IHydroxypropyl methylcellulose HPMC wuhlobo lwe-non-ionic cellulose exubile ether.Ngokungafani ne-ionic methyl carboxymethyl cellulose ether exubile, ayisebenzi ngezinsimbi ezisindayo.Ngenxa yezilinganiso ezihlukene zokuqukethwe kwe-methoxyl nokuqukethwe kwe-hydroxypropyl ku-hydroxypropyl methylcellulose kanye nama-viscosities ahlukene, kunezinhlobonhlobo eziningi ezinezakhiwo ezihlukene, isibonelo, okuqukethwe okuphezulu kwe-methoxyl nokuqukethwe kwe-hydroxypropyl ephansi Ukusebenza kwayo kuseduze nalokho kwe-methyl cellulose, kuyilapho lokho okuphansi. okuqukethwe kwe-methoxyl nokuqukethwe okuphezulu kwe-hydroxypropyl kusondele kulokho kwe-hydroxypropyl methyl cellulose.Kodwa-ke, ezinhlobonhlobo ngayinye, nakuba inani elincane kuphela leqembu le-hydroxypropyl noma inani elincane leqembu le-methoxyl liqukethwe, kunomehluko omkhulu ekuncibilikeni kwezinyibilikisi zemvelo noma izinga lokushisa le-flocculation ezixazululweni ezinamanzi.
(1) Izici zokuncibilika kwe-hydroxypropyl methylcellulose
①Ukunyibilika kwe-hydroxypropyl methylcellulose emanzini I-Hydroxypropyl methylcellulose empeleni iwuhlobo lwe-methylcellulose elungiswe yi-propylene oxide (methoxypropylene), ngakho-ke isenezinto ezifanayo ne-methyl cellulose Cellulose inezici ezifanayo zokuncibilika kwamanzi abandayo nokungancibiliki kwamanzi ashisayo.Nokho, ngenxa yeqembu le-hydroxypropyl eliguquliwe, izinga lokushisa layo le-gelation emanzini ashisayo liphakeme kakhulu kunalelo le-methyl cellulose.Isibonelo, i-viscosity yesisombululo samanzi se-hydroxypropyl methylcellulose ene-2% methoxy content substitution degree DS=0.73 kanye ne-hydroxypropyl content MS=0.46 yi-500 mpa·s ku-20°C, kanye nezinga lokushisa lejeli layo Ingafinyelela eduze kuka-100°C, kuyilapho. I-methyl cellulose ezingeni lokushisa elifanayo icishe ibe ngu-55°C.Ngokuqondene nokuncibilika kwayo emanzini, nayo ithuthukiswe kakhulu.Isibonelo, i-hydroxypropyl methylcellulose egayiwe (i-granular shape 0.2~0.5mm ku-20°C ene-aqueous viscosity engu-4% ye-aqueous viscosity engu-2pa•s ingathengwa Ezingeni lokushisa legumbi, inyibilika kalula emanzini ngaphandle kokupholisa.
②Ukunyibilika kwe-hydroxypropyl methylcellulose kuzincibilikisi zemvelo Ukuncibilika kwe-hydroxypropyl methylcellulose kuzinyibilikisi zemvelo nakho kungcono kunaleyo ye-methylcellulose.Emikhiqizweni engaphezulu kuka-2.1, i-high-viscosity hydroxypropyl methylcellulose equkethe i-hydroxypropyl MS=1.5~1.8 kanye ne-methoxy DS=0.2~1.0, enenani eliphelele lokushintshwa elingaphezu kuka-1.8, inyibilika ku-anhydrous methanol ne-ethanol solution Medium, kanye ne-water-soluble .Iphinde inyibilike kuma-hydrocarbons ane-chlorine njenge-methylene chloride ne-chloroform, nezinyibilikisi eziphilayo njenge-acetone, isopropanol ne-diacetone alcohol.Ukuncibilika kwayo ezincibilikisini eziphilayo kungcono kunokuncibilika emanzini.
