IHydroxypropylmethylcellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa kabanzi ezimbonini ezahlukahlukene ngenxa yezakhiwo zayo ezihlukile.Le nhlanganisela iphuma ku-cellulose, i-polymer yemvelo etholakala ezindongeni zamaseli ezitshalo.Ukuhlanganiswa kwe-HPMC kuhilela ukwelapha i-cellulose nge-propylene oxide ukwethula amaqembu e-hydroxypropyl kanye ne-methyl chloride ukwethula amaqembu e-methyl.I-polymer ewumphumela ibonisa izinhlobonhlobo zezakhiwo zomzimba namakhemikhali, okwenza ifanelekele ukusetshenziswa embonini yezemithi, yokwakha, yokudla nezinye.
1.Isakhiwo samakhemikhali kanye nokwakheka:
IHydroxypropyl methylcellulose i-semi-synthetic polymer enesakhiwo samakhemikhali esiyinkimbinkimbi.Umgogodla we-polymer uqukethe i-cellulose, iketango lomugqa lama-molecule e-glucose axhunywe ngamabhondi e-β-1,4-glycosidic.Iqembu le-hydroxypropyl lethulwa ngokufaka iqembu le-hydroxyl (-OH) esikhundleni seqembu le-propyl, futhi iqembu le-methyl lethulwa ngendlela efanayo.I-degree of substitution (DS) imele inombolo emaphakathi ye-hydroxypropyl namaqembu e-methyl ngeyunithi ngayinye ye-glucose futhi ithinta ukunyibilika, i-viscosity, kanye nezakhiwo ezishisayo ze-polymer.
2. Ukunyibilika:
Esinye sezici ezihlukile ze-HPMC ukuziphatha kwayo kokuqedwa.Incibilika emanzini abandayo nashisayo, ihlinzeka ngezinzuzo eziyingqayizivele ezinhlobonhlobo zezicelo.I-Solubility ingalungiswa ngokulungisa izinga lokushintshwa kanye nesisindo samangqamuzana we-polymer.Lesi sakhiwo senza i-HPMC ibe yikhandidethi elihle kakhulu lezinhlelo ezilawulwayo zokulethwa kwezidakamizwa, lapho izinga lokuqedwa lidlala indima ebalulekile kukhinekhi yokukhishwa kwezidakamizwa.
3. I-Viscosity:
I-Hydroxypropyl methylcellulose itholakala emazingeni ahlukahlukene e-viscosity, kuye ngezici ezifana nesisindo samangqamuzana, izinga lokushintshwa, kanye nokugxila kwesixazululo.I-viscosity yezixazululo ze-HPMC izivumela ukuthi zisetshenziswe ezinhlelweni eziningi zezimboni, okuhlanganisa nemithi, njengama-thickeners kumafomu omthamo owuketshezi, nanjengezinto zokwakha ifilimu zokumboza.
4. Ukusebenza kokwenza ifilimu:
Ikhono lokwenza ifilimu le-HPMC libalulekile ekusetshenzisweni okufana nokumbozwa kwezidakamizwa, lapho lisetshenziselwa ukunikeza isendlalelo esivikelayo ukuze kufihlwe ukunambitheka kwezidakamizwa, ukulawula ukukhululwa kwezidakamizwa, nokuthuthukisa ukuzinza.Amafilimu e-HPMC acacile futhi avumelana nezimo, futhi izakhiwo zawo zingenziwa ngendlela efanele ngokulungisa ukugxila kwe-polymer, isisindo samangqamuzana nokuqukethwe kwe-plasticizer.
5. Ukusebenza okushisayo:
IHydroxypropyl methylcellulose ibonisa ukuzinza okuhle kokushisa ngaphakathi kwebanga elithile lokushisa.Izakhiwo ezishisayo zithintwa yizici ezifana nezinga lokushintsha, isisindo samangqamuzana, kanye nokuba khona kwamapulasitiki.Lezi zakhiwo zenza i-HPMC ifanelekele izinhlelo zokusebenza lapho ukuqina kwe-thermal kubaluleke kakhulu, njengokulungiswa kokwenziwa kwemithi engezwani nokushisa.
