ukukhululwa kwezidakamizwa.
3. Izindlela zokufaka amanzi:
Kunezindlela ezimbalwa zokufaka amanzi ku-HPMC, kuya ngesicelo kanye nomphumela oyifunayo:
a.Ukuhlakazwa Kwamanzi Abandayo:
Le ndlela ihlanganisa ukusabalalisa impushana ye-HPMC emanzini abandayo ngenkathi inyakaza kancane.
Ukuhlakazwa kwamanzi abandayo kuyakhethwa ukuvimbela ukunqwabelana nokuqinisekisa ukugeleza kwamanzi okufanayo.
Ngemuva kokuhlakazeka, ikhambi livame ukuvunyelwa ukuthi liqhubekele phambili ngaphansi kokuyaluza okuthambile ukuze kuzuzwe i-viscosity oyifunayo.
b.Ukusabalalisa Amanzi Ashisayo:
Ngale ndlela, i-HPMC powder ihlakazeka emanzini ashisayo, ngokuvamile emazingeni okushisa angaphezu kuka-80°C.
Amanzi ashisayo asiza ukugeleza kwamanzi ngokushesha kanye nokuqedwa kwe-HPMC, okuholela esixazululweni esicacile.
Kufanele kuqashelwe ukugwema ukushisa ngokweqile, okungehlisa isithunzi se-HPMC noma kubangele ukwakheka kwesigaxa.
c.Ukungathathi hlangothi:
Ezinye izinhlelo zokusebenza zingabandakanya ukwenza izixazululo ze-HPMC zibe mnene ngama-alkaline ejenti njenge-sodium hydroxide noma i-potassium hydroxide.
I-Neutralization ilungisa i-pH yesisombululo, engathonya i-viscosity kanye nezakhiwo ze-gelation ze-HPMC.
d.I-Solvent Exchange:
I-HPMC ingaphinda ifakwe amanzi ngokushintshanisa i-solvent, lapho ihlakazwa ku-solvent exubana namanzi njenge-ethanol noma i-methanol bese ishintshaniswa namanzi.
Ukushintshaniswa kwe-solvent kungaba wusizo ezinhlelweni ezidinga ukulawula okunembile phezu kwe-hydration kanye ne-viscosity.
e.I-Pre-Hydration:
I-pre-hydration ihlanganisa ukucwilisa i-HPMC emanzini noma ku-solvent ngaphambi kokuyihlanganisa ekwakhekeni.
Le ndlela iqinisekisa i-hydration ephelele futhi ingaba nenzuzo ekuzuzeni imiphumela engaguquki, ikakhulukazi ekwakhiweni okuyinkimbinkimbi.
4. Izinto Ezithinta Ukufakwa Kwamanzi:
Kunezici eziningana ezithonya ukugeleza kwamanzi kwe-HPMC:
a.Usayizi Wezinhlayiya: I-HPMC powder egayiwe kahle i-hydrates kalula kunezinhlayiya eziqinile ngenxa yokwanda kwendawo.
b.Izinga lokushisa: Amazinga okushisa aphakeme ngokuvamile asheshisa ukugeleza kwamanzi kodwa futhi angathinta i-viscosity nokuziphatha kwe-gelation kwe-HPMC.
c.I-pH: I-pH ye-hydration medium ingathinta isimo se-ionization se-HPMC futhi ngenxa yalokho i-hydration kinetics yayo kanye nezakhiwo ze-rheological.
d.Ukuxuba: Ukuxubana okufanele noma ukuyaluza kubalulekile ekufakweni kwamanzi okufanayo kanye nokuhlakazwa kwezinhlayiya ze-HPMC ku-solvent.
e.Ukugxila: Ukugxila kwe-HPMC ku-hydration medium kuthonya i-viscosity, amandla ejeli, nezinye izici zesixazululo noma ijeli.
5. Izicelo:
I-Hydrated HPMC ithola izinhlelo zokusebenza ezihlukene kuzo zonke izimboni ezahlukene:
a.Ukwakhiwa Kwemithi: Ezingxenyeni zethebulethi, omatikuletsheni abakhishwa okulawulwayo, izixazululo ze-ophthalmic, kanye nokulengiswa.
b.Imikhiqizo Yokudla: Njenge-thickener, stabilizer, noma i-ejenti eyenza ifilimu kumasoso, okokugqoka, imikhiqizo yobisi, kanye ne-confectionery.
c.Izimonyo: Kokhilimu, ama-lotions, ama-gel, nokunye ukwakhiwa kokuguqulwa kwe-viscosity kanye ne-emulsification.
d.Izinto Zokwakha: Emikhiqizweni esekwe usimende, izinto zokunamathisela zamathayela, nama-renders ukuthuthukisa ukusebenza, ukugcinwa kwamanzi, nokunamathela.
6. Ukulawula Ikhwalithi:
Ukufakwa kwamanzi okusebenzayo kwe-HPMC kubalulekile ekusebenzeni komkhiqizo nokuvumelana.Izinyathelo zokulawula ikhwalithi zingabandakanya:
a.Ukuhlaziya Usayizi Wezinhlayiyana: Ukuqinisekisa ukufana kokusabalalisa usayizi wezinhlayiyana ukuze kuthuthukiswe i-hydration kinetics.
b.I-Viscosity Measurement: Ukuqapha i-viscosity ngesikhathi se-hydration ukuze kuzuzwe ukungaguquguquki okufunayo kwesicelo esihlosiwe.
c.I-pH Monitoring: Ukulawula i-pH ye-hydration medium ukuze kuthuthukiswe ukugeleza kwamanzi nokuvimbela ukuwohloka.
d.Ukuhlolwa Okuncane: Ukuhlolwa okubonakalayo kwamasampula anamanzi ngaphansi kwesibonakhulu ukuze kuhlolwe ukuhlakazeka kwezinhlayiyana nobuqotho.
7. Isiphetho:
Ukufakwa kwamanzi kuyinqubo eyisisekelo ekusebenziseni izakhiwo ze-HPMC ezinhlelweni ezihlukahlukene.Ukuqonda izindlela, izici, kanye nezilinganiso zokulawula ikhwalithi ezihambisana nokugeleza kwamanzi kubalulekile ukuze kuthuthukiswe ukusebenza komkhiqizo nokuqinisekisa ukuvumelana ekuhlanganiseni.Ngokufunda kahle ukugeleza kwamanzi kwe-HPMC, abacwaningi nabaqulunqi bangavula amandla ayo aphelele ezimbonini eziningi ezihlukahlukene, beqhuba ukusungula izinto ezintsha nokuthuthukiswa komkhiqizo.
Isikhathi sokuthumela: Mar-04-2024