(2) Izinto ezithinta i-viscosity ye-hydroxypropyl methylcellulose Ukunqunywa kwe-viscosity okujwayelekile kwe-hydroxypropyl methylcellulose kuyafana namanye ama-cellulose ether, futhi kukalwa ku-20°C ngesisombululo samanzi esingu-2% njengesijwayelekile.I-viscosity yomkhiqizo ofanayo iyanda ngokukhula kokugxila.Ngemikhiqizo enesisindo samangqamuzana ahlukene ekugxilweni okufanayo, umkhiqizo onesisindo esikhulu samangqamuzana une-viscosity ephakeme.Ubudlelwano bayo nezinga lokushisa bufana nobe-methyl cellulose.Lapho izinga lokushisa likhuphuka, i-viscosity iqala ukwehla, kodwa lapho ifinyelela izinga lokushisa elithile,
i-viscosity iphakama ngokuzumayo futhi kwenzeka i-gelation.Izinga lokushisa lejeli lemikhiqizo ye-viscosity ephansi liphezulu.iphezulu.Iphuzu layo lejeli alihlobene kuphela ne-viscosity ye-ether, kodwa futhi lihlobene nesilinganiso sokubunjwa kweqembu le-methoxyl neqembu le-hydroxypropyl ku-ether kanye nobukhulu bezinga eliphelele lokushintsha.Kumele kuqashelwe ukuthi i-hydroxypropyl methylcellulose nayo iyi-pseudoplastic, futhi isisombululo sayo sizinzile ekamelweni lokushisa ngaphandle kokuwohloka kwe-viscosity ngaphandle kokuthi kungenzeka ukuwohloka kwe-enzymatic.
(3) Ukubekezelelana kukasawoti we-hydroxypropyl methylcellulose Njengoba i-hydroxypropyl methylcellulose iyi-ether engeyona i-ionic, ayifaki ioni kumithombo yamanzi, ngokungafani namanye ama-ether e-ionic cellulose, Ngokwesibonelo, i-carboxymethyl cellulose isabela nama-ion ensimbi esindayo futhi idonse esixazululweni.Usawoti ojwayelekile njenge-chloride, i-bromide, i-phosphate, i-nitrate, njll. ngeke zehle uma zengezwe kusixazululo sawo esinamanzi.Nokho, ukwengeza usawoti kunethonya elithile ekushiseni kwe-flocculation yesixazululo saso esinamanzi.Lapho ukuhlushwa kukasawoti kukhuphuka, izinga lokushisa lejeli liyancipha.Lapho ukuhlushwa kukasawoti kungaphansi kwendawo ye-flocculation, i-viscosity yesisombululo ivame ukwanda.Ngakho-ke, inani elithile likasawoti liyengezwa., ekusetshenzisweni, ingafinyelela umphumela wokuqina ngokwezomnotho.Ngakho-ke, kwezinye izinhlelo zokusebenza, kungcono ukusebenzisa ingxube ye-cellulose ether nosawoti kunokugxila okuphezulu kwesisombululo se-ether ukuze kuzuzwe umphumela wokuqina.
(4) I-Hydroxypropyl methylcellulose acid kanye nokumelana ne-alkali I-Hydroxypropyl methylcellulose ngokuvamile izinzile kuma-acids nama-alkali, futhi ayithinteki ebangeni le-pH 2~12.Ingakwazi ukumelana nenani elithile lama-acids akhanyayo, njenge-formic acid, i-acetic acid, i-citric acid, i-succinic acid, i-phosphoric acid, i-boric acid, njll. Kodwa i-asidi egxilile inomphumela wokunciphisa i-viscosity.Ama-alkali afana ne-caustic soda, i-caustic potash kanye namanzi e-lime awanawo umthelela kuwo, kodwa angakhuphula kancane i-viscosity yesisombululo, bese enciphisa kancane kancane.