6. I-Biocompatibility:
Emkhakheni wezokwelapha kanye ne-biomedical, i-biocompatibility iwukucatshangelwa okubalulekile kwezinto ezisetshenziswa ezinhlelweni zokulethwa kwezidakamizwa.IHydroxypropyl methylcellulose ngokuvamile ibhekwa njengephephile futhi inokuhambisana okuhle kwe-biocompatibility.Isetshenziswa kakhulu ekwakhiweni kwamafomu omthamo womlomo, izixazululo ze-ophthalmic kanye nezinhlelo zokulethwa kwezidakamizwa ezilawulwayo.
7. Ukugcina amanzi nokujiya:
Amandla e-HPMC okugcina amanzi kanye nezisombululo ezijiyile awenza abe wusizo ezintweni zokwakha njengemikhiqizo esekwe usimende.Kulezi zinhlelo zokusebenza, i-HPMC isebenza njenge-ejenti egcina amanzi, ithuthukisa ukucutshungulwa futhi ivimbele ukomiswa kwempahla ngaphambi kwesikhathi.Izakhiwo ezijiyayo nazo zisetshenziswa emikhiqizweni ehlukahlukene yokudla ukuze kuthuthukiswe ukuthungwa nokuzwakala komlomo.
8. Ukulethwa kwezidakamizwa ezikhishwe okulawulwayo:
Esinye sezicelo ezibalulekile ze-hydroxypropyl methylcellulose kusekwakheni amasistimu okulethwa kwezidakamizwa akhishwe okulawulwayo.Ukuncibilika kwe-polymer, i-viscosity, kanye nezakhiwo zefilimu kusiza ukukhishwa okulawulwayo kwezidakamizwa, okuvumela ukulethwa kwezidakamizwa okuqhubekayo nokuhlosiwe.Lokhu kunenzuzo ikakhulukazi ekuthuthukiseni ukuthobela kwesiguli kanye nokunciphisa imiphumela engemihle ehambisana nokukhululwa kwezidakamizwa ngokushesha.
9. Ukuzinza ngaphansi kwezindawo ezihlukene ze-pH:
I-HPMC ibonisa ukuzinza phezu kwebanga elibanzi le-pH, iyenze ifanele ukwakheka okudinga ukuzinza ngaphansi kwezimo ezine-asidi noma ezine-alkali.Lesi sakhiwo sinenzuzo kwezemithi ngoba ukwakheka kwezidakamizwa kungase kuhlangabezane nezimo ezihlukile ze-pH emgudwini wamathumbu.
10. Izici ze-Rheological:
Ukuziphatha kwe-rheological kwezixazululo ze-HPMC kubalulekile ekusebenzeni lapho izakhiwo zokugeleza zibaluleke kakhulu, njengalapho kulungiswa izinto zokumboza, izinto zokunamathisela namajeli.Izakhiwo ze-rheological zingalungiswa ngokulungisa ukugxila kanye nesisindo samangqamuzana e-HPMC ukuze kuzuzwe izici zokugeleza ezidingekayo ekulawuleni i-e okunembile.
IHydroxypropyl methylcellulose isiphenduke i-polymer ebaluleke kakhulu ezimbonini ezahlukahlukene ngenxa yenhlanganisela yayo eyingqayizivele yokuncibilika, i-viscosity, ikhono lokwenza ifilimu kanye nokuvumelana kwezinto eziphilayo.Ukuguquguquka kwayo kuyenza ifanelekele ukusetshenziswa okunhlobonhlobo, kusukela kwezemithi kanye nezinto zokwakha kuya ekudleni nezimonyo.Njengoba abacwaningi beqhubeka nokuhlola ukwakheka nezinhlelo zokusebenza ezintsha, izakhiwo ze-hydroxypropyl methylcellulose ngokungangabazeki zizofaka isandla ekuthuthukisweni kwemikhakha ehlukahlukene, iqinisekise ukubaluleka kwayo okuqhubekayo kwisayensi yezinto zokwakha kanye nezimboni.
Isikhathi sokuthumela: Jan-10-2024