IHydroxypropyl methylcellulose (HPMC) iyi-polymer eguquguqukayo esetshenziswa kabanzi ezimbonini ezahlukahlukene ngenxa yezakhiwo zayo ezihlukile.Njengento ephuma ku-cellulose, i-HPMC ithathwe ku-cellulose yemvelo futhi inamaqembu e-hydroxypropyl nama-methyl anamathiselwe kumgogodla we-cellulose.Lokhu kuguqulwa kunikeza i-HPMC izakhiwo ezifiselekayo, okuyenza ifanelekele ukusetshenziswa okuhlukahlukene, okuhlanganisa imithi, ukwakhiwa, ukudla, nemikhiqizo yokunakekela komuntu siqu.
Ukukhetha ibanga elilungile le-HPMC kubalulekile ukuze kuzuzwe ukusebenza okudingekayo kuhlelo lokusebenza oluthile.Izinto ezimbalwa zithonya ukukhethwa kwe-HPMC, okuhlanganisa i-viscosity, i-methoxy ne-hydroxypropyl okuqukethwe, uhlobo lokufaka esikhundleni, nosayizi wezinhlayiyana.Kule ngxoxo, sizobhekisisa lezi zici futhi sihlole ukuthi zikuthinta kanjani ukukhethwa kwe-HPMC kwezinhlelo zokusebenza ezahlukene.
1. I-Viscosity:
Enye yezinto ezibalulekile lapho ukhetha i-HPMC yi-viscosity yayo.I-viscosity ibhekisela ekuphikisweni koketshezi ukugeleza.Ku-HPMC, i-viscosity isilinganiso sogqinsi noma ukungaguquguquki kwesixazululo.Hlukanaizinhlelo zokusebenza zidinga amamaki e-viscosity ahlukene e-HPMC.Ngokwesibonelo:
Ezemithi: Ekwenziweni kwemithi, i-HPMC ivamise ukusetshenziswa njenge-ejenti yokuqina kanye ne-gelling.Ukukhethwa kwebanga le-viscosity kuncike ekuthunjweni okufiswayo komkhiqizo wokugcina, kungaba amaphilisi, amaphilisi noma ukwakheka okuwuketshezi.
Ukwakhiwa: Embonini yezokwakha, i-HPMC isetshenziswa kabanzi odakeni lwengxube eyomile.I-viscosity ye-HPMC ithinta ukugcinwa kwamanzi, ukusebenza kanye nokumelana nokucwila kodaka.Izinhlelo zokusebenza eziqondile ngokuvamile zikhetha amamaki aphezulu e-viscosity ukuvimbela ukuhlehla.
2. Okuqukethwe kwe-Methoxy ne-hydroxypropyl:
Izinga lokushintsha (DS) le-HPMC lisho izinga lokushintshanisa i-hydroxypropyl namaqembu e-methoxy ochungechungeni oluyinhloko lwe-cellulose futhi kuyisici esibalulekile.Amanani ahlukene e-DS angaholela ku-to izinguquko ku-solubility, gelation, nezinye izakhiwo.Okucatshangelwayo kuhlanganisa:
Ukumbozwa kwefilimu emithini yemithi: I-HPMC enokuqukethwe kwe-methoxyl ephansi ivamise ukuncamela ukumbozwa kwefilimu emithini yemithi ngoba ithuthukisa izakhiwo zokwenza ifilimu futhi inciphise izinzwa.itivity ezimweni zemvelo.
3. Olunye uhlobo:
Uhlobo lokushintsha kungenye into ebalulekile.I-HPMC ingancibilika ngokushesha (ebuye ibizwe ngokuthi “i-hydration esheshayo”) noma incibilike kancane.Inketho incike kuphrofayela yokukhishwa edingekayo kuhlelo lokusebenza lwekhemisi.Ngokwesibonelo:
Ukwakhiwa kokukhishwa okulawulwayo: Ekwakhekeni kokukhishwa okulawulwayo, amamaki ancibilika kancane e-HPMC angase anconywe ukuze kuzuzwe ukukhululwa okuqhubekayo kwe-ingre yezemithi esebenzayo.i-dient.
4. Usayizi we-particle:
Usayizi wezinhlayiya uthinta ukuhlakazeka nokuncibilika kwe-HPMC esixazululweni.Izinhlayiya ezinhle zivame ukuncibilika kalula, okuthinta ukusebenza okuphelele ezinhlelweni ezahlukahlukene:
Imboni Yokudla: Embonini yokudla, i-HPMC isetshenziswa ezinhlelweni ezinjengokuqina nokuqiniswa.Okusanhlamvu okuhleI-ed HPMC ivamise ukuthandwa ngenxa yezakhiwo zayo zokusheshisa nokuhlakazeka ekwakhiweni kokudla.
5. Ukuhambisana nezinye izithako:
Ukuhambisana kwe-HPMC nezinye izithako ekwakhiweni kubalulekile ekusebenzeni kwayo kukonke.Lokhu kubandakanya ukuhambisana nezithako zemithi ezisebenzayo (ama-API) emithini noma ukuhambisana nezinye izithasiselo ezintweni zokwakha.
Imikhiqizo Yezidakamizwa: I-HPMC kufanele bihambisana ne-API ukuze kuqinisekiswe ukuzinza nokusabalalisa okufanayo ngaphakathi kwefomu lomthamo.
6. Ukuthobela Umthetho:
Ekusetshenzisweni kwemithi nokudla, ukuthobela imithetho kubalulekile.Ibanga le-HPMC elikhethiwe kufanele lihambisane ne-pharmacopoeia efanele noma amazinga okungeza ukudla.
Izidakamizwa nokudla: Ukuhambisana nezindinganiso eziyisinxephezelo (isb, i-USP, EP, JP) noma umthethonqubo wokungeza ukudlans (isb, imithetho ye-FDA) ibalulekile ukuze kuqinisekiswe ukuphepha nokusebenza ngempumelelo.
7. Ukucatshangelwa kwezindleko:
Izindleko ziwukucatshangelwa okungokoqobo kunoma yisiphi isicelo sezimboni.Lapho ukhetha ibanga elilungile le-HPMC, ukulinganisa izidingo zokusebenza nokucatshangelwa kwezindleko kubalulekile.
Imboni Yezokwakha: Embonini yezokwakha, i-HPMC isetshenziswa kakhulu ekuhlanganiseni okomile, lapho ukuphumelela kwezindleko kuwukucatshangelwa okubalulekile.
Ukukhethwa okufanele kwe-hydroxypropyl methylcellulose kudinga ukucatshangelwa ngokucophelela kwezici ezihlukahlukene, kuhlanganise ne-viscosity, i-methoxy ne-hydroxypropyl okuqukethwe, uhlobo lokufaka esikhundleni, usayizi wezinhlayiyana, ukuhambisana nezinye izithako, ukuhambisana nokulawula kanye nezindleko.Uhlelo ngalunye lunezidingo ezithile, futhi ukukhetha ibanga elilungile le-HPMC kuqinisekisa ukusebenza okuphelele nezici ezifiselekayo zomkhiqizo wokugcina.Kunconywa ukusebenza nabahlinzeki nabakhiqizi abangahlinzeka ngosekelo lobuchwepheshe nesiqondiso ukuze bakusize ukhethe ibanga le-HPMC elifaneleka kakhulu kuhlelo lwakho lokusebenza oluthile.
Isikhathi sokuthumela: Jan-02-2024