(5) Ukungezwani kwe-hydroxypropyl methylcellulose Isixazululo se-Hydroxypropyl methylcellulose singaxutshwa nezinhlanganisela ze-polymer ezincibilika emanzini ukuze zibe isixazululo esifana nesesisobala esine-viscosity ephezulu.Lezi zinhlanganisela ze-polymer zihlanganisa i-polyethylene glycol, i-polyvinyl acetate, i-polysilicone, i-polymethylvinylsiloxane, i-hydroxyethyl cellulose, ne-methyl cellulose.Izinhlanganisela zemvelo zamangqamuzana aphezulu njenge-gum arabic, i-cust bean gum, i-karaya gum, njll. nazo zinokuhambisana okuhle nesixazululo sayo.IHydroxypropyl methylcellulose ingabuye ixutshwe ne-mannitol ester noma i-sorbitol ester ye-stearic acid noma i-palmitic acid, futhi ingaxutshwa ne-glycerin, i-sorbitol ne-mannitol, futhi lezi zinhlanganisela zingasetshenziswa njenge-hydroxypropyl methylcellulose Plasticizer ye-cellulose.
(6) Ama-ether e-cellulose e-cellulose angancibiliki emanzini e-hydroxypropyl methylcellulose angaxhunyaniswa nama-aldehyde phezulu, ukuze lawa ma-ether ancibilikayo ancibilike esixazululweni futhi angancibiliki emanzini.I-aldehyde eyenza i-hydroxypropyl methylcellulose ingancibiliki ihlanganisa i-formaldehyde, i-glyoxal, i-succinic aldehyde, i-adipaldehyde, njll. i-ejenti ekukhiqizeni izimboni.Inani lalolu hlobo lwe-ejenti yokuxhumanisa esixazululweni ngu-0.2% ~ 10% wesisindo se-ether, okungcono kakhulu u-7% ~ 10%, isibonelo, u-3.3% ~ 6% we-glyoxal iyona efaneleka kakhulu.Ngokuvamile, ukwelashwa
izinga lokushisa ngu-0 ~ 30 ℃, futhi isikhathi ngu-1 ~ 120min.Ukusabela kwe-cross-linking kufanele kwenziwe ngaphansi kwezimo ze-acidic.Ngokuvamile, isixazululo siqala sengezwe nge-asidi eqinile ye-inorganic noma i-organic carboxylic acid ukuze kulungiswe i-pH yesisombululo ibe cishe ku-2~6, okungcono kakhulu phakathi kuka-4 ~ 6, bese wengeza ama-aldehyde ukuze kwenziwe ukusabela okuxhumanisa .I-asidi esetshenzisiwe ine-hydrochloric acid, i-sulfuric acid, i-phosphoric acid, i-formic acid, i-acetic acid, i-hydroxyacetic acid, i-succinic acid noma i-citric acid njll., lapho nge-formic acid noma i-acetic acid inconywa, futhi i-formic acid ilungile.I-asidi ne-aldehyde nazo zingangezwa ngesikhathi esisodwa ukuvumela isisombululo ukuthi sibhekane nokusabela okuxhumanisa phakathi kwebanga le-pH elifunekayo.Lokhu kusabela kuvame ukusetshenziswa enqubweni yokugcina yokwelapha ohlelweni lokulungiselela ama-cellulose ethers.Ngemuva kokuthi i-cellulose ether ingancibiliki, kulula ukuyisebenzisa
20 ~ 25℃ amanzi okugeza nokuhlanza.Lapho umkhiqizo usetshenziswa, izinto ezine-alkali zingafakwa esixazululweni somkhiqizo ukuze kulungiswe i-pH yesisombululo ukuze ibe yi-alkaline, futhi umkhiqizo uzoncibilika esixazululweni ngokushesha.Le ndlela iphinde isebenze ekwelapheni ifilimu ngemuva kokuthi isisombululo se-cellulose ether senziwe ifilimu ukuze senze ifilimu engancibiliki.
(7)Ukungazweli kwe-enzyme ye-hydroxypropyl methylcellulose ngokusobala kuwukuphuma kwe-cellulose, njengeqembu ngalinye le-anhydroglucose, uma kuneqembu elibambele elibophene ngokuqinile, akulula ukungenwa ama-microorganisms, kodwa empeleni umkhiqizo oqediwe Lapho inani elishintshayo lidlula. 1, izophinde yonakaliswe ngama-enzyme, okusho ukuthi izinga lokushintsha kweqembu ngalinye ochungechungeni lwe-cellulose alifani ngokwanele, futhi ama-microorganisms angaguguleka eqenjini le-anhydroglucose elingashintshiwe ukuze enze ushukela, njengezakhi zofuzo ukuze ama-microorganisms amunce.Ngakho-ke, uma izinga lokushintshwa kwe-etherification ye-cellulose likhuphuka, ukumelana nokuguguleka kwe-enzymatic ye-cellulose ether nakho kuzokhula.Ngokwemibiko, ngaphansi kwezimo ezilawulwayo, imiphumela ye-hydrolysis yama-enzyme, i-viscosity esele ye-hydroxypropyl methylcellulose (DS=1.9) ingu-13.2%, i-methylcellulose (DS=1.83) ingu-7.3%, i-methylcellulose (DS=1.66) ingu-3.8%, futhi i-hydroxyethyl cellulose ingu-1.7%.Kungabonakala ukuthi i-hydroxypropyl methylcellulose inekhono eliqinile lokulwa nama-enzyme.Ngakho-ke, ukumelana okuhle kakhulu kwe-enzyme ye-hydroxypropyl methylcellulose, kuhlangene nokuhlakazeka kwayo okuhle, ukuqina kanye nezakhiwo zefilimu, kusetshenziselwa ukumboza kwamanzi emulsion, njll, futhi ngokuvamile akudingi ukwengeza ama-preservatives.Kodwa-ke, ukuze kugcinwe isikhathi eside isisombululo noma ukungcoliswa okungenzeka okuvela ngaphandle, ama-preservatives angangezwa njengendlela yokuqapha, futhi ukukhetha kunganqunywa ngokuvumelana nezidingo zokugcina zesisombululo.I-Phenylmercuric acetate kanye ne-manganese fluorosilicate yizilondolozi ezisebenzayo, kodwa zonke zinobuthi, kufanele kuqashelwe ukusebenza.Ngokuvamile, i-1 ~ 5mg ye-phenylmercury acetate ingangezwa kwisixazululo ilitha ngalinye lomthamo.
(8) Ukusebenza kwefilimu ye-hydroxypropyl methylcellulose I-Hydroxypropyl methylcellulose inezici ezinhle kakhulu zokwenza ifilimu.Isixazululo saso esinamanzi noma i-organic solvent solution simbozwa epuleti lengilazi, futhi singabi nambala futhi sibe sobala ngemva kokumiswa.Futhi ifilimu enzima.Inokumelana okuhle nomswakama futhi ihlala iqinile emazingeni okushisa aphezulu.Uma i-plasticizer ye-hygroscopic yengezwa, ubude bayo kanye nokuguquguquka kwayo kungathuthukiswa.Mayelana nokuthuthukisa ukuguquguquka, ama-plasticizers afana ne-glycerin ne-sorbitol yiwona afaneleka kakhulu.Ngokuvamile, ukugxilwa kwesixazululo ngu-2% ~ 3%, kanti inani le-plasticizer liyi-10% ~ 20% ye-cellulose ether.Uma okuqukethwe kwe-plasticizer kuphezulu kakhulu, i-colloidal dehydration shrinkage izokwenzeka kumswakama ophezulu.Amandla aqinile wefilimu nge
i-plasticizer eyengeziwe inkulu kakhulu kunalokho ngaphandle kwe-plasticizer, futhi iyanda ngokunyuka kwenani elingeziwe.Ngokuqondene ne-hygroscopicity yefilimu, iphinde ikhule ngokunyuka kwenani le-plasticizer.
Isikhathi sokuthumela: Nov-24-2022